Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Daniela Laranja Gomes [UNIFESP]
Data de Publicação: 2017
Outros Autores: Adegoke, Samuel Ademola [UNIFESP], Campos, Rejane de Souza Macedo [UNIFESP], Braga, Josefina Aparecida Pellegrini [UNIFESP], Figueiredo, Maria Stella [UNIFESP], Silva, Gisele Sampaio [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/0004-282X20160175
https://repositorio.unifesp.br/handle/11600/56458
Resumo: Transcranial doppler (TCD) is a strategic component of primary stroke prevention in children with sickle cell disease (SCD). This study was conducted to examine the TCD characteristics of children with SCD in nine different medical centers in Brazil. Methods: Transcranial doppler was performed in accordance with the Stroke Prevention Trial in Sickle Cell Anemia Protocol. Results: Of the 396 patients, 69.5% had homozygous SS hemoglobin. The TCD result was abnormal in 4.8%, conditional in 12.6%, inadequate in 4.3% and abnormally low in 1% of patients. The highest mean flow velocities were 121 +/- 23.83cm/s and 124 +/- 27.21cm/s in the left and right middle cerebral artery respectively. A total of 28.8% patients (mean age 9.19 +/- 5.92 years) were evaluated with TCD for the first time. Conclusions: The SCD patients were evaluated with TCD at an older age, representing an important missed opportunity for stroke prevention. Since TCD screening in patients with SCD is important to detect those at high risk for stroke, it is recommended that this screening should be made more readily available.
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spelling Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidencesickle cell diseaseultrasonographydopplertranscranialstrokeTranscranial doppler (TCD) is a strategic component of primary stroke prevention in children with sickle cell disease (SCD). This study was conducted to examine the TCD characteristics of children with SCD in nine different medical centers in Brazil. Methods: Transcranial doppler was performed in accordance with the Stroke Prevention Trial in Sickle Cell Anemia Protocol. Results: Of the 396 patients, 69.5% had homozygous SS hemoglobin. The TCD result was abnormal in 4.8%, conditional in 12.6%, inadequate in 4.3% and abnormally low in 1% of patients. The highest mean flow velocities were 121 +/- 23.83cm/s and 124 +/- 27.21cm/s in the left and right middle cerebral artery respectively. A total of 28.8% patients (mean age 9.19 +/- 5.92 years) were evaluated with TCD for the first time. Conclusions: The SCD patients were evaluated with TCD at an older age, representing an important missed opportunity for stroke prevention. Since TCD screening in patients with SCD is important to detect those at high risk for stroke, it is recommended that this screening should be made more readily available.Univ Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo, SP, BrazilObafemi Awolowo Univ, Dept Pediat & Child Hlth, Ife, NigeriaUniv Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, BrazilHosp Israelita Albert Einstein, Programa Integrado Neurol, Sao Paulo, SP, BrazilUniversidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, BrasilUniversidade Federal de São Paulo, Departamento de Oncologia Clínica e Experimental, São Paulo SP, BrasilUniversidade Federal de São Paulo, Departamento de Pediatria, São Paulo SP, BrasilWeb of ScienceAssoc Arquivos Neuro- Psiquiatria2020-07-31T12:46:55Z2020-07-31T12:46:55Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15-19application/pdfhttp://dx.doi.org/10.1590/0004-282X20160175Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 1, p. 15-19, 2017.10.1590/0004-282X20160175S0004-282X2017000100015.pdf0004-282XS0004-282X2017000100015https://repositorio.unifesp.br/handle/11600/56458WOS:000393268400004engArquivos De Neuro-PsiquiatriaSao Paulo Spinfo:eu-repo/semantics/openAccessRodrigues, Daniela Laranja Gomes [UNIFESP]Adegoke, Samuel Ademola [UNIFESP]Campos, Rejane de Souza Macedo [UNIFESP]Braga, Josefina Aparecida Pellegrini [UNIFESP]Figueiredo, Maria Stella [UNIFESP]Silva, Gisele Sampaio [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-11T11:24:40Zoai:repositorio.unifesp.br/:11600/56458Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-11T11:24:40Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence
title Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence
spellingShingle Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence
Rodrigues, Daniela Laranja Gomes [UNIFESP]
sickle cell disease
ultrasonography
doppler
transcranial
stroke
title_short Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence
title_full Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence
title_fullStr Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence
title_full_unstemmed Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence
title_sort Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence
author Rodrigues, Daniela Laranja Gomes [UNIFESP]
author_facet Rodrigues, Daniela Laranja Gomes [UNIFESP]
Adegoke, Samuel Ademola [UNIFESP]
Campos, Rejane de Souza Macedo [UNIFESP]
Braga, Josefina Aparecida Pellegrini [UNIFESP]
Figueiredo, Maria Stella [UNIFESP]
Silva, Gisele Sampaio [UNIFESP]
author_role author
author2 Adegoke, Samuel Ademola [UNIFESP]
Campos, Rejane de Souza Macedo [UNIFESP]
Braga, Josefina Aparecida Pellegrini [UNIFESP]
Figueiredo, Maria Stella [UNIFESP]
Silva, Gisele Sampaio [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Daniela Laranja Gomes [UNIFESP]
Adegoke, Samuel Ademola [UNIFESP]
Campos, Rejane de Souza Macedo [UNIFESP]
Braga, Josefina Aparecida Pellegrini [UNIFESP]
Figueiredo, Maria Stella [UNIFESP]
Silva, Gisele Sampaio [UNIFESP]
dc.subject.por.fl_str_mv sickle cell disease
ultrasonography
doppler
transcranial
stroke
topic sickle cell disease
ultrasonography
doppler
transcranial
stroke
description Transcranial doppler (TCD) is a strategic component of primary stroke prevention in children with sickle cell disease (SCD). This study was conducted to examine the TCD characteristics of children with SCD in nine different medical centers in Brazil. Methods: Transcranial doppler was performed in accordance with the Stroke Prevention Trial in Sickle Cell Anemia Protocol. Results: Of the 396 patients, 69.5% had homozygous SS hemoglobin. The TCD result was abnormal in 4.8%, conditional in 12.6%, inadequate in 4.3% and abnormally low in 1% of patients. The highest mean flow velocities were 121 +/- 23.83cm/s and 124 +/- 27.21cm/s in the left and right middle cerebral artery respectively. A total of 28.8% patients (mean age 9.19 +/- 5.92 years) were evaluated with TCD for the first time. Conclusions: The SCD patients were evaluated with TCD at an older age, representing an important missed opportunity for stroke prevention. Since TCD screening in patients with SCD is important to detect those at high risk for stroke, it is recommended that this screening should be made more readily available.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-07-31T12:46:55Z
2020-07-31T12:46:55Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/0004-282X20160175
Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 1, p. 15-19, 2017.
10.1590/0004-282X20160175
S0004-282X2017000100015.pdf
0004-282X
S0004-282X2017000100015
https://repositorio.unifesp.br/handle/11600/56458
WOS:000393268400004
url http://dx.doi.org/10.1590/0004-282X20160175
https://repositorio.unifesp.br/handle/11600/56458
identifier_str_mv Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 1, p. 15-19, 2017.
10.1590/0004-282X20160175
S0004-282X2017000100015.pdf
0004-282X
S0004-282X2017000100015
WOS:000393268400004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos De Neuro-Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15-19
application/pdf
dc.coverage.none.fl_str_mv Sao Paulo Sp
dc.publisher.none.fl_str_mv Assoc Arquivos Neuro- Psiquiatria
publisher.none.fl_str_mv Assoc Arquivos Neuro- Psiquiatria
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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