Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1161/STROKEAHA.108.537415 http://repositorio.unifesp.br/handle/11600/31620 |
Resumo: | Background and Purpose-Brain imaging abnormalities were reported in up to 44% of children with sickle cell disease (SCD). the prevalence of neuroimaging abnormalities in adult patients with SCD and their relationship to transcranial Doppler is still unclear. Our objectives were to study the frequency of MRI and MR angiography abnormalities in adults with SCD and to define what transcranial Doppler velocities are associated with intracranial stenoses detected by MR angiography.Methods-We examined all adult patients (>16 years) with SCD followed in the hematology outpatient clinic at our university hospital with MRI, MR angiography, and transcranial Doppler.Results-We evaluated 50 patients. the overall prevalence of MRI abnormalities was 60%. Abnormal MRI findings were more frequent when vessel tortuosity or stenoses were present on MR angiography (P<0.01). Patients with intracranial stenoses had significantly higher time-averaged maximum mean velocities (P=0.01). A time-averaged maximum mean velocity of 123.5 cm/s allowed the diagnosis of middle cerebral artery or internal carotid artery intracranial stenosis with sensitivity of 100% and specificity of 73% with an area under the receiver operator characteristic curve of 0.91 (CI, 0.79 to 1.00).Conclusions-The frequency of brain imaging abnormalities detected by MRI/MR angiography in adults with SCD was higher than that described for children. Transcranial Doppler velocities in adult patients with intracranial stenoses were lower than those described for the pediatric population with SCD. (Stroke. 2009; 40: 2408-2412.) |
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Repositório Institucional da UNIFESP |
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Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findingsmagnetic resonance imagingsickle cell anemiastroketranscranial Doppler ultrasonographyBackground and Purpose-Brain imaging abnormalities were reported in up to 44% of children with sickle cell disease (SCD). the prevalence of neuroimaging abnormalities in adult patients with SCD and their relationship to transcranial Doppler is still unclear. Our objectives were to study the frequency of MRI and MR angiography abnormalities in adults with SCD and to define what transcranial Doppler velocities are associated with intracranial stenoses detected by MR angiography.Methods-We examined all adult patients (>16 years) with SCD followed in the hematology outpatient clinic at our university hospital with MRI, MR angiography, and transcranial Doppler.Results-We evaluated 50 patients. the overall prevalence of MRI abnormalities was 60%. Abnormal MRI findings were more frequent when vessel tortuosity or stenoses were present on MR angiography (P<0.01). Patients with intracranial stenoses had significantly higher time-averaged maximum mean velocities (P=0.01). A time-averaged maximum mean velocity of 123.5 cm/s allowed the diagnosis of middle cerebral artery or internal carotid artery intracranial stenosis with sensitivity of 100% and specificity of 73% with an area under the receiver operator characteristic curve of 0.91 (CI, 0.79 to 1.00).Conclusions-The frequency of brain imaging abnormalities detected by MRI/MR angiography in adults with SCD was higher than that described for children. Transcranial Doppler velocities in adult patients with intracranial stenoses were lower than those described for the pediatric population with SCD. (Stroke. 2009; 40: 2408-2412.)Universidade Federal de São Paulo, Dept Neurol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Hematol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Radiol, São Paulo, BrazilCtr Diagnost Fleury, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Hematol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Radiol, São Paulo, BrazilWeb of ScienceLippincott Williams & WilkinsUniversidade Federal de São Paulo (UNIFESP)Ctr Diagnost FleurySilva, Gisele Sampaio [UNIFESP]Vicari, Perla [UNIFESP]Figueiredo, Maria Stella [UNIFESP]Carrete Junior, Henrique [UNIFESP]Idagawa, Marcos Hideki [UNIFESP]Massaro, Ayrton Roberto [UNIFESP]2016-01-24T13:52:39Z2016-01-24T13:52:39Z2009-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2408-2412http://dx.doi.org/10.1161/STROKEAHA.108.537415Stroke. Philadelphia: Lippincott Williams & Wilkins, v. 40, n. 7, p. 2408-2412, 2009.10.1161/STROKEAHA.108.5374150039-2499http://repositorio.unifesp.br/handle/11600/31620WOS:000267467900021engStrokeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2016-01-24T11:52:39Zoai:repositorio.unifesp.br/:11600/31620Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T11:52:39Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings |
title |
Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings |
spellingShingle |
Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings Silva, Gisele Sampaio [UNIFESP] magnetic resonance imaging sickle cell anemia stroke transcranial Doppler ultrasonography |
title_short |
Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings |
title_full |
Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings |
title_fullStr |
Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings |
title_full_unstemmed |
Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings |
title_sort |
Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease Correlation With Transcranial Doppler Findings |
author |
Silva, Gisele Sampaio [UNIFESP] |
author_facet |
Silva, Gisele Sampaio [UNIFESP] Vicari, Perla [UNIFESP] Figueiredo, Maria Stella [UNIFESP] Carrete Junior, Henrique [UNIFESP] Idagawa, Marcos Hideki [UNIFESP] Massaro, Ayrton Roberto [UNIFESP] |
author_role |
author |
author2 |
Vicari, Perla [UNIFESP] Figueiredo, Maria Stella [UNIFESP] Carrete Junior, Henrique [UNIFESP] Idagawa, Marcos Hideki [UNIFESP] Massaro, Ayrton Roberto [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Ctr Diagnost Fleury |
dc.contributor.author.fl_str_mv |
Silva, Gisele Sampaio [UNIFESP] Vicari, Perla [UNIFESP] Figueiredo, Maria Stella [UNIFESP] Carrete Junior, Henrique [UNIFESP] Idagawa, Marcos Hideki [UNIFESP] Massaro, Ayrton Roberto [UNIFESP] |
dc.subject.por.fl_str_mv |
magnetic resonance imaging sickle cell anemia stroke transcranial Doppler ultrasonography |
topic |
magnetic resonance imaging sickle cell anemia stroke transcranial Doppler ultrasonography |
description |
Background and Purpose-Brain imaging abnormalities were reported in up to 44% of children with sickle cell disease (SCD). the prevalence of neuroimaging abnormalities in adult patients with SCD and their relationship to transcranial Doppler is still unclear. Our objectives were to study the frequency of MRI and MR angiography abnormalities in adults with SCD and to define what transcranial Doppler velocities are associated with intracranial stenoses detected by MR angiography.Methods-We examined all adult patients (>16 years) with SCD followed in the hematology outpatient clinic at our university hospital with MRI, MR angiography, and transcranial Doppler.Results-We evaluated 50 patients. the overall prevalence of MRI abnormalities was 60%. Abnormal MRI findings were more frequent when vessel tortuosity or stenoses were present on MR angiography (P<0.01). Patients with intracranial stenoses had significantly higher time-averaged maximum mean velocities (P=0.01). A time-averaged maximum mean velocity of 123.5 cm/s allowed the diagnosis of middle cerebral artery or internal carotid artery intracranial stenosis with sensitivity of 100% and specificity of 73% with an area under the receiver operator characteristic curve of 0.91 (CI, 0.79 to 1.00).Conclusions-The frequency of brain imaging abnormalities detected by MRI/MR angiography in adults with SCD was higher than that described for children. Transcranial Doppler velocities in adult patients with intracranial stenoses were lower than those described for the pediatric population with SCD. (Stroke. 2009; 40: 2408-2412.) |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-07-01 2016-01-24T13:52:39Z 2016-01-24T13:52:39Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1161/STROKEAHA.108.537415 Stroke. Philadelphia: Lippincott Williams & Wilkins, v. 40, n. 7, p. 2408-2412, 2009. 10.1161/STROKEAHA.108.537415 0039-2499 http://repositorio.unifesp.br/handle/11600/31620 WOS:000267467900021 |
url |
http://dx.doi.org/10.1161/STROKEAHA.108.537415 http://repositorio.unifesp.br/handle/11600/31620 |
identifier_str_mv |
Stroke. Philadelphia: Lippincott Williams & Wilkins, v. 40, n. 7, p. 2408-2412, 2009. 10.1161/STROKEAHA.108.537415 0039-2499 WOS:000267467900021 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Stroke |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2408-2412 |
dc.publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268388759830528 |