Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks

Detalhes bibliográficos
Autor(a) principal: Lima, Lyana Rodrigues
Data de Publicação: 2014
Outros Autores: Almeida, Adilson José de, Tourinho, Renata dos Santos, Hasselmann, Bárbara, Ximenez, Lia Laura Lewis, Paula, Vanessa Salete de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10273
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.
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spelling Lima, Lyana RodriguesAlmeida, Adilson José deTourinho, Renata dos SantosHasselmann, BárbaraXimenez, Lia Laura LewisPaula, Vanessa Salete de2015-05-08T14:08:47Z2015-05-08T14:08:47Z2014LIMA, Lyana Rodrigues et al. Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks. Plos One, v.9, n.7, 6p, 2014.https://www.arca.fiocruz.br/handle/icict/1027310.1371/journal.pone.0102925engPlos OneHepatite AHepatite Viral HumanaHepatitis A VirusPerson-to-Person TransmissionEvidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaksinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório de Hepatites Virais. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée Guinle. Setor de Hematologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.The person-to-person transmission of the hepatitis A virus primarily occurs in enclosed spaces, particularly in the presence of inadequate hygiene conditions and a high proportion of susceptible individuals. Thus, intimate family contact stands out as a risk factor for HAV infection dissemination. The present study aimed to evaluate the occurrence of household HAV transmission. Blood samples were collected from patients with hepatitis A (index cases) and their family members (contacts) that were referred to an ambulatory care clinic specializing in viral hepatitis. A total of 97 samples were collected from 30 families with a confirmed hepatitis A case (index case). Serological and molecular techniques for the diagnosis of hepatitis A were conducted on all samples. HAV infection (anti-HAV IgM + and/or HAV RNA +) was detected in 34.3% (23/67) of the contacts; 34.3% (23/67) of the contacts were immune to HAV, and 31.4% (21/67) were susceptible. In the household contacts, HAV immunity was significantly associated with older age; susceptibility to infection and HAV infection were associated with younger age. Household outbreaks were detected in 16/30 families studied. Co-circulation of subgenotypes IA and IB was found in the household outbreaks, and person-to-person transmission was evidenced in six of the household outbreaks, with 100% homology between the index case and contact strains. The results demonstrated the relevance of HAV household transmission, reaffirming the need for hepatitis A vaccine administration in susceptible contacts and effective infection control procedures to prevent the extension of household outbreaks.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10273/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALlyana_limaetal_IOCF_2014.pdfapplication/pdf258584https://www.arca.fiocruz.br/bitstream/icict/10273/2/lyana_limaetal_IOCF_2014.pdf8921c0e6cc509e5f7067267e25b3043eMD52TEXTlyana_limaetal_IOCF_2014.pdf.txtlyana_limaetal_IOCF_2014.pdf.txtExtracted texttext/plain33186https://www.arca.fiocruz.br/bitstream/icict/10273/3/lyana_limaetal_IOCF_2014.pdf.txt3c18c2f34f00f7e621f15ebdaf852a5cMD53icict/102732022-06-24 12:19:36.458oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:19:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks
title Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks
spellingShingle Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks
Lima, Lyana Rodrigues
Hepatite A
Hepatite Viral Humana
Hepatitis A Virus
Person-to-Person Transmission
title_short Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks
title_full Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks
title_fullStr Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks
title_full_unstemmed Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks
title_sort Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks
author Lima, Lyana Rodrigues
author_facet Lima, Lyana Rodrigues
Almeida, Adilson José de
Tourinho, Renata dos Santos
Hasselmann, Bárbara
Ximenez, Lia Laura Lewis
Paula, Vanessa Salete de
author_role author
author2 Almeida, Adilson José de
Tourinho, Renata dos Santos
Hasselmann, Bárbara
Ximenez, Lia Laura Lewis
Paula, Vanessa Salete de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Lyana Rodrigues
Almeida, Adilson José de
Tourinho, Renata dos Santos
Hasselmann, Bárbara
Ximenez, Lia Laura Lewis
Paula, Vanessa Salete de
dc.subject.other.pt_BR.fl_str_mv Hepatite A
Hepatite Viral Humana
topic Hepatite A
Hepatite Viral Humana
Hepatitis A Virus
Person-to-Person Transmission
dc.subject.en.pt_BR.fl_str_mv Hepatitis A Virus
Person-to-Person Transmission
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-08T14:08:47Z
dc.date.available.fl_str_mv 2015-05-08T14:08:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, Lyana Rodrigues et al. Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks. Plos One, v.9, n.7, 6p, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10273
dc.identifier.doi.pt_BR.fl_str_mv 10.1371/journal.pone.0102925
identifier_str_mv LIMA, Lyana Rodrigues et al. Evidence of Hepatitis A Virus Person-to-Person Transmission in Household Outbreaks. Plos One, v.9, n.7, 6p, 2014.
10.1371/journal.pone.0102925
url https://www.arca.fiocruz.br/handle/icict/10273
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Plos One
publisher.none.fl_str_mv Plos One
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