Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10608 |
Resumo: | Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil / Universidade Estácio de Sá. Escola de Educação Física e Ciências do Esporte. Rio de Janeiro, RJ, Brasil. |
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Moraes, Roger deVan Bavel, DiogoMoraes, Beatriz Serpa deTibiriça, Eduardo2015-06-01T19:34:22Z2015-06-01T19:34:22Z2014MORAES, Roger de et al. Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults. Nutrition Journal, v.13:115, 10p, 2014.1475-2891https://www.arca.fiocruz.br/handle/icict/1060810.1186/1475-2891-13-115engBioMed CentralEffects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adultsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMinistério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil / Universidade Estácio de Sá. Escola de Educação Física e Ciências do Esporte. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Background: Dietary creatine supplementation (CrS) is a practice commonly adopted by physically active individuals. However, the effects of CrS on systemic microvascular reactivity and density have never been reported. Additionally, CrS is able to influence blood levels of homocysteine, resulting in presumed effects on vascular endothelial function. Thus, we investigated the effects of CrS on the systemic microcirculation and on homocysteine levels in healthy young individuals. Methods: This open-label study was performed on a group of 40 healthy male, moderately physically active subjects aged 27.7 ± 13.4 years who received one week of CrS at a dose of 20 g/day of commercially available micronized creatine monohydrate. Laser speckle contrast imaging was used in the evaluation of cutaneous microvascular reactivity, and intra-vital video microscopy was used to evaluate skin capillary density and reactivity, before and after CrS. Results: CrS did not alter plasma levels of homocysteine, although CrS increased creatinine (p = 0.0001) and decreased uric acid (p = 0.0004) plasma levels. Significant changes in total cholesterol (p = 0.0486) and LDL-cholesterol (p = 0.0027) were also observed along with a reduction in plasma levels of T3 (p=0.0074) and an increase in T4 levels (p = 0.0003). Skin functional capillary density (p = 0.0496) and capillary recruitment during post-occlusive reactive hyperemia (p = 0.0043) increased after CrS. Increases in cutaneous microvascular vasodilation induced by post-occlusive reactive hyperemia (p = 0.0078) were also observed. Conclusions: Oral supplementation with creatine in healthy, moderately physically active young adults improves systemic endothelial-dependent microvascular reactivity and increases skin capillary density and recruitment. These effects are not concurrent with changes in plasma homocysteine levels.Laser speckle contrast imagingIntra-vital video-microscopyCapillary recruitmentPost-occlusive reactive hyperemiaCreatinaSaúde do Adultoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10608/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALbeatriz_moraesetal_IOC_2014.pdfapplication/pdf274171https://www.arca.fiocruz.br/bitstream/icict/10608/2/beatriz_moraesetal_IOC_2014.pdf6447e6492ddd4d8cbcee3ef718935753MD52TEXTbeatriz_moraesetal_IOC_2014.pdf.txtbeatriz_moraesetal_IOC_2014.pdf.txtExtracted texttext/plain53122https://www.arca.fiocruz.br/bitstream/icict/10608/3/beatriz_moraesetal_IOC_2014.pdf.txt7a5cd95f83e13730e807a00aea0e835dMD53icict/106082022-06-24 13:08:48.178oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:48Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults |
title |
Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults |
spellingShingle |
Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults Moraes, Roger de Laser speckle contrast imaging Intra-vital video-microscopy Capillary recruitment Post-occlusive reactive hyperemia Creatina Saúde do Adulto |
title_short |
Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults |
title_full |
Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults |
title_fullStr |
Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults |
title_full_unstemmed |
Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults |
title_sort |
Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults |
author |
Moraes, Roger de |
author_facet |
Moraes, Roger de Van Bavel, Diogo Moraes, Beatriz Serpa de Tibiriça, Eduardo |
author_role |
author |
author2 |
Van Bavel, Diogo Moraes, Beatriz Serpa de Tibiriça, Eduardo |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Moraes, Roger de Van Bavel, Diogo Moraes, Beatriz Serpa de Tibiriça, Eduardo |
dc.subject.en.pt_BR.fl_str_mv |
Laser speckle contrast imaging Intra-vital video-microscopy Capillary recruitment Post-occlusive reactive hyperemia |
topic |
Laser speckle contrast imaging Intra-vital video-microscopy Capillary recruitment Post-occlusive reactive hyperemia Creatina Saúde do Adulto |
dc.subject.decs.pt_BR.fl_str_mv |
Creatina Saúde do Adulto |
description |
Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil / Universidade Estácio de Sá. Escola de Educação Física e Ciências do Esporte. Rio de Janeiro, RJ, Brasil. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-06-01T19:34:22Z |
dc.date.available.fl_str_mv |
2015-06-01T19:34:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MORAES, Roger de et al. Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults. Nutrition Journal, v.13:115, 10p, 2014. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/10608 |
dc.identifier.issn.pt_BR.fl_str_mv |
1475-2891 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1186/1475-2891-13-115 |
identifier_str_mv |
MORAES, Roger de et al. Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults. Nutrition Journal, v.13:115, 10p, 2014. 1475-2891 10.1186/1475-2891-13-115 |
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https://www.arca.fiocruz.br/handle/icict/10608 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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BioMed Central |
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BioMed Central |
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