The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Sousa,Taís Nóbrega de
Data de Publicação: 2014
Outros Autores: Kano,Flora Satiko, Brito,Cristiana Ferreira Alves de, Carvalho,Luzia Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500608
Resumo: Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania.
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spelling The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian AmazonmalariaPlasmodium vivaxDuffy binding proteinnaturally acquired antibodiesgenetic variabilityPlasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania.Instituto Oswaldo Cruz, Ministério da Saúde2014-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500608Memórias do Instituto Oswaldo Cruz v.109 n.5 2014reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-0276130592info:eu-repo/semantics/openAccessSousa,Taís Nóbrega deKano,Flora SatikoBrito,Cristiana Ferreira Alves deCarvalho,Luzia Helenaeng2020-04-25T17:51:46Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:19:45.01Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
spellingShingle The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
Sousa,Taís Nóbrega de
malaria
Plasmodium vivax
Duffy binding protein
naturally acquired antibodies
genetic variability
title_short The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_full The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_fullStr The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_full_unstemmed The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_sort The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
author Sousa,Taís Nóbrega de
author_facet Sousa,Taís Nóbrega de
Kano,Flora Satiko
Brito,Cristiana Ferreira Alves de
Carvalho,Luzia Helena
author_role author
author2 Kano,Flora Satiko
Brito,Cristiana Ferreira Alves de
Carvalho,Luzia Helena
author2_role author
author
author
dc.contributor.author.fl_str_mv Sousa,Taís Nóbrega de
Kano,Flora Satiko
Brito,Cristiana Ferreira Alves de
Carvalho,Luzia Helena
dc.subject.por.fl_str_mv malaria
Plasmodium vivax
Duffy binding protein
naturally acquired antibodies
genetic variability
topic malaria
Plasmodium vivax
Duffy binding protein
naturally acquired antibodies
genetic variability
dc.description.none.fl_txt_mv Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania.
description Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500608
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500608
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-0276130592
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.109 n.5 2014
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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