Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children

Detalhes bibliográficos
Autor(a) principal: Vaz, Sara Nunes
Data de Publicação: 2015
Outros Autores: Giovanetti, Marta, Rego, Filipe Ferreira de Almeida, Oliveira, Tulio de, Danaviah, Siva, Gonçalves, Maria Luiza Freire, Alcantara, Luiz Carlos Júnior, Brites, Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13738
Resumo: Universidade Federal da Bahia. Laboratório de Retrovirologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil
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spelling Vaz, Sara NunesGiovanetti, MartaRego, Filipe Ferreira de AlmeidaOliveira, Tulio deDanaviah, SivaGonçalves, Maria Luiza FreireAlcantara, Luiz Carlos JúniorBrites, Carlos2016-04-12T19:09:05Z2016-04-12T19:09:05Z2015VAZ, S. N. et al. Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children. AIDS Research Human Retroviruses, v. 31, n. 10, p. 1046-1051, 2015.1931-8405https://www.arca.fiocruz.br/handle/icict/1373810.1089/aid.2015.0166engMary Ann LiebertHIV-1VirusTransmissãoInfecçãoMutaçõesFemininoCriançasMolecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Laboratório de Retrovirologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil / National Institute of Health. Department of Infectious, Parasitic and Immunomediated Diseases. Rome, ItalyFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, BrasilUniversity of KwaZulu-Natal. Africa Centre for Health and Population Studies. Durban, South AfricaUniversity of KwaZulu-Natal. Africa Centre for Health and Population Studies. Durban, South AfricaSpecialized Center in Diagnosis. Care and Research. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, BrasilUniversidade Federal da Bahia. Laboratório de Retrovirologia. Salvador, BA, BrasilApproximately 35 million people worldwide are infected with human immunodeficiency virus (HIV) around 3.2 million of whom are children under 15 years. Mother-to-child-transmission (MTCT) of HIV-1 accounts for 90% of all infections in children. Despite great advances in the prevention of MTCT in Brazil, children are still becoming infected. Samples from 19 HIV-1-infected families were collected. DNA was extracted and fragments from gag, pol, and env were amplified and sequenced directly. Phylogenetic reconstruction was performed. Drug resistance analyses were performed in pol and env sequences. We found 82.1% of subtype B and 17.9% of BF recombinants. A prevalence of 43.9% drug resistance-associated mutations in pol sequences was identified. Of the drug-naive children 33.3% presented at least one mutation related to protease inhibitor/nucleoside reverse transcriptase inhibitor/nonnucleoside reverse transcriptase inhibitor (PI/NRTI/NNRTI) resistance. The prevalence of transmitted drug resistance mutations was 4.9%. On env we found a low prevalence of HR1 (4.9%) and HR2 (14.6%) mutationsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13738/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVaz, SN Moleclar characterization....pdfVaz, SN Moleclar characterization....pdfapplication/pdf262672https://www.arca.fiocruz.br/bitstream/icict/13738/2/Vaz%2c%20SN%20Moleclar%20characterization....pdf436a162d92bca9f20ec5bae7e24f9bebMD52TEXTVaz, SN Moleclar characterization....pdf.txtVaz, SN Moleclar characterization....pdf.txtExtracted texttext/plain21582https://www.arca.fiocruz.br/bitstream/icict/13738/3/Vaz%2c%20SN%20Moleclar%20characterization....pdf.txt3f7b2ad26275cbc206422127097179b6MD53icict/137382023-03-15 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dc.title.pt_BR.fl_str_mv Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children
title Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children
spellingShingle Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children
Vaz, Sara Nunes
HIV-1
Virus
Transmissão
Infecção
Mutações
Feminino
Crianças
title_short Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children
title_full Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children
title_fullStr Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children
title_full_unstemmed Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children
title_sort Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children
author Vaz, Sara Nunes
author_facet Vaz, Sara Nunes
Giovanetti, Marta
Rego, Filipe Ferreira de Almeida
Oliveira, Tulio de
Danaviah, Siva
Gonçalves, Maria Luiza Freire
Alcantara, Luiz Carlos Júnior
Brites, Carlos
author_role author
author2 Giovanetti, Marta
Rego, Filipe Ferreira de Almeida
Oliveira, Tulio de
Danaviah, Siva
Gonçalves, Maria Luiza Freire
Alcantara, Luiz Carlos Júnior
Brites, Carlos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vaz, Sara Nunes
Giovanetti, Marta
Rego, Filipe Ferreira de Almeida
Oliveira, Tulio de
Danaviah, Siva
Gonçalves, Maria Luiza Freire
Alcantara, Luiz Carlos Júnior
Brites, Carlos
dc.subject.other.pt_BR.fl_str_mv HIV-1
Virus
Transmissão
Infecção
Mutações
Feminino
Crianças
topic HIV-1
Virus
Transmissão
Infecção
Mutações
Feminino
Crianças
description Universidade Federal da Bahia. Laboratório de Retrovirologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-12T19:09:05Z
dc.date.available.fl_str_mv 2016-04-12T19:09:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VAZ, S. N. et al. Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children. AIDS Research Human Retroviruses, v. 31, n. 10, p. 1046-1051, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13738
dc.identifier.issn.none.fl_str_mv 1931-8405
dc.identifier.doi.none.fl_str_mv 10.1089/aid.2015.0166
identifier_str_mv VAZ, S. N. et al. Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children. AIDS Research Human Retroviruses, v. 31, n. 10, p. 1046-1051, 2015.
1931-8405
10.1089/aid.2015.0166
url https://www.arca.fiocruz.br/handle/icict/13738
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/13738/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/13738/2/Vaz%2c%20SN%20Moleclar%20characterization....pdf
https://www.arca.fiocruz.br/bitstream/icict/13738/3/Vaz%2c%20SN%20Moleclar%20characterization....pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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