Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response

Detalhes bibliográficos
Autor(a) principal: Gomes, Larissa Rodrigues
Data de Publicação: 2013
Outros Autores: Totino, Paulo Renato Rivas, Sanchez, Maria Carmen Arroyo, Daniel, Elsa Paula da Silva Kaingona, Macedo, Cristiana Santos de, Fortes, Filomeno, Coura, José Rodrigues, Santi, Silvia Maria Di, Werneck, Guilherme Loureiro, Mutis, Martha Cecilia Suárez, Cruz, Maria de Fátima Ferreira-da, Daniel-Ribeiro, Cláudio Tadeu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11705
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. 2Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.
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spelling Gomes, Larissa RodriguesTotino, Paulo Renato RivasSanchez, Maria Carmen ArroyoDaniel, Elsa Paula da Silva KaingonaMacedo, Cristiana Santos deFortes, FilomenoCoura, José RodriguesSanti, Silvia Maria DiWerneck, Guilherme LoureiroMutis, Martha Cecilia SuárezCruz, Maria de Fátima Ferreira-daDaniel-Ribeiro, Cláudio Tadeu2015-09-21T17:25:23Z2015-09-21T17:25:23Z2013GOMES, Larissa Rodrigues; et al. Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response. Mem Inst Oswaldo Cruz, v.108, n.6, p. 796-800, Sept. 2013.1678-8060https://www.arca.fiocruz.br/handle/icict/1170510.1590/0074-0276108062013018engFundação Oswaldo CruzAsymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody responseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. 2Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. 2Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Instituto de Medicina Tropical de São Paulo. Laboratório de Soroepidemiologia e Imunobiologia, São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. 2Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil / Hospital Central Dr Antônio Agostinho Neto. Lubango, Angola.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Saúde Pública. Luanda, Angola.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.Superintendência de Controle de Endemias. Centro de Pesquisas em Malária. São Paulo, SP, BrasilUniversidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Núcleo de Estudos em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. 2Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. 2Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.Anti-glycosylphosphatidylinositol (GPI) antibodies (Abs) may reflect and mediate, at least partially, anti-disease immunity in malaria by neutralising the toxic effect of parasitic GPI. Thus, we assessed the anti-GPI Ab response in asymptomatic individuals living in an area of the Brazilian Amazon that has a high level of malaria transmission. For comparative purposes, we also investigated the Ab response to a crude extract prepared from Plasmodium falciparum, the merozoite surface protein (MSP)3 antigen of P. falciparum and the MSP 1 antigen of Plasmodium vivax (PvMSP1-19) in these individuals and in Angolan patients with acute malaria. Our data suggest that the Ab response against P. falciparum GPI is not associated with P. falciparum asymptomatic infection in individuals who have been chronically exposed to malaria in the Brazilian Amazon. However, this Ab response could be related to ongoing parasitaemia (as was previously shown) in the Angolan patients. In addition, our data show that PvMSP1-19 may be a good marker antigen to reflect previous exposure to Plasmodium in areas that have a high transmission rate of P. vivax.Plasmodium falciparumPlasmodium vivaxGlycosylphosphatidylinositolAsymptomatic infectionBrazilian AmazonAngolaInfecções AssintomáticasGlicosilfosfatidilinositóisPlasmodium falciparumPlasmodium vivaxinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11705/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALmarta_mutiz_etal_IOC_2013.pdfapplication/pdf368506https://www.arca.fiocruz.br/bitstream/icict/11705/2/marta_mutiz_etal_IOC_2013.pdfc5ab58aafec21968dad2c084e468ba0eMD52TEXTmarta_mutiz_etal_IOC_2013.pdf.txtmarta_mutiz_etal_IOC_2013.pdf.txtExtracted texttext/plain28069https://www.arca.fiocruz.br/bitstream/icict/11705/3/marta_mutiz_etal_IOC_2013.pdf.txt1015065755d9a7d524e27bb7e261bab0MD53icict/117052022-06-24 12:18:54.209oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:18:54Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response
title Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response
spellingShingle Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response
Gomes, Larissa Rodrigues
Plasmodium falciparum
Plasmodium vivax
Glycosylphosphatidylinositol
Asymptomatic infection
Brazilian Amazon
Angola
Infecções Assintomáticas
Glicosilfosfatidilinositóis
Plasmodium falciparum
Plasmodium vivax
title_short Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response
title_full Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response
title_fullStr Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response
title_full_unstemmed Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response
title_sort Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response
author Gomes, Larissa Rodrigues
author_facet Gomes, Larissa Rodrigues
Totino, Paulo Renato Rivas
Sanchez, Maria Carmen Arroyo
Daniel, Elsa Paula da Silva Kaingona
Macedo, Cristiana Santos de
Fortes, Filomeno
Coura, José Rodrigues
Santi, Silvia Maria Di
Werneck, Guilherme Loureiro
Mutis, Martha Cecilia Suárez
Cruz, Maria de Fátima Ferreira-da
Daniel-Ribeiro, Cláudio Tadeu
author_role author
author2 Totino, Paulo Renato Rivas
Sanchez, Maria Carmen Arroyo
Daniel, Elsa Paula da Silva Kaingona
Macedo, Cristiana Santos de
Fortes, Filomeno
Coura, José Rodrigues
Santi, Silvia Maria Di
Werneck, Guilherme Loureiro
Mutis, Martha Cecilia Suárez
Cruz, Maria de Fátima Ferreira-da
Daniel-Ribeiro, Cláudio Tadeu
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes, Larissa Rodrigues
Totino, Paulo Renato Rivas
Sanchez, Maria Carmen Arroyo
Daniel, Elsa Paula da Silva Kaingona
Macedo, Cristiana Santos de
Fortes, Filomeno
Coura, José Rodrigues
Santi, Silvia Maria Di
Werneck, Guilherme Loureiro
Mutis, Martha Cecilia Suárez
Cruz, Maria de Fátima Ferreira-da
Daniel-Ribeiro, Cláudio Tadeu
dc.subject.en.pt_BR.fl_str_mv Plasmodium falciparum
Plasmodium vivax
Glycosylphosphatidylinositol
Asymptomatic infection
Brazilian Amazon
Angola
topic Plasmodium falciparum
Plasmodium vivax
Glycosylphosphatidylinositol
Asymptomatic infection
Brazilian Amazon
Angola
Infecções Assintomáticas
Glicosilfosfatidilinositóis
Plasmodium falciparum
Plasmodium vivax
dc.subject.decs.pt_BR.fl_str_mv Infecções Assintomáticas
Glicosilfosfatidilinositóis
Plasmodium falciparum
Plasmodium vivax
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. 2Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2015-09-21T17:25:23Z
dc.date.available.fl_str_mv 2015-09-21T17:25:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, Larissa Rodrigues; et al. Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response. Mem Inst Oswaldo Cruz, v.108, n.6, p. 796-800, Sept. 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11705
dc.identifier.issn.pt_BR.fl_str_mv 1678-8060
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/0074-0276108062013018
identifier_str_mv GOMES, Larissa Rodrigues; et al. Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response. Mem Inst Oswaldo Cruz, v.108, n.6, p. 796-800, Sept. 2013.
1678-8060
10.1590/0074-0276108062013018
url https://www.arca.fiocruz.br/handle/icict/11705
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
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