Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults

Detalhes bibliográficos
Autor(a) principal: Moraes, Roger de
Data de Publicação: 2014
Outros Autores: Van Bavel, Diogo, Moraes, Beatriz Serpa de, Tibiriça, Eduardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10608
Resumo: Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil / Universidade Estácio de Sá. Escola de Educação Física e Ciências do Esporte. Rio de Janeiro, RJ, Brasil.
id CRUZ_44aad67ad6c399fc8cb3068b0094e3b6
oai_identifier_str oai:www.arca.fiocruz.br:icict/10608
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Moraes, Roger deVan Bavel, DiogoMoraes, Beatriz Serpa deTibiriça, Eduardo2015-06-01T19:34:22Z2015-06-01T19:34:22Z2014MORAES, Roger de et al. Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults. Nutrition Journal, v.13:115, 10p, 2014.1475-2891https://www.arca.fiocruz.br/handle/icict/1060810.1186/1475-2891-13-115engBioMed CentralEffects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adultsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMinistério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil / Universidade Estácio de Sá. Escola de Educação Física e Ciências do Esporte. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Background: Dietary creatine supplementation (CrS) is a practice commonly adopted by physically active individuals. However, the effects of CrS on systemic microvascular reactivity and density have never been reported. Additionally, CrS is able to influence blood levels of homocysteine, resulting in presumed effects on vascular endothelial function. Thus, we investigated the effects of CrS on the systemic microcirculation and on homocysteine levels in healthy young individuals. Methods: This open-label study was performed on a group of 40 healthy male, moderately physically active subjects aged 27.7 ± 13.4 years who received one week of CrS at a dose of 20 g/day of commercially available micronized creatine monohydrate. Laser speckle contrast imaging was used in the evaluation of cutaneous microvascular reactivity, and intra-vital video microscopy was used to evaluate skin capillary density and reactivity, before and after CrS. Results: CrS did not alter plasma levels of homocysteine, although CrS increased creatinine (p = 0.0001) and decreased uric acid (p = 0.0004) plasma levels. Significant changes in total cholesterol (p = 0.0486) and LDL-cholesterol (p = 0.0027) were also observed along with a reduction in plasma levels of T3 (p=0.0074) and an increase in T4 levels (p = 0.0003). Skin functional capillary density (p = 0.0496) and capillary recruitment during post-occlusive reactive hyperemia (p = 0.0043) increased after CrS. Increases in cutaneous microvascular vasodilation induced by post-occlusive reactive hyperemia (p = 0.0078) were also observed. Conclusions: Oral supplementation with creatine in healthy, moderately physically active young adults improves systemic endothelial-dependent microvascular reactivity and increases skin capillary density and recruitment. These effects are not concurrent with changes in plasma homocysteine levels.Laser speckle contrast imagingIntra-vital video-microscopyCapillary recruitmentPost-occlusive reactive hyperemiaCreatinaSaúde do Adultoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10608/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALbeatriz_moraesetal_IOC_2014.pdfapplication/pdf274171https://www.arca.fiocruz.br/bitstream/icict/10608/2/beatriz_moraesetal_IOC_2014.pdf6447e6492ddd4d8cbcee3ef718935753MD52TEXTbeatriz_moraesetal_IOC_2014.pdf.txtbeatriz_moraesetal_IOC_2014.pdf.txtExtracted texttext/plain53122https://www.arca.fiocruz.br/bitstream/icict/10608/3/beatriz_moraesetal_IOC_2014.pdf.txt7a5cd95f83e13730e807a00aea0e835dMD53icict/106082022-06-24 13:08:48.178oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:48Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults
title Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults
spellingShingle Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults
Moraes, Roger de
Laser speckle contrast imaging
Intra-vital video-microscopy
Capillary recruitment
Post-occlusive reactive hyperemia
Creatina
Saúde do Adulto
title_short Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults
title_full Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults
title_fullStr Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults
title_full_unstemmed Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults
title_sort Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults
author Moraes, Roger de
author_facet Moraes, Roger de
Van Bavel, Diogo
Moraes, Beatriz Serpa de
Tibiriça, Eduardo
author_role author
author2 Van Bavel, Diogo
Moraes, Beatriz Serpa de
Tibiriça, Eduardo
author2_role author
author
author
dc.contributor.author.fl_str_mv Moraes, Roger de
Van Bavel, Diogo
Moraes, Beatriz Serpa de
Tibiriça, Eduardo
dc.subject.en.pt_BR.fl_str_mv Laser speckle contrast imaging
Intra-vital video-microscopy
Capillary recruitment
Post-occlusive reactive hyperemia
topic Laser speckle contrast imaging
Intra-vital video-microscopy
Capillary recruitment
Post-occlusive reactive hyperemia
Creatina
Saúde do Adulto
dc.subject.decs.pt_BR.fl_str_mv Creatina
Saúde do Adulto
description Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil / Universidade Estácio de Sá. Escola de Educação Física e Ciências do Esporte. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-06-01T19:34:22Z
dc.date.available.fl_str_mv 2015-06-01T19:34:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MORAES, Roger de et al. Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults. Nutrition Journal, v.13:115, 10p, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10608
dc.identifier.issn.pt_BR.fl_str_mv 1475-2891
dc.identifier.doi.pt_BR.fl_str_mv 10.1186/1475-2891-13-115
identifier_str_mv MORAES, Roger de et al. Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults. Nutrition Journal, v.13:115, 10p, 2014.
1475-2891
10.1186/1475-2891-13-115
url https://www.arca.fiocruz.br/handle/icict/10608
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/10608/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/10608/2/beatriz_moraesetal_IOC_2014.pdf
https://www.arca.fiocruz.br/bitstream/icict/10608/3/beatriz_moraesetal_IOC_2014.pdf.txt
bitstream.checksum.fl_str_mv 7d48279ffeed55da8dfe2f8e81f3b81f
6447e6492ddd4d8cbcee3ef718935753
7a5cd95f83e13730e807a00aea0e835d
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324774102892544

Registros relacionados