Dating the Cryptococcus gattii dispersal to the North American Pacific Northwest

Detalhes bibliográficos
Autor(a) principal: Roe, Chandler C.
Data de Publicação: 2018
Outros Autores: Bowers, Jolene, Oltean, Hanna, DeBess, Emilio, Dufresne, Philippe J., McBurney, Scott, Overy, David P., Wanke, Bodo, Lysen, Colleen, Chiller, Tom, Meyer, Wieland, Thompson, George R., Lockhart, Shawn R., Hepp, Crystal M., Engelthaler, David M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33673
Resumo: Translational Genomics Research Institute. Flagstaff, AZ, USA.
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spelling Roe, Chandler C.Bowers, JoleneOltean, HannaDeBess, EmilioDufresne, Philippe J.McBurney, ScottOvery, David P.Wanke, BodoLysen, ColleenChiller, TomMeyer, WielandThompson, George R.Lockhart, Shawn R.Hepp, Crystal M.Engelthaler, David M.2019-06-26T13:33:30Z2019-06-26T13:33:30Z2018ROE, Chandler C. et al. Data set characterizing the systemic alterations of microvascular reactivity and capillary density, in patients presenting with infective endocarditis. Data in Brief, v. 18, p. 480-491, 2018.2379-5042https://www.arca.fiocruz.br/handle/icict/3367310.1128/mSphere.00499-172379-5042engAmerican Society for MicrobiologyDating the Cryptococcus gattii dispersal to the North American Pacific Northwestinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTranslational Genomics Research Institute. Flagstaff, AZ, USA.Translational Genomics Research Institute. Flagstaff, AZ, USA.Washington State Department of Health. Shoreline, WA, USA.Oregon Health Authority. Public Health Division. Salem, OR, USA.Institut National de Santé Publique du Québec. Laboratoire de Santé Publique du Québec. Charlottetown, PE, Canada.Canadian Wildlife Health Cooperative. Charlottetown, PE, Canada / University of Prince Edward Island. Atlantic Veterinary College. Charlottetown, PE, Canada.Canadian Wildlife Health Cooperative. Charlottetown, PE, Canada / University of Prince Edward Island. Atlantic Veterinary College. Charlottetown, PE, Canada / Agriculture and Agrifood Canada. Ottawa Research and Development Centre. Ottawa, ON, Canada.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Centers for Disease Control and Prevention. Mycotic Disease Branch. Atlanta, GA, USA.Centers for Disease Control and Prevention. Mycotic Disease Branch. Atlanta, GA, USA.Westmead Institute. Center for Infectious Diseases and Microbiology. Molecular Mycology Research Laboratory. Sydney, NSW, Australia / University of Sydney. Marie Bashir Institute for Emerging Infections and Biosecurity. Sydney, NSW, Australia / University of Sydney. Westmead Clinical School. Sydney, NSW, Australia / University of Sydney. Sydney Medical School. Sydney, NSW, Australia / University of Sydney. Westmead Institute for Medical Research. Sydney, NSW, Australia / University of Sydney. Westmead Hospital. Sydney, NSW, Australia.University of California, Davis. Davis, CA, USA.Centers for Disease Control and Prevention. Mycotic Disease Branch. Atlanta, GA, USA.Northern Arizona University. School of Informatics, Computing, and Cyber Systems. Flagstaff, AZ, USATranslational Genomics Research Institute. Flagstaff, AZ, USA.The emergence of Cryptococcus gattii, previously regarded as a predominantly tropical pathogen, in the temperate climate of the North American Pacific Northwest (PNW) in 1999 prompted several questions. The most prevalent among these was the timing of the introduction of this pathogen to this novel environment. Here, we infer tip-dated timing estimates for the three clonal C. gattii populations observed in the PNW, VGIIa, VGIIb, and VGIIc, based on whole-genome sequencing of 134 C. gattii isolates and using Bayesian evolutionary analysis by sampling trees (BEAST). We estimated the nucleotide substitution rate for each lineage (1.59 × 10-8, 1.59 × 10-8, and 2.70 × 10-8, respectively) to be an order of magnitude higher than common neutral fungal mutation rates (2.0 × 10-9), indicating a microevolutionary rate (e.g., successive clonal generations in a laboratory) in comparison to a species' slower, macroevolutionary rate (e.g., when using fossil records). The clonal nature of the PNW C. gattii emergence over a narrow number of years would therefore possibly explain our higher mutation rates. Our results suggest that the mean time to most recent common ancestor for all three sublineages occurred within the last 60 to 100 years. While the cause of C. gattii dispersal to the PNW is still unclear, our research estimates that the arrival is neither ancient nor very recent (i.e., <25 years ago), making a strong case for an anthropogenic introduction. IMPORTANCE The recent emergence of the pathogenic fungus Cryptococcus gattii in the Pacific Northwest (PNW) resulted in numerous investigations into the epidemiological and enzootic impacts, as well as multiple genomic explorations of the three primary molecular subtypes of the fungus that were discovered. These studies lead to the general conclusion that the subtypes identified likely emerged out of Brazil. Here, we conducted genomic dating analyses to determine the ages of the various lineages seen in the PNW and propose hypothetical causes for the dispersal events. Bayesian evolutionary analysis strongly suggests that these independent fungal populations in the PNW are all 60 to 100 years old, providing a timing that is subsequent to the opening of the Panama Canal, which allowed for more direct shipping between Brazil and the western North American coastline, a possible driving event for these fungal translocation events.CryptococcusGenomicsMolecular epidemiologyMycologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Dating the Cryptococcus gattii dispersal to the North American Pacific Northwest
title Dating the Cryptococcus gattii dispersal to the North American Pacific Northwest
spellingShingle Dating the Cryptococcus gattii dispersal to the North American Pacific Northwest
Roe, Chandler C.
Cryptococcus
Genomics
Molecular epidemiology
Mycology
title_short Dating the Cryptococcus gattii dispersal to the North American Pacific Northwest
title_full Dating the Cryptococcus gattii dispersal to the North American Pacific Northwest
title_fullStr Dating the Cryptococcus gattii dispersal to the North American Pacific Northwest
title_full_unstemmed Dating the Cryptococcus gattii dispersal to the North American Pacific Northwest
title_sort Dating the Cryptococcus gattii dispersal to the North American Pacific Northwest
author Roe, Chandler C.
author_facet Roe, Chandler C.
Bowers, Jolene
Oltean, Hanna
DeBess, Emilio
Dufresne, Philippe J.
McBurney, Scott
Overy, David P.
Wanke, Bodo
Lysen, Colleen
Chiller, Tom
Meyer, Wieland
Thompson, George R.
Lockhart, Shawn R.
Hepp, Crystal M.
Engelthaler, David M.
author_role author
author2 Bowers, Jolene
Oltean, Hanna
DeBess, Emilio
Dufresne, Philippe J.
McBurney, Scott
Overy, David P.
Wanke, Bodo
Lysen, Colleen
Chiller, Tom
Meyer, Wieland
Thompson, George R.
Lockhart, Shawn R.
Hepp, Crystal M.
Engelthaler, David M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Roe, Chandler C.
Bowers, Jolene
Oltean, Hanna
DeBess, Emilio
Dufresne, Philippe J.
McBurney, Scott
Overy, David P.
Wanke, Bodo
Lysen, Colleen
Chiller, Tom
Meyer, Wieland
Thompson, George R.
Lockhart, Shawn R.
Hepp, Crystal M.
Engelthaler, David M.
dc.subject.en.pt_BR.fl_str_mv Cryptococcus
Genomics
Molecular epidemiology
Mycology
topic Cryptococcus
Genomics
Molecular epidemiology
Mycology
description Translational Genomics Research Institute. Flagstaff, AZ, USA.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-06-26T13:33:30Z
dc.date.available.fl_str_mv 2019-06-26T13:33:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROE, Chandler C. et al. Data set characterizing the systemic alterations of microvascular reactivity and capillary density, in patients presenting with infective endocarditis. Data in Brief, v. 18, p. 480-491, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33673
dc.identifier.issn.pt_BR.fl_str_mv 2379-5042
dc.identifier.doi.none.fl_str_mv 10.1128/mSphere.00499-17
dc.identifier.eissn.none.fl_str_mv 2379-5042
identifier_str_mv ROE, Chandler C. et al. Data set characterizing the systemic alterations of microvascular reactivity and capillary density, in patients presenting with infective endocarditis. Data in Brief, v. 18, p. 480-491, 2018.
2379-5042
10.1128/mSphere.00499-17
url https://www.arca.fiocruz.br/handle/icict/33673
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33673/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/33673/2/ve_Roe_Chandler_etal_INI_2018.pdf
https://www.arca.fiocruz.br/bitstream/icict/33673/3/ve_Roe_Chandler_etal_INI_2018.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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