The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18062 |
Resumo: | CAPES-MEC, CNPq, Programa Ciências Sem Fronteiras, CPqGM-FIOCRUZ, and FAPERJ for the financial support. BRA is a Young Talent Fellow from Science Without Frontiers Program, CAPES-MEC (CsF/BJT – 88887.091752/2014-00) |
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Menezes, Juliana Perrone deSaraiva, Elvira MariaAzevedo, Bruno da Rocha2017-03-16T16:57:00Z2017-03-16T16:57:00Z2016MENEZES, J. P.; SARAIVA, E. M.; AZEVEDO, B. R. The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis. Parasites & Vectors, v. 9, p. 264, 2016.1756-3305https://www.arca.fiocruz.br/handle/icict/1806210.1186/s13071-016-1540-3CAPES-MEC, CNPq, Programa Ciências Sem Fronteiras, CPqGM-FIOCRUZ, and FAPERJ for the financial support. BRA is a Young Talent Fellow from Science Without Frontiers Program, CAPES-MEC (CsF/BJT – 88887.091752/2014-00)Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Departamento de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / The University of Texas Southwestern Medical Center. Harry Hines Boulevard. Dallas, TX, USALeishmania spp., the causative agents of leishmaniasis, are intracellular parasites, transmitted to humans via the bite of their sand fly vectors. Once inoculated, the promastigotes are exposed to the dermis, which is composed of extracellular matrix (ECM), growth factors and its resident cells. Promastigote forms are phagocytosed by macrophages recruited to the site of the sand fly bite, either directly or after interaction with neutrophils. Since Leishmania is an intracellular parasite, its interaction with the host ECM has been neglected as well as the immediate steps after the sand fly bite. However, promastigotes must overcome the obstacles presented by the dermis ECM in order to establish the infection. Thus, the study of the interaction between Leishmania promastigotes and ECM components as well as the earliest stages of infection are important steps to understand the establishment of the disease, and could contribute in the future to new drug developments towards leishmaniasis.engBioMed CentralLeishmaniaMatriz extracelularMacrófagosNeutrófilosLeishmaniaExtracellular matrixMacrophagesNeutrophilsThe site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18062/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMenezes JP The site of the bite....pdfMenezes JP The site of the 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dc.title.pt_BR.fl_str_mv |
The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
title |
The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
spellingShingle |
The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis Menezes, Juliana Perrone de Leishmania Matriz extracelular Macrófagos Neutrófilos Leishmania Extracellular matrix Macrophages Neutrophils |
title_short |
The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
title_full |
The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
title_fullStr |
The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
title_full_unstemmed |
The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
title_sort |
The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
author |
Menezes, Juliana Perrone de |
author_facet |
Menezes, Juliana Perrone de Saraiva, Elvira Maria Azevedo, Bruno da Rocha |
author_role |
author |
author2 |
Saraiva, Elvira Maria Azevedo, Bruno da Rocha |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Menezes, Juliana Perrone de Saraiva, Elvira Maria Azevedo, Bruno da Rocha |
dc.subject.other.pt_BR.fl_str_mv |
Leishmania Matriz extracelular Macrófagos Neutrófilos |
topic |
Leishmania Matriz extracelular Macrófagos Neutrófilos Leishmania Extracellular matrix Macrophages Neutrophils |
dc.subject.en.pt_BR.fl_str_mv |
Leishmania Extracellular matrix Macrophages Neutrophils |
description |
CAPES-MEC, CNPq, Programa Ciências Sem Fronteiras, CPqGM-FIOCRUZ, and FAPERJ for the financial support. BRA is a Young Talent Fellow from Science Without Frontiers Program, CAPES-MEC (CsF/BJT – 88887.091752/2014-00) |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-03-16T16:57:00Z |
dc.date.available.fl_str_mv |
2017-03-16T16:57:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MENEZES, J. P.; SARAIVA, E. M.; AZEVEDO, B. R. The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis. Parasites & Vectors, v. 9, p. 264, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/18062 |
dc.identifier.issn.pt_BR.fl_str_mv |
1756-3305 |
dc.identifier.doi.none.fl_str_mv |
10.1186/s13071-016-1540-3 |
identifier_str_mv |
MENEZES, J. P.; SARAIVA, E. M.; AZEVEDO, B. R. The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis. Parasites & Vectors, v. 9, p. 264, 2016. 1756-3305 10.1186/s13071-016-1540-3 |
url |
https://www.arca.fiocruz.br/handle/icict/18062 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
BioMed Central |
publisher.none.fl_str_mv |
BioMed Central |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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