The global spread of 2019-nCoV: a molecular evolutionary analysis

Detalhes bibliográficos
Autor(a) principal: Benvenuto, Domenico
Data de Publicação: 2020
Outros Autores: Giovanetti, Marta, Salemi, Marco, Prosperi, Mattia, Flora, Cecilia de, Alcantara, Luiz Carlos Junior, Angeletti, Silvia, Ciccozzi, Massimo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40158
Resumo: Devido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação.
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spelling Benvenuto, DomenicoGiovanetti, MartaSalemi, MarcoProsperi, MattiaFlora, Cecilia deAlcantara, Luiz Carlos JuniorAngeletti, SilviaCiccozzi, Massimo2020-02-29T00:40:26Z2020-02-29T00:40:26Z2020BENVENUTO, Domenico et al. The global spread of 2019-nCoV: a molecular evolutionary analysis. Pathogens and Global Health, p. 1-5, Feb. 2020.2047-7724https://www.arca.fiocruz.br/handle/icict/4015810.1080/20477724.2020.17253392047-7732Devido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação.Em decorrência da pandemia decretada pela OMS em 2020, o artigo encontra-se em acesso aberto.University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.University of Florida. Department of Epidemiology. Gainesville, FL, USA / University of Florida. Emerging Pathogens Institute. Gainesville, FL, USA.University of Florida. Department of Epidemiology. Gainesville, FL, USA / University of Florida. Emerging Pathogens Institute. Gainesville, FL, USA.University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.University Campus Bio-Medico of Rome. Unit of Clinical Laboratory Science. Rome, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.The global spread of the 2019-nCoV is continuing and is fast moving, as indicated by the WHO raising the risk assessment to high. In this article, we provide a preliminary phylodynamic and phylogeographic analysis of this new virus. A Maximum Clade Credibility tree has been built using the 29 available whole genome sequences of 2019-nCoV and two whole genome sequences that are highly similar sequences from Bat SARS-like Coronavirus available in GeneBank. We are able to clarify the mechanism of transmission among the countries which have provided the 2019-nCoV sequence isolates from their patients. The Bayesian phylogeographic reconstruction shows that the 2019-2020 nCoV most probably originated from the Bat SARS-like Coronavirus circulating in the Rhinolophus bat family. In agreement with epidemiological observations, the most likely geographic origin of the new outbreak was the city of Wuhan, China, where 2019-nCoV time of the most recent common ancestor emerged, according to molecular clock analysis, around November 25th, 2019. These results, together with previously recorded epidemics, suggest a recurring pattern of periodical epizootic outbreaks due to Betacoronavirus. Moreover, our study describes the same population genetic dynamic underlying the SARS 2003 epidemic, and suggests the urgent need for the development of effective molecular surveillance strategies of Betacoronavirus among animals and Rhinolophus of the bat family.engTaylor & FrancisCOVID-192019-nCoVEpidemiologia molecularFilogeniaSARSCoronavírus2019-nCoVMolecular epidemiologyPhylogenySARSCOVID-19The global spread of 2019-nCoV: a molecular evolutionary analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv The global spread of 2019-nCoV: a molecular evolutionary analysis
title The global spread of 2019-nCoV: a molecular evolutionary analysis
spellingShingle The global spread of 2019-nCoV: a molecular evolutionary analysis
Benvenuto, Domenico
COVID-19
2019-nCoV
Epidemiologia molecular
Filogenia
SARS
Coronavírus
2019-nCoV
Molecular epidemiology
Phylogeny
SARS
COVID-19
title_short The global spread of 2019-nCoV: a molecular evolutionary analysis
title_full The global spread of 2019-nCoV: a molecular evolutionary analysis
title_fullStr The global spread of 2019-nCoV: a molecular evolutionary analysis
title_full_unstemmed The global spread of 2019-nCoV: a molecular evolutionary analysis
title_sort The global spread of 2019-nCoV: a molecular evolutionary analysis
author Benvenuto, Domenico
author_facet Benvenuto, Domenico
Giovanetti, Marta
Salemi, Marco
Prosperi, Mattia
Flora, Cecilia de
Alcantara, Luiz Carlos Junior
Angeletti, Silvia
Ciccozzi, Massimo
author_role author
author2 Giovanetti, Marta
Salemi, Marco
Prosperi, Mattia
Flora, Cecilia de
Alcantara, Luiz Carlos Junior
Angeletti, Silvia
Ciccozzi, Massimo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Benvenuto, Domenico
Giovanetti, Marta
Salemi, Marco
Prosperi, Mattia
Flora, Cecilia de
Alcantara, Luiz Carlos Junior
Angeletti, Silvia
Ciccozzi, Massimo
dc.subject.other.none.fl_str_mv COVID-19
topic COVID-19
2019-nCoV
Epidemiologia molecular
Filogenia
SARS
Coronavírus
2019-nCoV
Molecular epidemiology
Phylogeny
SARS
COVID-19
dc.subject.other.pt_BR.fl_str_mv 2019-nCoV
Epidemiologia molecular
Filogenia
SARS
Coronavírus
dc.subject.en.pt_BR.fl_str_mv 2019-nCoV
Molecular epidemiology
Phylogeny
SARS
COVID-19
description Devido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-02-29T00:40:26Z
dc.date.available.fl_str_mv 2020-02-29T00:40:26Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BENVENUTO, Domenico et al. The global spread of 2019-nCoV: a molecular evolutionary analysis. Pathogens and Global Health, p. 1-5, Feb. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40158
dc.identifier.issn.pt_BR.fl_str_mv 2047-7724
dc.identifier.doi.none.fl_str_mv 10.1080/20477724.2020.1725339
dc.identifier.eissn.none.fl_str_mv 2047-7732
identifier_str_mv BENVENUTO, Domenico et al. The global spread of 2019-nCoV: a molecular evolutionary analysis. Pathogens and Global Health, p. 1-5, Feb. 2020.
2047-7724
10.1080/20477724.2020.1725339
2047-7732
url https://www.arca.fiocruz.br/handle/icict/40158
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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