The 2019-new coronavirus epidemic: evidence for virus evolution

Detalhes bibliográficos
Autor(a) principal: Benvenuto, Domenico
Data de Publicação: 2020
Outros Autores: Giovanetti, Marta, Ciccozzi, Alessandra, Spoto, Silvia, Angeletti, Silvia, Ciccozzi, Massimo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40022
Resumo: University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.
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spelling Benvenuto, DomenicoGiovanetti, MartaCiccozzi, AlessandraSpoto, SilviaAngeletti, SilviaCiccozzi, Massimo2020-02-17T19:14:42Z2020-02-17T19:14:42Z2020BENVENUTO, Domenico et al. The 2019-new coronavirus epidemic: evidence for virus evolution. p. 1-12. 2020.https://www.arca.fiocruz.br/handle/icict/4002210.1101/2020.01.24.915157engWileyhttps://www.arca.fiocruz.br/handle/icict/400202019-nCoVEpidemiologia molecularSARSFilogenia2019-nCoVMolecular epidemiologyPhylogenySARSCOVID-19The 2019-new coronavirus epidemic: evidence for virus evolutioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.University Campus Bio-Medico of Rome. Internal Medicine Unit. Rome, Italy.University Campus Bio-Medico of Rome. Unit of Clinical Laboratory Science. Rome, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.There is concern about a new coronavirus, the 2019-nCoV, as a global public health threat. In this article, we provide a preliminary evolutionary and molecular epidemiological analysis of this new virus. A phylogenetic tree has been built using the 15 available whole genome sequence of 2019-nCoV and 12 whole genome sequences highly similar sequences available in gene bank (5 from SARS, 2 from MERS and 5 from Bat SARS-like Coronavirus). FUBAR analysis shows that the Nucleocapsid and the Spike Glycoprotein has some sites under positive pressure while homology modelling helped to explain some molecular and structural differences between the viruses. The phylogenetic tree showed that 2019.nCoV significantly clustered with Bat SARS-like Coronavirus sequence isolated in 2015, whereas structural analysis revealed mutation in S and nucleocapsid proteins. From these results, 2019nCoV could be considered a coronavirus distinct from SARS virus, probably transmitted from bats or another host where mutations conferred upon it the ability to infect humans.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40022/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMassimoCiccozzi_MartaGiovanetti_etal_IOC_2020.pdfMassimoCiccozzi_MartaGiovanetti_etal_IOC_2020.pdfapplication/pdf307537https://www.arca.fiocruz.br/bitstream/icict/40022/2/MassimoCiccozzi_MartaGiovanetti_etal_IOC_2020.pdfba1417c93df405339a564026a868c059MD52TEXTMassimoCiccozzi_MartaGiovanetti_etal_IOC_2020.pdf.txtMassimoCiccozzi_MartaGiovanetti_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The 2019-new coronavirus epidemic: evidence for virus evolution
title The 2019-new coronavirus epidemic: evidence for virus evolution
spellingShingle The 2019-new coronavirus epidemic: evidence for virus evolution
Benvenuto, Domenico
2019-nCoV
Epidemiologia molecular
SARS
Filogenia
2019-nCoV
Molecular epidemiology
Phylogeny
SARS
COVID-19
title_short The 2019-new coronavirus epidemic: evidence for virus evolution
title_full The 2019-new coronavirus epidemic: evidence for virus evolution
title_fullStr The 2019-new coronavirus epidemic: evidence for virus evolution
title_full_unstemmed The 2019-new coronavirus epidemic: evidence for virus evolution
title_sort The 2019-new coronavirus epidemic: evidence for virus evolution
author Benvenuto, Domenico
author_facet Benvenuto, Domenico
Giovanetti, Marta
Ciccozzi, Alessandra
Spoto, Silvia
Angeletti, Silvia
Ciccozzi, Massimo
author_role author
author2 Giovanetti, Marta
Ciccozzi, Alessandra
Spoto, Silvia
Angeletti, Silvia
Ciccozzi, Massimo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Benvenuto, Domenico
Giovanetti, Marta
Ciccozzi, Alessandra
Spoto, Silvia
Angeletti, Silvia
Ciccozzi, Massimo
dc.subject.other.pt_BR.fl_str_mv 2019-nCoV
Epidemiologia molecular
SARS
Filogenia
topic 2019-nCoV
Epidemiologia molecular
SARS
Filogenia
2019-nCoV
Molecular epidemiology
Phylogeny
SARS
COVID-19
dc.subject.en.pt_BR.fl_str_mv 2019-nCoV
Molecular epidemiology
Phylogeny
SARS
COVID-19
description University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-02-17T19:14:42Z
dc.date.available.fl_str_mv 2020-02-17T19:14:42Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BENVENUTO, Domenico et al. The 2019-new coronavirus epidemic: evidence for virus evolution. p. 1-12. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40022
dc.identifier.doi.pt_BR.fl_str_mv 10.1101/2020.01.24.915157
identifier_str_mv BENVENUTO, Domenico et al. The 2019-new coronavirus epidemic: evidence for virus evolution. p. 1-12. 2020.
10.1101/2020.01.24.915157
url https://www.arca.fiocruz.br/handle/icict/40022
dc.language.iso.fl_str_mv eng
language eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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