Abnormal transcranial Döppler ultrasonography in children with sickle cell disease

Detalhes bibliográficos
Autor(a) principal: Leite, Ana Claudia Celestino Bezerra
Data de Publicação: 2012
Outros Autores: Oliveira, Raquel Vasconcellos Carvalhaes de, Moura, Patrícia Gomes de, Silva, Célia Maria, Lobo, Clarisse
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36732
Resumo: Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Leite, Ana Claudia Celestino BezerraOliveira, Raquel Vasconcellos Carvalhaes deMoura, Patrícia Gomes deSilva, Célia MariaLobo, Clarisse2019-10-29T13:04:49Z2019-10-29T13:04:49Z2012LEITE, Ana Claudia Celestino Bezerra et al. Abnormal transcranial Döppler ultrasonography in children with sickle cell disease. Revista Brasileira de Hematologia e Hemoterapia, v. 34, n. 4, p. 307-310, 2012.1516-8484https://www.arca.fiocruz.br/handle/icict/3673210.5581/1516-8484.201200781806-0870engElsevierAbnormal transcranial Döppler ultrasonography in children with sickle cell diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil.Fundação Centro de Hematologia e Hemoterapia de Minas Gerais. Belo Horizonte, MG, Brasil.Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Background: Stroke is a potentially fatal complication of sickle cell disease in children between 2-16 years and transcranial Döppler has been recommended as a screening method in these cases. Objective: The main goal of this study was to correlate transcranial Döppler results to complications related to stroke in sickle cell disease and baseline characteristics of the population. Methods: This was an observational study of children and adolescents with ages between 2-16 years with sickle cell disease who were followed in three centers. Results: From January 2008 to July 2009, 902 patients were enrolled in this study. The median age was 6.5 years (range: 1.8-15.8), 52.3% were male, 74.4% had hemoglobin SS; 221 (28.6%) had at least one complication associated with sickle cell disease. A total of 773 patients performed transcranial Döppler; in 91.2% this was a method of screening. Conditional or abnormal transcranial Döppler results were more common in patients with sickle cell disease complications versus those without complications (ODDS ratio = 3.18; 95% Confidence interval = 1.92-5.27). There was a significant difference in the frequency of conditional or abnormal transcranial Döppler results in patients with abnormal laboratory results compared to those without abnormalities (OR=4.03); 95% confidence interval = 2.30-7.06. Conclusions: Conditional or abnormal transcranial Döppler results were significantly more frequent in patients with complications of sickle cell disease confirming the increased risk of stroke in this subgroup of patients. This observation reinforces the recommendation of transcranial Döppler as a screening test for all patients with sickle cell disease with ages between 2 and 16 years.UltrasonographyTranscranial DöpplerSickle cell anemiaStrokeCerebrovascular circulationChildinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36732/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Leite_Ana_etal_INI_2012.pdfve_Leite_Ana_etal_INI_2012.pdfEmbargo vencidoapplication/pdf235930https://www.arca.fiocruz.br/bitstream/icict/36732/2/ve_Leite_Ana_etal_INI_2012.pdf66c5db289f2916c25779ff668c77f45cMD52TEXTve_Leite_Ana_etal_INI_2012.pdf.txtve_Leite_Ana_etal_INI_2012.pdf.txtExtracted texttext/plain21160https://www.arca.fiocruz.br/bitstream/icict/36732/3/ve_Leite_Ana_etal_INI_2012.pdf.txtba0900d58aac4ca75dcd0bf0e111a8c9MD53icict/367322021-06-18 09:02:57.462oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-06-18T12:02:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Abnormal transcranial Döppler ultrasonography in children with sickle cell disease
title Abnormal transcranial Döppler ultrasonography in children with sickle cell disease
spellingShingle Abnormal transcranial Döppler ultrasonography in children with sickle cell disease
Leite, Ana Claudia Celestino Bezerra
Ultrasonography
Transcranial Döppler
Sickle cell anemia
Stroke
Cerebrovascular circulation
Child
title_short Abnormal transcranial Döppler ultrasonography in children with sickle cell disease
title_full Abnormal transcranial Döppler ultrasonography in children with sickle cell disease
title_fullStr Abnormal transcranial Döppler ultrasonography in children with sickle cell disease
title_full_unstemmed Abnormal transcranial Döppler ultrasonography in children with sickle cell disease
title_sort Abnormal transcranial Döppler ultrasonography in children with sickle cell disease
author Leite, Ana Claudia Celestino Bezerra
author_facet Leite, Ana Claudia Celestino Bezerra
Oliveira, Raquel Vasconcellos Carvalhaes de
Moura, Patrícia Gomes de
Silva, Célia Maria
Lobo, Clarisse
author_role author
author2 Oliveira, Raquel Vasconcellos Carvalhaes de
Moura, Patrícia Gomes de
Silva, Célia Maria
Lobo, Clarisse
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Leite, Ana Claudia Celestino Bezerra
Oliveira, Raquel Vasconcellos Carvalhaes de
Moura, Patrícia Gomes de
Silva, Célia Maria
Lobo, Clarisse
dc.subject.en.pt_BR.fl_str_mv Ultrasonography
Transcranial Döppler
Sickle cell anemia
Stroke
Cerebrovascular circulation
Child
topic Ultrasonography
Transcranial Döppler
Sickle cell anemia
Stroke
Cerebrovascular circulation
Child
description Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-10-29T13:04:49Z
dc.date.available.fl_str_mv 2019-10-29T13:04:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LEITE, Ana Claudia Celestino Bezerra et al. Abnormal transcranial Döppler ultrasonography in children with sickle cell disease. Revista Brasileira de Hematologia e Hemoterapia, v. 34, n. 4, p. 307-310, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36732
dc.identifier.issn.pt_BR.fl_str_mv 1516-8484
dc.identifier.doi.none.fl_str_mv 10.5581/1516-8484.20120078
dc.identifier.eissn.none.fl_str_mv 1806-0870
identifier_str_mv LEITE, Ana Claudia Celestino Bezerra et al. Abnormal transcranial Döppler ultrasonography in children with sickle cell disease. Revista Brasileira de Hematologia e Hemoterapia, v. 34, n. 4, p. 307-310, 2012.
1516-8484
10.5581/1516-8484.20120078
1806-0870
url https://www.arca.fiocruz.br/handle/icict/36732
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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