Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1128/CVI.00475-07 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28317 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil. |
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Fernandes, Andréa Aparecida MoraisCarvalho, Leonardo José de MouraZanini, Graziela MariaVentura, Ana Maria Revorêdo da SilvaSouza, José MariaCotias, Paulo MarceloSilva Filho, Isaac LimaDaniel-Ribeiro, Cláudio Tadeu2018-08-23T12:44:25Z2018-08-23T12:44:25Z2008FERNANDES, Andréa Aparecida Morais; et al. Similar Cytokine Responses and Degrees of Anemia in Patients with Plasmodium falciparum and Plasmodium vivax Infections in the Brazilian Amazon Region. Clinical and Vaccine Immunology, v.15, n.4, p.650-658, Apr. 2008.1556-6811https://www.arca.fiocruz.br/handle/icict/2831710.1128/CVI.00475-071556-679XengAmerican Society for MicrobiologyPlasmodium falciparumInfecçãoAnemiaCitocinasAmazônia BrasileiraPlasmodium falciparumPlasmodium vivaxInfectionsAnemiacytokinesBrazilian Amazon RegionSimilar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon regioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.IInstituto Evandro Chagas. Secretaria de Vigilância em Saúde. Ensaios Clínicos Ambulatoriais e Laboratoriais de Malária. Belém, PA, Brasil.Instituto Evandro Chagas. Secretaria de Vigilância em Saúde. Ensaios Clínicos Ambulatoriais e Laboratoriais de Malária. Belém, PA, Brasil.l.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.The mechanisms of malarial anemia induction are poorly understood, but cytokines and autoantibodies are considered to play important roles. This work aimed at evaluating the degree of anemia and the plasmatic profile of the cytokines tumor necrosis factor alpha (TNF-alpha), gamma interferon (IFN-gamma), interleukin-12 (IL-12), migration inhibitory factor (MIF), and IL-10 and the monocyte chemotactic protein-1 (MCP-1) chemokine, as well as evaluating the presence of antibodies directed to components of the normal erythrocyte membrane and to cardiolipin in individuals with malaria from the Brazilian Amazon. No difference was observed in the frequency of anemia between patients infected by Plasmodium vivax and those infected by Plasmodium falciparum, and there was no relationship between the levels of parasitemia and the manifestations of anemia in P. vivax and P. falciparum patients. Significant increases in the concentrations of TNF-alpha, IFN-gamma, MIF, and MCP-1 were observed in patients with P. falciparum and P. vivax malaria, whereas the concentrations of IL-10 was increased only in patients with P. vivax infection. Higher concentrations of IL-12 and IL-10 were observed in the P. falciparum anemic patients, while for TNF-alpha this profile was observed in the nonanemic ones. P. vivax-infected and P. falciparum-infected patients with positive immunoglobulin M (IgM) or IgM and IgG responses, respectively, against blood-stage forms of the parasites had significantly lower hemoglobin levels than did those with negative responses. There was no correlation between the presence of anti-erythrocyte and anti-cardiolipin antibodies and the presence or intensity of the anemia. Our data suggest that in areas of low endemicity and unstable transmission of malaria, P. vivax and P. falciparum infections present similar characteristics in terms of the induction of anemia and cytokine responses.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28317/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALandrea_fernandes_etal_IOC_2009.pdfandrea_fernandes_etal_IOC_2009.pdfapplication/pdf799926https://www.arca.fiocruz.br/bitstream/icict/28317/2/andrea_fernandes_etal_IOC_2009.pdf8df635d6d4ac178ebde2bf8d772613fdMD52TEXTandrea_fernandes_etal_IOC_2009.pdf.txtandrea_fernandes_etal_IOC_2009.pdf.txtExtracted texttext/plain56565https://www.arca.fiocruz.br/bitstream/icict/28317/3/andrea_fernandes_etal_IOC_2009.pdf.txtd1e650583e0a3531b83f034f89b1f52fMD53icict/283172018-08-24 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| dc.title.pt_BR.fl_str_mv |
Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region |
| title |
Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region |
| spellingShingle |
Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region Fernandes, Andréa Aparecida Morais Plasmodium falciparum Infecção Anemia Citocinas Amazônia Brasileira Plasmodium falciparum Plasmodium vivax Infections Anemia cytokines Brazilian Amazon Region |
| title_short |
Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region |
| title_full |
Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region |
| title_fullStr |
Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region |
| title_full_unstemmed |
Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region |
| title_sort |
Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region |
| author |
Fernandes, Andréa Aparecida Morais |
| author_facet |
Fernandes, Andréa Aparecida Morais Carvalho, Leonardo José de Moura Zanini, Graziela Maria Ventura, Ana Maria Revorêdo da Silva Souza, José Maria Cotias, Paulo Marcelo Silva Filho, Isaac Lima Daniel-Ribeiro, Cláudio Tadeu |
| author_role |
author |
| author2 |
Carvalho, Leonardo José de Moura Zanini, Graziela Maria Ventura, Ana Maria Revorêdo da Silva Souza, José Maria Cotias, Paulo Marcelo Silva Filho, Isaac Lima Daniel-Ribeiro, Cláudio Tadeu |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fernandes, Andréa Aparecida Morais Carvalho, Leonardo José de Moura Zanini, Graziela Maria Ventura, Ana Maria Revorêdo da Silva Souza, José Maria Cotias, Paulo Marcelo Silva Filho, Isaac Lima Daniel-Ribeiro, Cláudio Tadeu |
| dc.subject.other.pt_BR.fl_str_mv |
Plasmodium falciparum Infecção Anemia Citocinas Amazônia Brasileira |
| topic |
Plasmodium falciparum Infecção Anemia Citocinas Amazônia Brasileira Plasmodium falciparum Plasmodium vivax Infections Anemia cytokines Brazilian Amazon Region |
| dc.subject.en.pt_BR.fl_str_mv |
Plasmodium falciparum Plasmodium vivax Infections Anemia cytokines Brazilian Amazon Region |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil. |
| publishDate |
2008 |
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2008 |
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2018-08-23T12:44:25Z |
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2018-08-23T12:44:25Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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FERNANDES, Andréa Aparecida Morais; et al. Similar Cytokine Responses and Degrees of Anemia in Patients with Plasmodium falciparum and Plasmodium vivax Infections in the Brazilian Amazon Region. Clinical and Vaccine Immunology, v.15, n.4, p.650-658, Apr. 2008. |
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https://www.arca.fiocruz.br/handle/icict/28317 |
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1556-6811 |
| dc.identifier.doi.none.fl_str_mv |
10.1128/CVI.00475-07 |
| dc.identifier.eissn.none.fl_str_mv |
1556-679X |
| identifier_str_mv |
FERNANDES, Andréa Aparecida Morais; et al. Similar Cytokine Responses and Degrees of Anemia in Patients with Plasmodium falciparum and Plasmodium vivax Infections in the Brazilian Amazon Region. Clinical and Vaccine Immunology, v.15, n.4, p.650-658, Apr. 2008. 1556-6811 10.1128/CVI.00475-07 1556-679X |
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American Society for Microbiology |
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American Society for Microbiology |
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