Chemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espada
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23283 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. |
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Ramos, Eduardo H. S.Moraes, Marcílio M.Nerys, Laís L. de A.Nascimento, Silene C.Militão, Gardênia C. G.Figueiredo, Regina C. B. Q. deCâmara, Cláudio A. G. daSilva, Teresinha Gonçalves2017-11-21T13:39:23Z2017-11-21T13:39:23Z2014RAMOS, E. H. S. et al. Chemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espada. BioMed Research International, v. 2014, p. 734946, 2014.2314-6141https://www.arca.fiocruz.br/handle/icict/2328310.1155/2014/734946engLeishmanioseÓleos VoláteisLeishmaniasisOils, VolatileLeishmaniaefeitos de drogasMangiferaquímicaÓleos Voláteisadministração & dosagemCompostos Bicíclicos com PontesquímicaProliferação Celularefeitos de drogasCélulas HT29HumanosLeishmaniosetratamento farmacológicoMonoterpenosquímicaNeoplasiaspatologiaTerpenosisolamento & purificaçãoChemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espadainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.The essential oils from Mangifera indica var. Rosa and Espada latex were obtained by hydrodistillation and analyzed using GC-FID and GC-MS. Twenty-seven components were identified. The main compound in the essential oil from M. indica var. Espada (EOMiE) was terpinolene (73.6%). The essential oil of M. indica var. Rosa (EOMiR) was characterized by high amounts of β-pinene (40.7%) and terpinolene (28.3%). In the test for leishmanicidal activity against promastigotes forms of L. amazonensis, EOMiR and EOMiE showed IC50 (72 h) of 39.1 and 23.0 μg/mL, respectively. In macrophages, EOMiR and EOMiE showed CC50 of 142.84 and 158.65 μg/mL, respectively. However, both were more specific to the parasite than macrophages, with values of selectivity index of 6.91 for EOMiE and 3.66 for EOMiR. The essential oils were evaluated for their cytotoxicity against the human tumor cells HEp-2, HT-29, NCI-H292, and HL-60. The EOMiR and EOMiE were most effective against the HL-60, with IC50 values of 12.3 and 3.6 μg/mL, respectively. The results demonstrated that the essential oils of M. indica can destroy L. amazonensis and inhibit tumor cell growth. These findings contribute to the knowledge of the Brazilian biodiversity as a source of potential therapeutic agents.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/23283/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINALart. Chemical Composition - ramos.pdfart. 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| dc.title.pt_BR.fl_str_mv |
Chemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espada |
| title |
Chemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espada |
| spellingShingle |
Chemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espada Ramos, Eduardo H. S. Leishmaniose Óleos Voláteis Leishmaniasis Oils, Volatile Leishmania efeitos de drogas Mangifera química Óleos Voláteis administração & dosagem Compostos Bicíclicos com Pontes química Proliferação Celular efeitos de drogas Células HT29 Humanos Leishmaniose tratamento farmacológico Monoterpenos química Neoplasias patologia Terpenos isolamento & purificação |
| title_short |
Chemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espada |
| title_full |
Chemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espada |
| title_fullStr |
Chemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espada |
| title_full_unstemmed |
Chemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espada |
| title_sort |
Chemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espada |
| author |
Ramos, Eduardo H. S. |
| author_facet |
Ramos, Eduardo H. S. Moraes, Marcílio M. Nerys, Laís L. de A. Nascimento, Silene C. Militão, Gardênia C. G. Figueiredo, Regina C. B. Q. de Câmara, Cláudio A. G. da Silva, Teresinha Gonçalves |
| author_role |
author |
| author2 |
Moraes, Marcílio M. Nerys, Laís L. de A. Nascimento, Silene C. Militão, Gardênia C. G. Figueiredo, Regina C. B. Q. de Câmara, Cláudio A. G. da Silva, Teresinha Gonçalves |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ramos, Eduardo H. S. Moraes, Marcílio M. Nerys, Laís L. de A. Nascimento, Silene C. Militão, Gardênia C. G. Figueiredo, Regina C. B. Q. de Câmara, Cláudio A. G. da Silva, Teresinha Gonçalves |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose Óleos Voláteis |
| topic |
Leishmaniose Óleos Voláteis Leishmaniasis Oils, Volatile Leishmania efeitos de drogas Mangifera química Óleos Voláteis administração & dosagem Compostos Bicíclicos com Pontes química Proliferação Celular efeitos de drogas Células HT29 Humanos Leishmaniose tratamento farmacológico Monoterpenos química Neoplasias patologia Terpenos isolamento & purificação |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis Oils, Volatile |
| dc.subject.decs.pt_BR.fl_str_mv |
Leishmania efeitos de drogas Mangifera química Óleos Voláteis administração & dosagem Compostos Bicíclicos com Pontes química Proliferação Celular efeitos de drogas Células HT29 Humanos Leishmaniose tratamento farmacológico Monoterpenos química Neoplasias patologia Terpenos isolamento & purificação |
| description |
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. |
| publishDate |
2014 |
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2014 |
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2017-11-21T13:39:23Z |
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2017-11-21T13:39:23Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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RAMOS, E. H. S. et al. Chemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espada. BioMed Research International, v. 2014, p. 734946, 2014. |
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https://www.arca.fiocruz.br/handle/icict/23283 |
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2314-6141 |
| dc.identifier.doi.none.fl_str_mv |
10.1155/2014/734946 |
| identifier_str_mv |
RAMOS, E. H. S. et al. Chemical composition, leishmanicidal and cytotoxic activities of the essential oils from Mangifera indica L. var. Rosa and Espada. BioMed Research International, v. 2014, p. 734946, 2014. 2314-6141 10.1155/2014/734946 |
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