Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings

Detalhes bibliográficos
Autor(a) principal: Silva, Gisele Sampaio [UNIFESP]
Data de Publicação: 2009
Outros Autores: Vicari, Perla [UNIFESP], Figueiredo, Maria Stella [UNIFESP], Carrete Junior, Henrique [UNIFESP], Idagawa, Marcos Hideki [UNIFESP], Massaro, Ayrton Roberto [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1161/STROKEAHA.108.537415
http://repositorio.unifesp.br/handle/11600/31620
Resumo: Background and Purpose-Brain imaging abnormalities were reported in up to 44% of children with sickle cell disease (SCD). the prevalence of neuroimaging abnormalities in adult patients with SCD and their relationship to transcranial Doppler is still unclear. Our objectives were to study the frequency of MRI and MR angiography abnormalities in adults with SCD and to define what transcranial Doppler velocities are associated with intracranial stenoses detected by MR angiography.Methods-We examined all adult patients (>16 years) with SCD followed in the hematology outpatient clinic at our university hospital with MRI, MR angiography, and transcranial Doppler.Results-We evaluated 50 patients. the overall prevalence of MRI abnormalities was 60%. Abnormal MRI findings were more frequent when vessel tortuosity or stenoses were present on MR angiography (P<0.01). Patients with intracranial stenoses had significantly higher time-averaged maximum mean velocities (P=0.01). A time-averaged maximum mean velocity of 123.5 cm/s allowed the diagnosis of middle cerebral artery or internal carotid artery intracranial stenosis with sensitivity of 100% and specificity of 73% with an area under the receiver operator characteristic curve of 0.91 (CI, 0.79 to 1.00).Conclusions-The frequency of brain imaging abnormalities detected by MRI/MR angiography in adults with SCD was higher than that described for children. Transcranial Doppler velocities in adult patients with intracranial stenoses were lower than those described for the pediatric population with SCD. (Stroke. 2009; 40: 2408-2412.)
id UFSP_90aa1682927bfcad0533f01614df5d39
oai_identifier_str oai:repositorio.unifesp.br/:11600/31620
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findingsmagnetic resonance imagingsickle cell anemiastroketranscranial Doppler ultrasonographyBackground and Purpose-Brain imaging abnormalities were reported in up to 44% of children with sickle cell disease (SCD). the prevalence of neuroimaging abnormalities in adult patients with SCD and their relationship to transcranial Doppler is still unclear. Our objectives were to study the frequency of MRI and MR angiography abnormalities in adults with SCD and to define what transcranial Doppler velocities are associated with intracranial stenoses detected by MR angiography.Methods-We examined all adult patients (>16 years) with SCD followed in the hematology outpatient clinic at our university hospital with MRI, MR angiography, and transcranial Doppler.Results-We evaluated 50 patients. the overall prevalence of MRI abnormalities was 60%. Abnormal MRI findings were more frequent when vessel tortuosity or stenoses were present on MR angiography (P<0.01). Patients with intracranial stenoses had significantly higher time-averaged maximum mean velocities (P=0.01). A time-averaged maximum mean velocity of 123.5 cm/s allowed the diagnosis of middle cerebral artery or internal carotid artery intracranial stenosis with sensitivity of 100% and specificity of 73% with an area under the receiver operator characteristic curve of 0.91 (CI, 0.79 to 1.00).Conclusions-The frequency of brain imaging abnormalities detected by MRI/MR angiography in adults with SCD was higher than that described for children. Transcranial Doppler velocities in adult patients with intracranial stenoses were lower than those described for the pediatric population with SCD. (Stroke. 2009; 40: 2408-2412.)Universidade Federal de São Paulo, Dept Neurol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Hematol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Radiol, São Paulo, BrazilCtr Diagnost Fleury, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Hematol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Radiol, São Paulo, BrazilWeb of ScienceLippincott Williams & WilkinsUniversidade Federal de São Paulo (UNIFESP)Ctr Diagnost FleurySilva, Gisele Sampaio [UNIFESP]Vicari, Perla [UNIFESP]Figueiredo, Maria Stella [UNIFESP]Carrete Junior, Henrique [UNIFESP]Idagawa, Marcos Hideki [UNIFESP]Massaro, Ayrton Roberto [UNIFESP]2016-01-24T13:52:39Z2016-01-24T13:52:39Z2009-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2408-2412http://dx.doi.org/10.1161/STROKEAHA.108.537415Stroke. Philadelphia: Lippincott Williams & Wilkins, v. 40, n. 7, p. 2408-2412, 2009.10.1161/STROKEAHA.108.5374150039-2499http://repositorio.unifesp.br/handle/11600/31620WOS:000267467900021engStrokeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2016-01-24T11:52:39Zoai:repositorio.unifesp.br/:11600/31620Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T11:52:39Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings
title Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings
spellingShingle Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings
Silva, Gisele Sampaio [UNIFESP]
magnetic resonance imaging
sickle cell anemia
stroke
transcranial Doppler ultrasonography
title_short Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings
title_full Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings
title_fullStr Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings
title_full_unstemmed Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings
title_sort Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings
author Silva, Gisele Sampaio [UNIFESP]
author_facet Silva, Gisele Sampaio [UNIFESP]
Vicari, Perla [UNIFESP]
Figueiredo, Maria Stella [UNIFESP]
Carrete Junior, Henrique [UNIFESP]
Idagawa, Marcos Hideki [UNIFESP]
Massaro, Ayrton Roberto [UNIFESP]
author_role author
author2 Vicari, Perla [UNIFESP]
Figueiredo, Maria Stella [UNIFESP]
Carrete Junior, Henrique [UNIFESP]
Idagawa, Marcos Hideki [UNIFESP]
Massaro, Ayrton Roberto [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Ctr Diagnost Fleury
dc.contributor.author.fl_str_mv Silva, Gisele Sampaio [UNIFESP]
Vicari, Perla [UNIFESP]
Figueiredo, Maria Stella [UNIFESP]
Carrete Junior, Henrique [UNIFESP]
Idagawa, Marcos Hideki [UNIFESP]
Massaro, Ayrton Roberto [UNIFESP]
dc.subject.por.fl_str_mv magnetic resonance imaging
sickle cell anemia
stroke
transcranial Doppler ultrasonography
topic magnetic resonance imaging
sickle cell anemia
stroke
transcranial Doppler ultrasonography
description Background and Purpose-Brain imaging abnormalities were reported in up to 44% of children with sickle cell disease (SCD). the prevalence of neuroimaging abnormalities in adult patients with SCD and their relationship to transcranial Doppler is still unclear. Our objectives were to study the frequency of MRI and MR angiography abnormalities in adults with SCD and to define what transcranial Doppler velocities are associated with intracranial stenoses detected by MR angiography.Methods-We examined all adult patients (>16 years) with SCD followed in the hematology outpatient clinic at our university hospital with MRI, MR angiography, and transcranial Doppler.Results-We evaluated 50 patients. the overall prevalence of MRI abnormalities was 60%. Abnormal MRI findings were more frequent when vessel tortuosity or stenoses were present on MR angiography (P<0.01). Patients with intracranial stenoses had significantly higher time-averaged maximum mean velocities (P=0.01). A time-averaged maximum mean velocity of 123.5 cm/s allowed the diagnosis of middle cerebral artery or internal carotid artery intracranial stenosis with sensitivity of 100% and specificity of 73% with an area under the receiver operator characteristic curve of 0.91 (CI, 0.79 to 1.00).Conclusions-The frequency of brain imaging abnormalities detected by MRI/MR angiography in adults with SCD was higher than that described for children. Transcranial Doppler velocities in adult patients with intracranial stenoses were lower than those described for the pediatric population with SCD. (Stroke. 2009; 40: 2408-2412.)
publishDate 2009
dc.date.none.fl_str_mv 2009-07-01
2016-01-24T13:52:39Z
2016-01-24T13:52:39Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1161/STROKEAHA.108.537415
Stroke. Philadelphia: Lippincott Williams & Wilkins, v. 40, n. 7, p. 2408-2412, 2009.
10.1161/STROKEAHA.108.537415
0039-2499
http://repositorio.unifesp.br/handle/11600/31620
WOS:000267467900021
url http://dx.doi.org/10.1161/STROKEAHA.108.537415
http://repositorio.unifesp.br/handle/11600/31620
identifier_str_mv Stroke. Philadelphia: Lippincott Williams & Wilkins, v. 40, n. 7, p. 2408-2412, 2009.
10.1161/STROKEAHA.108.537415
0039-2499
WOS:000267467900021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Stroke
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2408-2412
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268388759830528