A preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in markets

Detalhes bibliográficos
Autor(a) principal: Pedrete, Thaís de Almeida
Data de Publicação: 2021
Outros Autores: Carmo, Julianderson de Oliveira dos Santos, Barreto, Emiliano de Oliveir, Moreira, Josino Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48185
Resumo: Universidade do Estado do Rio de Janeiro. Centro Biomédico. Instituto de Biologia Roberto Alcantara Gomes. Rio de Janeiro, RJ, Brasil.
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spelling Pedrete, Thaís de AlmeidaCarmo, Julianderson de Oliveira dos SantosBarreto, Emiliano de OliveirMoreira, Josino Costa2021-07-12T20:19:11Z2021-07-12T20:19:11Z2021PEDRETE, Thaís de Almeida et al. A preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in markets. Revista Fitos, v. 15, n. 1, p. 11-21, Mar. 2021.1808-9569https://www.arca.fiocruz.br/handle/icict/4818510.32712/2446-4775.2021.8972446-4775engFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e SaúdeA preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in marketsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Centro Biomédico. Instituto de Biologia Roberto Alcantara Gomes. Rio de Janeiro, RJ, Brasil.Universidade Federal de Alagoas. Instituto de Ciências Biológicas e da Saúde. Laboratório de Biologia Celular. Maceió, AL, Brasil.Universidade Federal de Alagoas. Instituto de Ciências Biológicas e da Saúde. Laboratório de Biologia Celular. Maceió, AL, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.The use of plants and their products for medical treatment is a quite common procedure in Brazil, especially for treatment of diabetes. In fact, several plants can demonstrate hypoglycemic effects in vitro assays. However, the use for human treatment requires the knowledge of their toxicological properties. The aim of this study was to evaluate the effect of protein extracts of Chrysobalanus icaco collected from natural habitats and of Eugenia astringens acquired from the market in Rio de Janeiro on the viability and migration of fibroblasts. E. astringens has a similar morphology as C. icaco and it is sold as Chrysobalanus in a popular market. Being a different plant, E. astringens expresses different proteins, and its protein extract has proved to possess higher toxic properties than C. icaco does. Cytotoxicity assays indicated that, as the protein extract concentration increases, fibroblast viability decreases. Only the E. astringens extract displayed cytotoxicity at all concentrations, in addition to reduced fibroblast migration. The results obtained in this study demonstrates that it is necessary integrative policies for rational use of medicinal plants and their commercialization, since the current use of medicinal plants may be inadequate, and it is of great importance for Public Health.CytotoxicityProtein extractHypoglycemic plantChrysobalanus icacoUgenia astringensinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/48185/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALt_d_a_et_all.pdfapplication/pdf819862https://www.arca.fiocruz.br/bitstream/icict/48185/2/t_d_a_et_all.pdf58c5a41eba14156c64b1dc70808f8cabMD52TEXTt_d_a_et_all.pdf.txtt_d_a_et_all.pdf.txtExtracted texttext/plain31796https://www.arca.fiocruz.br/bitstream/icict/48185/3/t_d_a_et_all.pdf.txt8e7ad9ea6473720bbd732b7b8f35ee6eMD53icict/481852022-12-08 13:36:10.992oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-12-08T16:36:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv A preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in markets
title A preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in markets
spellingShingle A preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in markets
Pedrete, Thaís de Almeida
Cytotoxicity
Protein extract
Hypoglycemic plant
Chrysobalanus icaco
Ugenia astringens
title_short A preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in markets
title_full A preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in markets
title_fullStr A preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in markets
title_full_unstemmed A preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in markets
title_sort A preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in markets
author Pedrete, Thaís de Almeida
author_facet Pedrete, Thaís de Almeida
Carmo, Julianderson de Oliveira dos Santos
Barreto, Emiliano de Oliveir
Moreira, Josino Costa
author_role author
author2 Carmo, Julianderson de Oliveira dos Santos
Barreto, Emiliano de Oliveir
Moreira, Josino Costa
author2_role author
author
author
dc.contributor.author.fl_str_mv Pedrete, Thaís de Almeida
Carmo, Julianderson de Oliveira dos Santos
Barreto, Emiliano de Oliveir
Moreira, Josino Costa
dc.subject.en.en_US.fl_str_mv Cytotoxicity
Protein extract
Hypoglycemic plant
Chrysobalanus icaco
Ugenia astringens
topic Cytotoxicity
Protein extract
Hypoglycemic plant
Chrysobalanus icaco
Ugenia astringens
description Universidade do Estado do Rio de Janeiro. Centro Biomédico. Instituto de Biologia Roberto Alcantara Gomes. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-07-12T20:19:11Z
dc.date.available.fl_str_mv 2021-07-12T20:19:11Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PEDRETE, Thaís de Almeida et al. A preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in markets. Revista Fitos, v. 15, n. 1, p. 11-21, Mar. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48185
dc.identifier.issn.none.fl_str_mv 1808-9569
dc.identifier.doi.none.fl_str_mv 10.32712/2446-4775.2021.897
dc.identifier.eissn.none.fl_str_mv 2446-4775
identifier_str_mv PEDRETE, Thaís de Almeida et al. A preliminary study of the cytotoxicity of the protein extract of “abajerú” commercialized in markets. Revista Fitos, v. 15, n. 1, p. 11-21, Mar. 2021.
1808-9569
10.32712/2446-4775.2021.897
2446-4775
url https://www.arca.fiocruz.br/handle/icict/48185
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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