Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7627 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil. |
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Kano, Flora SatikoSanchez, Bruno Antonio MarinhoSousa, Taís Nóbrega deTang, Michaelis LorenSaliba, JéssicaOliveira, Fernando MeirelesNogueira, Paulo AfonsoPorcuna, Alessandra Queiroga Gonçalves PérezFontes, Cor Jesus FernandesSoares, Irene da SilvaBrito, Cristiana Ferreira Alves deRocha, Roberto SenaCarvalho, Luzia Helena de2014-05-15T16:49:42Z2014-05-15T16:49:42Z2012KANO, Flora Satiko et al. Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region. Tropical Medicine and International Health, v. 17, p. 989-1000, 2012.1360-2276https://www.arca.fiocruz.br/handle/icict/762710.1111/j.1365-3156.2012.03016.xengBlackwell Science LtdPlasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Regioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Universidade Federal do Mato Grosso. Cuiabá, MT, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil.Universidade Federal do Mato Grosso. Cuiabá, MT, Brazil.Universidade de São Paulo. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, , Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil.Objective To investigate risk factors associated with the acquisition of antibodies against Plasmodium vivax Duffy binding protein (PvDBP) – a leading malaria vaccine candidate – in a well-consolidated agricultural settlement of the Brazilian Amazon Region and to determine the sequence diversity of the PvDBP ligand domain (DBPII) within the local malaria parasite population. Methods Demographic, epidemiological and clinical data were collected from 541 volunteers using a structured questionnaire. Malaria parasites were detected by conventional microscopy and PCR, and blood collection was used for antibody assays and molecular characterisation of DBPII. Results The frequency of malaria infection was 7% (6% for P. vivax and 1% for P. falciparum), with malaria cases clustered near mosquito breeding sites. Nearly 50% of settlers had anti-PvDBP IgG antibodies, as detected by enzyme-linked immunosorbent assay (ELISA) with subject’s age being the only strong predictor of seropositivity to PvDBP. Unexpectedly, low levels of DBPII diversity were found within the local malaria parasites, suggesting the existence of low gene flow between P. vivax populations, probably due to the relative isolation of the studied settlement. Conclusion The recognition of PvDBP by a significant proportion of the community, associated with low levels of DBPII diversity among local P. vivax, reinforces the variety of malaria transmission patterns in communities from frontier settlements. Such studies should provide baseline information for antimalarial vaccines now in development.Plasmodium vivaxDuffy binding proteinAntibodiesPolymorphismsFrontier settlementinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPlasmodium vivax Duffy binding protein.pdfPlasmodium vivax Duffy binding protein.pdfapplication/pdf2382248https://www.arca.fiocruz.br/bitstream/icict/7627/1/Plasmodium%20vivax%20Duffy%20binding%20protein.pdfbbd32d2a83acd45efbce07144709c865MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7627/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTPlasmodium vivax Duffy binding protein.pdf.txtPlasmodium vivax Duffy binding protein.pdf.txtExtracted texttext/plain12https://www.arca.fiocruz.br/bitstream/icict/7627/5/Plasmodium%20vivax%20Duffy%20binding%20protein.pdf.txt36c6f0b2061da514c400c0bc2749b5cfMD55THUMBNAILPlasmodium vivax Duffy binding protein.pdf.jpgPlasmodium vivax Duffy binding protein.pdf.jpgGenerated Thumbnailimage/jpeg1969https://www.arca.fiocruz.br/bitstream/icict/7627/4/Plasmodium%20vivax%20Duffy%20binding%20protein.pdf.jpge21954df0a77defa0d97d5e96f4cd548MD54icict/76272023-02-02 10:30:21.269oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-02-02T13:30:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region |
| title |
Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region |
| spellingShingle |
Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region Kano, Flora Satiko Plasmodium vivax Duffy binding protein Antibodies Polymorphisms Frontier settlement |
| title_short |
Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region |
| title_full |
Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region |
| title_fullStr |
Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region |
| title_full_unstemmed |
Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region |
| title_sort |
Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region |
| author |
Kano, Flora Satiko |
| author_facet |
Kano, Flora Satiko Sanchez, Bruno Antonio Marinho Sousa, Taís Nóbrega de Tang, Michaelis Loren Saliba, Jéssica Oliveira, Fernando Meireles Nogueira, Paulo Afonso Porcuna, Alessandra Queiroga Gonçalves Pérez Fontes, Cor Jesus Fernandes Soares, Irene da Silva Brito, Cristiana Ferreira Alves de Rocha, Roberto Sena Carvalho, Luzia Helena de |
| author_role |
author |
| author2 |
Sanchez, Bruno Antonio Marinho Sousa, Taís Nóbrega de Tang, Michaelis Loren Saliba, Jéssica Oliveira, Fernando Meireles Nogueira, Paulo Afonso Porcuna, Alessandra Queiroga Gonçalves Pérez Fontes, Cor Jesus Fernandes Soares, Irene da Silva Brito, Cristiana Ferreira Alves de Rocha, Roberto Sena Carvalho, Luzia Helena de |
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author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Kano, Flora Satiko Sanchez, Bruno Antonio Marinho Sousa, Taís Nóbrega de Tang, Michaelis Loren Saliba, Jéssica Oliveira, Fernando Meireles Nogueira, Paulo Afonso Porcuna, Alessandra Queiroga Gonçalves Pérez Fontes, Cor Jesus Fernandes Soares, Irene da Silva Brito, Cristiana Ferreira Alves de Rocha, Roberto Sena Carvalho, Luzia Helena de |
| dc.subject.en.pt_BR.fl_str_mv |
Plasmodium vivax Duffy binding protein Antibodies Polymorphisms Frontier settlement |
| topic |
Plasmodium vivax Duffy binding protein Antibodies Polymorphisms Frontier settlement |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil. |
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2012 |
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2012 |
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2014-05-15T16:49:42Z |
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2014-05-15T16:49:42Z |
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info:eu-repo/semantics/article |
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KANO, Flora Satiko et al. Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region. Tropical Medicine and International Health, v. 17, p. 989-1000, 2012. |
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https://www.arca.fiocruz.br/handle/icict/7627 |
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1360-2276 |
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10.1111/j.1365-3156.2012.03016.x |
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KANO, Flora Satiko et al. Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region. Tropical Medicine and International Health, v. 17, p. 989-1000, 2012. 1360-2276 10.1111/j.1365-3156.2012.03016.x |
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Blackwell Science Ltd |
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Blackwell Science Ltd |
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