Assessment of the Accuracy, Usability and Acceptability of a Rapid Test for the Simultaneous Diagnosis of Syphilis and HIV Infection in a Real-Life Scenario in the Amazon Region, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.3390/diagnostics13040810 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58038 |
Resumo: | Evandro Chagas Institute. Bacteriology and Mycology Section. Laboratory of Sexually Transmitted Infections. Ananindeua, PA, Brazil. |
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Soares, Daniela CristinaFranco Filho, Luciano ChavesReis, Herald Souza dosRodrigues, Yan CorrêaFreitas, Felipe BonfimSouza, Cintya de OliveiraDamacena, Giseli NogueiraVéras, Nazle Mendonça CollaçoGaspar, Pamela CristinaBenzaken, Adele SchwartzFavacho, Joana da Felicidade RibeiroMacedo, Olinda2023-04-27T16:36:23Z2023-04-27T16:36:23Z2023SOARES, Daniela Cristina et al. Assessment of the accuracy, usability and acceptability of a rapid test for the simultaneous diagnosis of syphilis and HIV infection in a real-life scenario in the Amazon Region, Brazil. Diagnostics, v. 13, n. 4, p. 1-11, Feb. 2023.2075-4418https://www.arca.fiocruz.br/handle/icict/5803810.3390/diagnostics13040810engMDPIAssessment of the Accuracy, Usability and Acceptability of a Rapid Test for the Simultaneous Diagnosis of Syphilis and HIV Infection in a Real-Life Scenario in the Amazon Region, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEvandro Chagas Institute. Bacteriology and Mycology Section. Laboratory of Sexually Transmitted Infections. Ananindeua, PA, Brazil.Evandro Chagas Institute. Bacteriology and Mycology Section. Laboratory of Sexually Transmitted Infections. Ananindeua, PA, Brazil.Evandro Chagas Institute. Bacteriology and Mycology Section. Laboratory of Sexually Transmitted Infections. Ananindeua, PA, Brazil.Evandro Chagas Institute. Bacteriology and Mycology Section. Laboratory of Sexually Transmitted Infections. Ananindeua, PA, Brazil.Evandro Chagas Institute. Virology Section. Retrovirus Laboratory. Ananindeua. PA, Brazil.Evandro Chagas Institute. Bacteriology and Mycology Section. Laboratory of Sexually Transmitted Infections. Ananindeua, PA, Brazil.Oswaldo Cruz Foundation. Institute of Scientific and Technological Communication and Information in Health. Rio de Janeiro, RJ, Brazil.Ministry of Health. Department of Diseases of Chronic Condition and Sexually Transmitted Infections. Brasília, DF, Brazil.Ministry of Health. Department of Diseases of Chronic Condition and Sexually Transmitted Infections. Brasília, DF, Brazil.Oswaldo Cruz Foundation. Institute of Maria Leônidas e Maria Deane. Manaus, AM, Brazil / AIDS Healthcare Foudation. Los Angeles, CA, United States.Evandro Chagas Institute. Bacteriology and Mycology Section. Laboratory of Sexually Transmitted Infections. Ananindeua, PA, Brazil.Evandro Chagas Institute. Virology Section. Retrovirus Laboratory. Ananindeua. PA, Brazil.Federal University of Santa Catarina. Center for Health Sciences. Graduate Program in Pharmacy. Florianópolis, SC, Brazil.We field-assessed the accuracy, acceptability, and feasibility of the SD BIOLINE HIV/Syphilis Duo rapid diagnostic test in three groups: pregnant women, female sex workers (FSW), and men who have sex with men (MSM). Venous blood samples collected in the field were compared with the respective gold standard methods: SD BIOLINE HIV/Syphilis Duo Treponemal Test versus FTA-abs (Wama brand) treponemal laboratory test for syphilis, and SD BIOLINE HIV/Syphilis Duo Test versus the fourth generation Genscreen Ultra HIV Ag-Ag (Bio-Rad brand) laboratory test for HIV. From a total of 529 participants, 397 (75.1%) were pregnant women, 76 (14.3%) FSW and 56 (10.6%) MSM. Sensitivity and specificity parameters of HIV were 100.0% (95% CI: 82.35–100.0%) and 100.0% (95% CI: 99.28–100.0%), respectively. Sensitivity and specificity parameters found for TP antibody detection were 95.00% (95% CI: 87.69–98.62%) and 100.0% (95% CI: 98.18–100.0%), respectively. The SD BIOLINE HIV/Syphilis Duo Test showed high acceptability among participants (85.87%) and health professionals (85.51%), as well as easy usability by professionals (91.06%). The usability of the SD BIOLINE HIV/Syphilis Duo Test kit would not be a barrier to accessing rapid testing, if the product were incorporated into the list of health service supplies.AmazonDiagnosisDuo testHIVKappa coefficientScreeningSD bioline duo assaySensitivitySpecificitySyphilisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58038/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALdiagnostics-13-00810-v2.pdfdiagnostics-13-00810-v2.pdfArtigoapplication/pdf681502https://www.arca.fiocruz.br/bitstream/icict/58038/2/diagnostics-13-00810-v2.pdfa433575cfbc8a524ee9de1867671f825MD52icict/580382023-10-27 14:18:54.615oai:www.arca.fiocruz.br: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ório 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| dc.title.en_US.fl_str_mv |
Assessment of the Accuracy, Usability and Acceptability of a Rapid Test for the Simultaneous Diagnosis of Syphilis and HIV Infection in a Real-Life Scenario in the Amazon Region, Brazil |
| title |
Assessment of the Accuracy, Usability and Acceptability of a Rapid Test for the Simultaneous Diagnosis of Syphilis and HIV Infection in a Real-Life Scenario in the Amazon Region, Brazil |
| spellingShingle |
Assessment of the Accuracy, Usability and Acceptability of a Rapid Test for the Simultaneous Diagnosis of Syphilis and HIV Infection in a Real-Life Scenario in the Amazon Region, Brazil Soares, Daniela Cristina Amazon Diagnosis Duo test HIV Kappa coefficient Screening SD bioline duo assay Sensitivity Specificity Syphilis |
| title_short |
Assessment of the Accuracy, Usability and Acceptability of a Rapid Test for the Simultaneous Diagnosis of Syphilis and HIV Infection in a Real-Life Scenario in the Amazon Region, Brazil |
| title_full |
Assessment of the Accuracy, Usability and Acceptability of a Rapid Test for the Simultaneous Diagnosis of Syphilis and HIV Infection in a Real-Life Scenario in the Amazon Region, Brazil |
| title_fullStr |
Assessment of the Accuracy, Usability and Acceptability of a Rapid Test for the Simultaneous Diagnosis of Syphilis and HIV Infection in a Real-Life Scenario in the Amazon Region, Brazil |
| title_full_unstemmed |
Assessment of the Accuracy, Usability and Acceptability of a Rapid Test for the Simultaneous Diagnosis of Syphilis and HIV Infection in a Real-Life Scenario in the Amazon Region, Brazil |
| title_sort |
Assessment of the Accuracy, Usability and Acceptability of a Rapid Test for the Simultaneous Diagnosis of Syphilis and HIV Infection in a Real-Life Scenario in the Amazon Region, Brazil |
| author |
Soares, Daniela Cristina |
| author_facet |
Soares, Daniela Cristina Franco Filho, Luciano Chaves Reis, Herald Souza dos Rodrigues, Yan Corrêa Freitas, Felipe Bonfim Souza, Cintya de Oliveira Damacena, Giseli Nogueira Véras, Nazle Mendonça Collaço Gaspar, Pamela Cristina Benzaken, Adele Schwartz Favacho, Joana da Felicidade Ribeiro Macedo, Olinda |
| author_role |
author |
| author2 |
Franco Filho, Luciano Chaves Reis, Herald Souza dos Rodrigues, Yan Corrêa Freitas, Felipe Bonfim Souza, Cintya de Oliveira Damacena, Giseli Nogueira Véras, Nazle Mendonça Collaço Gaspar, Pamela Cristina Benzaken, Adele Schwartz Favacho, Joana da Felicidade Ribeiro Macedo, Olinda |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Soares, Daniela Cristina Franco Filho, Luciano Chaves Reis, Herald Souza dos Rodrigues, Yan Corrêa Freitas, Felipe Bonfim Souza, Cintya de Oliveira Damacena, Giseli Nogueira Véras, Nazle Mendonça Collaço Gaspar, Pamela Cristina Benzaken, Adele Schwartz Favacho, Joana da Felicidade Ribeiro Macedo, Olinda |
| dc.subject.en.en_US.fl_str_mv |
Amazon Diagnosis Duo test HIV Kappa coefficient Screening SD bioline duo assay Sensitivity Specificity Syphilis |
| topic |
Amazon Diagnosis Duo test HIV Kappa coefficient Screening SD bioline duo assay Sensitivity Specificity Syphilis |
| description |
Evandro Chagas Institute. Bacteriology and Mycology Section. Laboratory of Sexually Transmitted Infections. Ananindeua, PA, Brazil. |
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2023 |
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2023-04-27T16:36:23Z |
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2023-04-27T16:36:23Z |
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2023 |
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info:eu-repo/semantics/article |
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article |
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SOARES, Daniela Cristina et al. Assessment of the accuracy, usability and acceptability of a rapid test for the simultaneous diagnosis of syphilis and HIV infection in a real-life scenario in the Amazon Region, Brazil. Diagnostics, v. 13, n. 4, p. 1-11, Feb. 2023. |
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https://www.arca.fiocruz.br/handle/icict/58038 |
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2075-4418 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/diagnostics13040810 |
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SOARES, Daniela Cristina et al. Assessment of the accuracy, usability and acceptability of a rapid test for the simultaneous diagnosis of syphilis and HIV infection in a real-life scenario in the Amazon Region, Brazil. Diagnostics, v. 13, n. 4, p. 1-11, Feb. 2023. 2075-4418 10.3390/diagnostics13040810 |
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