A preliminary study of the cytotoxicity of the protein extract of abajerú commercialized in markets
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Fitos |
Texto Completo: | https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/897 |
Resumo: | The use of plants and their products for medical treatment is a quite common procedure in Brazil, especially for treatment of diabetes. In fact, several plants can demonstrate hypoglycemic effects in vitro assays. However, the use for human treatment requires the knowledge of their toxicological properties. The aim of this study was to evaluate the effect of protein extracts of Chrysobalanus icaco collected from natural habitats and of Eugenia astringens acquired from the market in Rio de Janeiro on the viability and migration of fibroblasts. E. astringens has a similar morphology as C. icaco and it is sold as Chrysobalanus in a popular market. Being a different plant, E. astringens expresses different proteins, and its protein extract has proved to possess higher toxic properties than C. icaco does. Cytotoxicity assays indicated that, as the protein extract concentration increases, fibroblast viability decreases. Only the E. astringens extract displayed cytotoxicity at all concentrations, in addition to reduced fibroblast migration. The results obtained in this study demonstrates that it is necessary integrative policies for rational use of medicinal plants and their commercialization, since the current use of medicinal plants may be inadequate, and it is of great importance for Public Health. |
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A preliminary study of the cytotoxicity of the protein extract of abajerú commercialized in marketsA preliminary study of the cytotoxicity of the protein extract of abajerú commercialized in marketsCytotoxicityProtein extractHypoglycemic plantChrysobalanus icacoEugenia astringensThe use of plants and their products for medical treatment is a quite common procedure in Brazil, especially for treatment of diabetes. In fact, several plants can demonstrate hypoglycemic effects in vitro assays. However, the use for human treatment requires the knowledge of their toxicological properties. The aim of this study was to evaluate the effect of protein extracts of Chrysobalanus icaco collected from natural habitats and of Eugenia astringens acquired from the market in Rio de Janeiro on the viability and migration of fibroblasts. E. astringens has a similar morphology as C. icaco and it is sold as Chrysobalanus in a popular market. Being a different plant, E. astringens expresses different proteins, and its protein extract has proved to possess higher toxic properties than C. icaco does. Cytotoxicity assays indicated that, as the protein extract concentration increases, fibroblast viability decreases. Only the E. astringens extract displayed cytotoxicity at all concentrations, in addition to reduced fibroblast migration. The results obtained in this study demonstrates that it is necessary integrative policies for rational use of medicinal plants and their commercialization, since the current use of medicinal plants may be inadequate, and it is of great importance for Public Health.The use of plants and their products for medical treatment is a quite common procedure in Brazil, especially for treatment of diabetes. In fact, several plants can demonstrate hypoglycemic effects in vitro assays. However, the use for human treatment requires the knowledge of their toxicological properties. The aim of this study was to evaluate the effect of protein extracts of Chrysobalanus icaco collected from natural habitats and of Eugenia astringens acquired from the market in Rio de Janeiro on the viability and migration of fibroblasts. E. astringens has a similar morphology as C. icaco and it is sold as Chrysobalanus in a popular market. Being a different plant, E. astringens expresses different proteins, and its protein extract has proved to possess higher toxic properties than C. icaco does. Cytotoxicity assays indicated that, as the protein extract concentration increases, fibroblast viability decreases. Only the E. astringens extract displayed cytotoxicity at all concentrations, in addition to reduced fibroblast migration. The results obtained in this study demonstrates that it is necessary integrative policies for rational use of medicinal plants and their commercialization, since the current use of medicinal plants may be inadequate, and it is of great importance for Public Health.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2021-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmltext/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/89710.32712/2446-4775.2021.897Revista Fitos; Vol. 15 No. 1 (2021); 11-21Revista Fitos; Vol. 15 Núm. 1 (2021); 11-21Revista Fitos; v. 15 n. 1 (2021); 11-212446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/897/767https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/897/768https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/897/821Copyright (c) 2021 Revista Fitoshttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessPedrete, Thaís de AlmeidaCarmo, Julianderson de Oliveira dos SantosBarreto, Emiliano de OliveiraMoreira, Josino Costa2021-05-14T13:26:53Zoai:ojs.revistafitos.far.fiocruz.br:article/897Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2021-05-14T13:26:53Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.none.fl_str_mv |
A preliminary study of the cytotoxicity of the protein extract of abajerú commercialized in markets A preliminary study of the cytotoxicity of the protein extract of abajerú commercialized in markets |
title |
A preliminary study of the cytotoxicity of the protein extract of abajerú commercialized in markets |
spellingShingle |
A preliminary study of the cytotoxicity of the protein extract of abajerú commercialized in markets Pedrete, Thaís de Almeida Cytotoxicity Protein extract Hypoglycemic plant Chrysobalanus icaco Eugenia astringens |
title_short |
A preliminary study of the cytotoxicity of the protein extract of abajerú commercialized in markets |
title_full |
A preliminary study of the cytotoxicity of the protein extract of abajerú commercialized in markets |
title_fullStr |
A preliminary study of the cytotoxicity of the protein extract of abajerú commercialized in markets |
title_full_unstemmed |
A preliminary study of the cytotoxicity of the protein extract of abajerú commercialized in markets |
title_sort |
A preliminary study of the cytotoxicity of the protein extract of abajerú commercialized in markets |
author |
Pedrete, Thaís de Almeida |
author_facet |
Pedrete, Thaís de Almeida Carmo, Julianderson de Oliveira dos Santos Barreto, Emiliano de Oliveira Moreira, Josino Costa |
author_role |
author |
author2 |
Carmo, Julianderson de Oliveira dos Santos Barreto, Emiliano de Oliveira Moreira, Josino Costa |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Pedrete, Thaís de Almeida Carmo, Julianderson de Oliveira dos Santos Barreto, Emiliano de Oliveira Moreira, Josino Costa |
dc.subject.por.fl_str_mv |
Cytotoxicity Protein extract Hypoglycemic plant Chrysobalanus icaco Eugenia astringens |
topic |
Cytotoxicity Protein extract Hypoglycemic plant Chrysobalanus icaco Eugenia astringens |
description |
The use of plants and their products for medical treatment is a quite common procedure in Brazil, especially for treatment of diabetes. In fact, several plants can demonstrate hypoglycemic effects in vitro assays. However, the use for human treatment requires the knowledge of their toxicological properties. The aim of this study was to evaluate the effect of protein extracts of Chrysobalanus icaco collected from natural habitats and of Eugenia astringens acquired from the market in Rio de Janeiro on the viability and migration of fibroblasts. E. astringens has a similar morphology as C. icaco and it is sold as Chrysobalanus in a popular market. Being a different plant, E. astringens expresses different proteins, and its protein extract has proved to possess higher toxic properties than C. icaco does. Cytotoxicity assays indicated that, as the protein extract concentration increases, fibroblast viability decreases. Only the E. astringens extract displayed cytotoxicity at all concentrations, in addition to reduced fibroblast migration. The results obtained in this study demonstrates that it is necessary integrative policies for rational use of medicinal plants and their commercialization, since the current use of medicinal plants may be inadequate, and it is of great importance for Public Health. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-31 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/897 10.32712/2446-4775.2021.897 |
url |
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/897 |
identifier_str_mv |
10.32712/2446-4775.2021.897 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/897/767 https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/897/768 https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/897/821 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Revista Fitos https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Revista Fitos https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/html text/html |
dc.publisher.none.fl_str_mv |
Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz |
publisher.none.fl_str_mv |
Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz |
dc.source.none.fl_str_mv |
Revista Fitos; Vol. 15 No. 1 (2021); 11-21 Revista Fitos; Vol. 15 Núm. 1 (2021); 11-21 Revista Fitos; v. 15 n. 1 (2021); 11-21 2446-4775 1808-9569 reponame:Revista Fitos instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Revista Fitos |
collection |
Revista Fitos |
repository.name.fl_str_mv |
Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br |
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1798313475073638400 |