24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of cases

Detalhes bibliográficos
Autor(a) principal: Orofino, Dulce Helena Gonçalves
Data de Publicação: 2020
Outros Autores: Passos, Sonia Regina Lambert, Pone, Sheila Moura, Pone, Marcos Vinícius da Silva, Aguiar, Elisa Barroso de, Araújo, Igo Oliveira de, Ramos, Thiago Moreira, Silva, Letícia Machado Lima E, Oliveira, Bruna Menezes de, Silva, Luan Noé da, Goldenzon, Rafaela Valentim, Moreira, Maria Elisabeth Lopes, Oliveira, Raquel de Vasconcellos Carvalhaes de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42314
Resumo: SRLP was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), grants Nº 440846/2016-1 and 310765/2016-1, by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), grant Nº 88881130793/2016-01, and by Universidade Estácio de Sá - Produtividade em Pesquisa . LMLS was supported by CAPES grant Nº 88887.162025/2017-00. RVG and TMR had a scholarship ITI-A from CNPq.
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spelling Orofino, Dulce Helena GonçalvesPassos, Sonia Regina LambertPone, Sheila MouraPone, Marcos Vinícius da SilvaAguiar, Elisa Barroso deAraújo, Igo Oliveira deRamos, Thiago MoreiraSilva, Letícia Machado Lima EOliveira, Bruna Menezes deSilva, Luan Noé daGoldenzon, Rafaela ValentimMoreira, Maria Elisabeth LopesOliveira, Raquel de Vasconcellos Carvalhaes de2020-07-20T20:16:01Z2020-07-20T20:16:01Z2020OROFINO, Dulce Helena Gonçalves et al . 24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of cases. Rev. Inst. Med. trop. S. Paulo, São Paulo , v. 62, e50, 2020 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652020000100606&lng=en&nrm=iso>. access on 20 July 2020. Epub July 13, 2020. https://doi.org/10.1590/s1678-9946202062050.1678-9946https://www.arca.fiocruz.br/handle/icict/4231410.1590/s1678-9946202062050SRLP was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), grants Nº 440846/2016-1 and 310765/2016-1, by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), grant Nº 88881130793/2016-01, and by Universidade Estácio de Sá - Produtividade em Pesquisa . LMLS was supported by CAPES grant Nº 88887.162025/2017-00. RVG and TMR had a scholarship ITI-A from CNPq.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia Clínica. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia Clínica. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Departmento de Doenças Infecciosas.Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Departmento de Doenças Infecciosas.Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Departmento de Doenças Infecciosas.Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Departmento de Doenças Infecciosas.Rio de Janeiro, RJ. Brasil.Universidade Estácio de Sá, Rio de Janeiro, Brasil.Universidade Estácio de Sá, Rio de Janeiro, Brasil.Universidade Estácio de Sá, Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia Clínica. Rio de Janeiro, RJ. Brasil.Escola de Medicina Souza Marques, Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Departamento de Pediatria.Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia Clínica. Rio de Janeiro, RJ. Brasil.Severe neurological problems and other special manifestations such as high prevalence of structural cardiac changes has been described in infants vertically exposed to the Zika virus (ZIKV) and has been called congenital Zika virus syndrome (CZS). Previous studies have shown that the 24-hour Holter heart rate variability (HRV) analysis allows the prediction of worse outcomes in infants with neurological impairment and higher risk of sudden infant death syndrome (SIDS), hypertension, diabetes mellitus and other cardiovascular diseases. This study describes the 24-hour Holter findings of infants with confirmed vertical exposure to the ZIKV by positive polymerase chain reaction (PCR) assays in the mother's blood during pregnancy and/or in the urine or cerebrospinal fluid of the newborn. Data analysis was descriptive and included two subgroups according to the presence of fetal distress, positive PCR to ZIKV in the newborn, CZS and severe microcephaly. Heart rate, pauses, arrhythmias, ST segment and QT interval analyses and HRV evaluation through R-R, SDNN, pNN50 and rMMSD were described. The Mann-Whitney test was performed to assess differences between the two subgroups. The sample consisted of 15 infants with a mean age of 16 months, nine of whom were male. No arrhythmias or QT interval changes were observed. The comparison of HRV through the Mann-Whitney test showed a significant difference between patients with and without CZS, with and without severe microcephaly, with lower HRV in the groups with severe microcephaly and CZS. The study suggests that there is an increased risk of SIDS and cardiovascular diseases in this group of patients.engInstituto de Medicina TropicalZika virusZika VirusZika virusHolterArrhythmiasHeart rate variabilityVertical transmissionCongenital infectionCongenital Zika Virus Syndrome24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of casesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv 24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of cases
title 24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of cases
spellingShingle 24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of cases
Orofino, Dulce Helena Gonçalves
Zika virus
Zika Virus
Zika virus
Holter
Arrhythmias
Heart rate variability
Vertical transmission
Congenital infection
Congenital Zika Virus Syndrome
title_short 24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of cases
title_full 24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of cases
title_fullStr 24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of cases
title_full_unstemmed 24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of cases
title_sort 24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of cases
author Orofino, Dulce Helena Gonçalves
author_facet Orofino, Dulce Helena Gonçalves
Passos, Sonia Regina Lambert
Pone, Sheila Moura
Pone, Marcos Vinícius da Silva
Aguiar, Elisa Barroso de
Araújo, Igo Oliveira de
Ramos, Thiago Moreira
Silva, Letícia Machado Lima E
Oliveira, Bruna Menezes de
Silva, Luan Noé da
Goldenzon, Rafaela Valentim
Moreira, Maria Elisabeth Lopes
Oliveira, Raquel de Vasconcellos Carvalhaes de
author_role author
author2 Passos, Sonia Regina Lambert
Pone, Sheila Moura
Pone, Marcos Vinícius da Silva
Aguiar, Elisa Barroso de
Araújo, Igo Oliveira de
Ramos, Thiago Moreira
Silva, Letícia Machado Lima E
Oliveira, Bruna Menezes de
Silva, Luan Noé da
Goldenzon, Rafaela Valentim
Moreira, Maria Elisabeth Lopes
Oliveira, Raquel de Vasconcellos Carvalhaes de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Orofino, Dulce Helena Gonçalves
Passos, Sonia Regina Lambert
Pone, Sheila Moura
Pone, Marcos Vinícius da Silva
Aguiar, Elisa Barroso de
Araújo, Igo Oliveira de
Ramos, Thiago Moreira
Silva, Letícia Machado Lima E
Oliveira, Bruna Menezes de
Silva, Luan Noé da
Goldenzon, Rafaela Valentim
Moreira, Maria Elisabeth Lopes
Oliveira, Raquel de Vasconcellos Carvalhaes de
dc.subject.mesh.pt_BR.fl_str_mv Zika virus
topic Zika virus
Zika Virus
Zika virus
Holter
Arrhythmias
Heart rate variability
Vertical transmission
Congenital infection
Congenital Zika Virus Syndrome
dc.subject.other.pt_BR.fl_str_mv Zika Virus
dc.subject.en.pt_BR.fl_str_mv Zika virus
Holter
Arrhythmias
Heart rate variability
Vertical transmission
Congenital infection
Congenital Zika Virus Syndrome
description SRLP was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), grants Nº 440846/2016-1 and 310765/2016-1, by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), grant Nº 88881130793/2016-01, and by Universidade Estácio de Sá - Produtividade em Pesquisa . LMLS was supported by CAPES grant Nº 88887.162025/2017-00. RVG and TMR had a scholarship ITI-A from CNPq.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-07-20T20:16:01Z
dc.date.available.fl_str_mv 2020-07-20T20:16:01Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv OROFINO, Dulce Helena Gonçalves et al . 24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of cases. Rev. Inst. Med. trop. S. Paulo, São Paulo , v. 62, e50, 2020 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652020000100606&lng=en&nrm=iso>. access on 20 July 2020. Epub July 13, 2020. https://doi.org/10.1590/s1678-9946202062050.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42314
dc.identifier.issn.pt_BR.fl_str_mv 1678-9946
dc.identifier.doi.none.fl_str_mv 10.1590/s1678-9946202062050
identifier_str_mv OROFINO, Dulce Helena Gonçalves et al . 24-hour Holter findings in infants with in-utero exposure to the Zika virus: a series of cases. Rev. Inst. Med. trop. S. Paulo, São Paulo , v. 62, e50, 2020 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652020000100606&lng=en&nrm=iso>. access on 20 July 2020. Epub July 13, 2020. https://doi.org/10.1590/s1678-9946202062050.
1678-9946
10.1590/s1678-9946202062050
url https://www.arca.fiocruz.br/handle/icict/42314
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language eng
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dc.publisher.none.fl_str_mv Instituto de Medicina Tropical
publisher.none.fl_str_mv Instituto de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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