Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling

Detalhes bibliográficos
Autor(a) principal: Miyazaki, Yasunari
Data de Publicação: 2014
Outros Autores: Abreu, Adriana Vieira de, Harris, Estelle S, Shah, Amrapali M, Weyrich, Andrew S, Faria Neto, Hugo C. Castro, Zimmerman, Guy A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10548
Resumo: Tokyo Medical and Dental University. Department of Respiratory Medicine. Tokio, Japan.
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spelling Miyazaki, YasunariAbreu, Adriana Vieira deHarris, Estelle SShah, Amrapali MWeyrich, Andrew SFaria Neto, Hugo C. CastroZimmerman, Guy A2015-05-27T13:39:51Z2015-05-27T13:39:51Z2014MIYAZAKI, Yasunari et al. Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling. Plos One, v.11, n.9, 25p, 2014.https://www.arca.fiocruz.br/handle/icict/105480.1371/journal.pone.0112770engPlos OneIntegrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signalinginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTokyo Medical and Dental University. Department of Respiratory Medicine. Tokio, Japan.University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Immunofarmacologia. Rio de Janeiro. RJ, Brasil.University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA.University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA.University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA / University of Utah School of Medicine. Program in Molecular Medicine. Salt Lake City, Utah, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Immunofarmacologia. Rio de Janeiro. RJ, Brasil.University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Immunofarmacologia. Rio de Janeiro. RJ, Brasil.Integrin aDb2 is the most recently identified member of the leukocyte, or b2, subfamily of integrin heterodimers. Its distribution and functions on human leukocytes have not been clearly defined and are controversial. We examined these issues and found that aDb2 is prominently expressed by leukocytes in whole blood from healthy human subjects, including most polymorphonuclear leukocytes and monocytes. We also found that aDb2 is displayed by leukocytes in the alveoli of uninjured and inflamed human lungs and by human monocyte-derived macrophages and dendritic cells, indicating broad myeloid expression. Using freshly-isolated human monocytes, we found that aDb2 delivers outside-in signals to pathways that regulate cell spreading and gene expression. Screening expression analysis followed by validation of candidate transcripts demonstrated that engagement of aDb2 induces mRNAs encoding inflammatory chemokines and cytokines and secretion of their protein products. Thus, aDb2 is a major member of the integrin repertoire of both circulating and tissue myeloid leukocytes in humans. Its broad expression and capacity for outside-in signaling indicate that it is likely to have important functions in clinical syndromes of infection, inflammation, and tissue injury.Tissue Myeloid LeukocytesMediates Inflammatory SignalingHuman CirculatingIntegrin αDβ2 (CD11d/CD18)info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10548/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALadriana_abreuetal_IOC_2014.pdfapplication/pdf757257https://www.arca.fiocruz.br/bitstream/icict/10548/2/adriana_abreuetal_IOC_2014.pdf545204c76680ad311754c7dd7e7c56bbMD52TEXTadriana_abreuetal_IOC_2014.pdf.txtadriana_abreuetal_IOC_2014.pdf.txtExtracted texttext/plain81070https://www.arca.fiocruz.br/bitstream/icict/10548/3/adriana_abreuetal_IOC_2014.pdf.txt35e0c6788c29b449467663f6aec16ab1MD53icict/105482022-06-24 13:08:46.723oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling
title Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling
spellingShingle Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling
Miyazaki, Yasunari
Tissue Myeloid Leukocytes
Mediates Inflammatory Signaling
Human Circulating
Integrin αDβ2 (CD11d/CD18)
title_short Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling
title_full Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling
title_fullStr Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling
title_full_unstemmed Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling
title_sort Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling
author Miyazaki, Yasunari
author_facet Miyazaki, Yasunari
Abreu, Adriana Vieira de
Harris, Estelle S
Shah, Amrapali M
Weyrich, Andrew S
Faria Neto, Hugo C. Castro
Zimmerman, Guy A
author_role author
author2 Abreu, Adriana Vieira de
Harris, Estelle S
Shah, Amrapali M
Weyrich, Andrew S
Faria Neto, Hugo C. Castro
Zimmerman, Guy A
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Miyazaki, Yasunari
Abreu, Adriana Vieira de
Harris, Estelle S
Shah, Amrapali M
Weyrich, Andrew S
Faria Neto, Hugo C. Castro
Zimmerman, Guy A
dc.subject.en.pt_BR.fl_str_mv Tissue Myeloid Leukocytes
Mediates Inflammatory Signaling
Human Circulating
Integrin αDβ2 (CD11d/CD18)
topic Tissue Myeloid Leukocytes
Mediates Inflammatory Signaling
Human Circulating
Integrin αDβ2 (CD11d/CD18)
description Tokyo Medical and Dental University. Department of Respiratory Medicine. Tokio, Japan.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-27T13:39:51Z
dc.date.available.fl_str_mv 2015-05-27T13:39:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MIYAZAKI, Yasunari et al. Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling. Plos One, v.11, n.9, 25p, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10548
dc.identifier.doi.pt_BR.fl_str_mv 0.1371/journal.pone.0112770
identifier_str_mv MIYAZAKI, Yasunari et al. Integrin aDb2 (CD11d/CD18) Is Expressed by Human Circulating and Tissue Myeloid Leukocytes and Mediates Inflammatory Signaling. Plos One, v.11, n.9, 25p, 2014.
0.1371/journal.pone.0112770
url https://www.arca.fiocruz.br/handle/icict/10548
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Plos One
publisher.none.fl_str_mv Plos One
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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