Leukocyte adhesion - a fundamental process in leukocyte physiology

Detalhes bibliográficos
Autor(a) principal: Gahmberg,C.G.
Data de Publicação: 1999
Outros Autores: Valmu,L., Tian,L., Kotovuori,P., Fagerholm,S., Kotovuori,A., Kantor,C., Hilden,T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500003
Resumo: Leukocyte adhesion is of pivotal functional importance. The adhesion involves several different adhesion molecules, the most important of which are the leukocyte ß2-integrins (CD11/CD18), the intercellular adhesion molecules, and the selectins. We and others have extensively studied the specificity and binding sites in the integrins and the intercellular adhesion molecules for their receptors and ligands. The integrins have to become activated to exert their functions but the possible mechanisms of activation remain poorly understood. Importantly, a few novel intercellular adhesion molecules have been recently described, which seem to function only in specific tissues. Furthermore, it is becoming increasingly apparent that changes in integrins and intercellular adhesion molecules are associated with a number of acute and chronic diseases.
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spelling Leukocyte adhesion - a fundamental process in leukocyte physiologyleukocyteadhesionintegrinICAMmembraneglycoproteinLeukocyte adhesion is of pivotal functional importance. The adhesion involves several different adhesion molecules, the most important of which are the leukocyte ß2-integrins (CD11/CD18), the intercellular adhesion molecules, and the selectins. We and others have extensively studied the specificity and binding sites in the integrins and the intercellular adhesion molecules for their receptors and ligands. The integrins have to become activated to exert their functions but the possible mechanisms of activation remain poorly understood. Importantly, a few novel intercellular adhesion molecules have been recently described, which seem to function only in specific tissues. Furthermore, it is becoming increasingly apparent that changes in integrins and intercellular adhesion molecules are associated with a number of acute and chronic diseases.Associação Brasileira de Divulgação Científica1999-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500003Brazilian Journal of Medical and Biological Research v.32 n.5 1999reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1999000500003info:eu-repo/semantics/openAccessGahmberg,C.G.Valmu,L.Tian,L.Kotovuori,P.Fagerholm,S.Kotovuori,A.Kantor,C.Hilden,T.eng1999-04-27T00:00:00Zoai:scielo:S0100-879X1999000500003Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1999-04-27T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Leukocyte adhesion - a fundamental process in leukocyte physiology
title Leukocyte adhesion - a fundamental process in leukocyte physiology
spellingShingle Leukocyte adhesion - a fundamental process in leukocyte physiology
Gahmberg,C.G.
leukocyte
adhesion
integrin
ICAM
membrane
glycoprotein
title_short Leukocyte adhesion - a fundamental process in leukocyte physiology
title_full Leukocyte adhesion - a fundamental process in leukocyte physiology
title_fullStr Leukocyte adhesion - a fundamental process in leukocyte physiology
title_full_unstemmed Leukocyte adhesion - a fundamental process in leukocyte physiology
title_sort Leukocyte adhesion - a fundamental process in leukocyte physiology
author Gahmberg,C.G.
author_facet Gahmberg,C.G.
Valmu,L.
Tian,L.
Kotovuori,P.
Fagerholm,S.
Kotovuori,A.
Kantor,C.
Hilden,T.
author_role author
author2 Valmu,L.
Tian,L.
Kotovuori,P.
Fagerholm,S.
Kotovuori,A.
Kantor,C.
Hilden,T.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gahmberg,C.G.
Valmu,L.
Tian,L.
Kotovuori,P.
Fagerholm,S.
Kotovuori,A.
Kantor,C.
Hilden,T.
dc.subject.por.fl_str_mv leukocyte
adhesion
integrin
ICAM
membrane
glycoprotein
topic leukocyte
adhesion
integrin
ICAM
membrane
glycoprotein
description Leukocyte adhesion is of pivotal functional importance. The adhesion involves several different adhesion molecules, the most important of which are the leukocyte ß2-integrins (CD11/CD18), the intercellular adhesion molecules, and the selectins. We and others have extensively studied the specificity and binding sites in the integrins and the intercellular adhesion molecules for their receptors and ligands. The integrins have to become activated to exert their functions but the possible mechanisms of activation remain poorly understood. Importantly, a few novel intercellular adhesion molecules have been recently described, which seem to function only in specific tissues. Furthermore, it is becoming increasingly apparent that changes in integrins and intercellular adhesion molecules are associated with a number of acute and chronic diseases.
publishDate 1999
dc.date.none.fl_str_mv 1999-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X1999000500003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.32 n.5 1999
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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