Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/0004-282X20160175 https://repositorio.unifesp.br/handle/11600/56458 |
Resumo: | Transcranial doppler (TCD) is a strategic component of primary stroke prevention in children with sickle cell disease (SCD). This study was conducted to examine the TCD characteristics of children with SCD in nine different medical centers in Brazil. Methods: Transcranial doppler was performed in accordance with the Stroke Prevention Trial in Sickle Cell Anemia Protocol. Results: Of the 396 patients, 69.5% had homozygous SS hemoglobin. The TCD result was abnormal in 4.8%, conditional in 12.6%, inadequate in 4.3% and abnormally low in 1% of patients. The highest mean flow velocities were 121 +/- 23.83cm/s and 124 +/- 27.21cm/s in the left and right middle cerebral artery respectively. A total of 28.8% patients (mean age 9.19 +/- 5.92 years) were evaluated with TCD for the first time. Conclusions: The SCD patients were evaluated with TCD at an older age, representing an important missed opportunity for stroke prevention. Since TCD screening in patients with SCD is important to detect those at high risk for stroke, it is recommended that this screening should be made more readily available. |
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Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidencesickle cell diseaseultrasonographydopplertranscranialstrokeTranscranial doppler (TCD) is a strategic component of primary stroke prevention in children with sickle cell disease (SCD). This study was conducted to examine the TCD characteristics of children with SCD in nine different medical centers in Brazil. Methods: Transcranial doppler was performed in accordance with the Stroke Prevention Trial in Sickle Cell Anemia Protocol. Results: Of the 396 patients, 69.5% had homozygous SS hemoglobin. The TCD result was abnormal in 4.8%, conditional in 12.6%, inadequate in 4.3% and abnormally low in 1% of patients. The highest mean flow velocities were 121 +/- 23.83cm/s and 124 +/- 27.21cm/s in the left and right middle cerebral artery respectively. A total of 28.8% patients (mean age 9.19 +/- 5.92 years) were evaluated with TCD for the first time. Conclusions: The SCD patients were evaluated with TCD at an older age, representing an important missed opportunity for stroke prevention. Since TCD screening in patients with SCD is important to detect those at high risk for stroke, it is recommended that this screening should be made more readily available.Univ Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo, SP, BrazilObafemi Awolowo Univ, Dept Pediat & Child Hlth, Ife, NigeriaUniv Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, BrazilHosp Israelita Albert Einstein, Programa Integrado Neurol, Sao Paulo, SP, BrazilUniversidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, BrasilUniversidade Federal de São Paulo, Departamento de Oncologia Clínica e Experimental, São Paulo SP, BrasilUniversidade Federal de São Paulo, Departamento de Pediatria, São Paulo SP, BrasilWeb of ScienceAssoc Arquivos Neuro- Psiquiatria2020-07-31T12:46:55Z2020-07-31T12:46:55Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15-19application/pdfhttp://dx.doi.org/10.1590/0004-282X20160175Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 1, p. 15-19, 2017.10.1590/0004-282X20160175S0004-282X2017000100015.pdf0004-282XS0004-282X2017000100015https://repositorio.unifesp.br/handle/11600/56458WOS:000393268400004engArquivos De Neuro-PsiquiatriaSao Paulo Spinfo:eu-repo/semantics/openAccessRodrigues, Daniela Laranja Gomes [UNIFESP]Adegoke, Samuel Ademola [UNIFESP]Campos, Rejane de Souza Macedo [UNIFESP]Braga, Josefina Aparecida Pellegrini [UNIFESP]Figueiredo, Maria Stella [UNIFESP]Silva, Gisele Sampaio [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-11T11:24:40Zoai:repositorio.unifesp.br/:11600/56458Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-11T11:24:40Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence |
title |
Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence |
spellingShingle |
Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence Rodrigues, Daniela Laranja Gomes [UNIFESP] sickle cell disease ultrasonography doppler transcranial stroke |
title_short |
Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence |
title_full |
Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence |
title_fullStr |
Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence |
title_full_unstemmed |
Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence |
title_sort |
Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence |
author |
Rodrigues, Daniela Laranja Gomes [UNIFESP] |
author_facet |
Rodrigues, Daniela Laranja Gomes [UNIFESP] Adegoke, Samuel Ademola [UNIFESP] Campos, Rejane de Souza Macedo [UNIFESP] Braga, Josefina Aparecida Pellegrini [UNIFESP] Figueiredo, Maria Stella [UNIFESP] Silva, Gisele Sampaio [UNIFESP] |
author_role |
author |
author2 |
Adegoke, Samuel Ademola [UNIFESP] Campos, Rejane de Souza Macedo [UNIFESP] Braga, Josefina Aparecida Pellegrini [UNIFESP] Figueiredo, Maria Stella [UNIFESP] Silva, Gisele Sampaio [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, Daniela Laranja Gomes [UNIFESP] Adegoke, Samuel Ademola [UNIFESP] Campos, Rejane de Souza Macedo [UNIFESP] Braga, Josefina Aparecida Pellegrini [UNIFESP] Figueiredo, Maria Stella [UNIFESP] Silva, Gisele Sampaio [UNIFESP] |
dc.subject.por.fl_str_mv |
sickle cell disease ultrasonography doppler transcranial stroke |
topic |
sickle cell disease ultrasonography doppler transcranial stroke |
description |
Transcranial doppler (TCD) is a strategic component of primary stroke prevention in children with sickle cell disease (SCD). This study was conducted to examine the TCD characteristics of children with SCD in nine different medical centers in Brazil. Methods: Transcranial doppler was performed in accordance with the Stroke Prevention Trial in Sickle Cell Anemia Protocol. Results: Of the 396 patients, 69.5% had homozygous SS hemoglobin. The TCD result was abnormal in 4.8%, conditional in 12.6%, inadequate in 4.3% and abnormally low in 1% of patients. The highest mean flow velocities were 121 +/- 23.83cm/s and 124 +/- 27.21cm/s in the left and right middle cerebral artery respectively. A total of 28.8% patients (mean age 9.19 +/- 5.92 years) were evaluated with TCD for the first time. Conclusions: The SCD patients were evaluated with TCD at an older age, representing an important missed opportunity for stroke prevention. Since TCD screening in patients with SCD is important to detect those at high risk for stroke, it is recommended that this screening should be made more readily available. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2020-07-31T12:46:55Z 2020-07-31T12:46:55Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0004-282X20160175 Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 1, p. 15-19, 2017. 10.1590/0004-282X20160175 S0004-282X2017000100015.pdf 0004-282X S0004-282X2017000100015 https://repositorio.unifesp.br/handle/11600/56458 WOS:000393268400004 |
url |
http://dx.doi.org/10.1590/0004-282X20160175 https://repositorio.unifesp.br/handle/11600/56458 |
identifier_str_mv |
Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 1, p. 15-19, 2017. 10.1590/0004-282X20160175 S0004-282X2017000100015.pdf 0004-282X S0004-282X2017000100015 WOS:000393268400004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos De Neuro-Psiquiatria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
15-19 application/pdf |
dc.coverage.none.fl_str_mv |
Sao Paulo Sp |
dc.publisher.none.fl_str_mv |
Assoc Arquivos Neuro- Psiquiatria |
publisher.none.fl_str_mv |
Assoc Arquivos Neuro- Psiquiatria |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268387608494080 |