Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall

Detalhes bibliográficos
Autor(a) principal: Fukutani, Eduardo
Data de Publicação: 2018
Outros Autores: Rodrigues, Moreno, Kasprzykowski, José Irahe, Araujo, Cintia Figueiredo de, Paschoal, Alexandre Rossi, Ramos, Pablo Ivan Pereira, Fukutani, Kiyoshi Ferreira, Queiroz, Artur Trancoso Lopo de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27086
Resumo: FAPESB (process no. JCB0004/2013), FAPESP (no.2017/03491-6), CNPq Universal CTI/CNPQ/Universal14/2014 (no. 454505/2014-0).
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spelling Fukutani, EduardoRodrigues, MorenoKasprzykowski, José IraheAraujo, Cintia Figueiredo dePaschoal, Alexandre RossiRamos, Pablo Ivan PereiraFukutani, Kiyoshi FerreiraQueiroz, Artur Trancoso Lopo de2018-06-25T17:27:09Z2018-06-25T17:27:09Z2018FUKUTANI, E. et al. Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall. Memórias do Instituto Oswaldo Cruz, v. 113, n. 6, p. e180053, 2018.0074-0276https://www.arca.fiocruz.br/handle/icict/2708610.1590/0074-02760180053FAPESB (process no. JCB0004/2013), FAPESP (no.2017/03491-6), CNPq Universal CTI/CNPQ/Universal14/2014 (no. 454505/2014-0).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Pós-Graduação em Biotecnologia em Saúde Investigativa. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Tecnológica Federal do Paraná. Cornélio Procópio, PR, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil / Universidade Salvador. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Pós-Graduação em Biotecnologia em Saúde Investigativa. Salvador, BA, BrasilThe mosquito Aedes aegypti is the main vector of several arthropod-borne diseases that have global impacts. In a previous meta-analysis, our group identified a vector gene set containing 110 genes strongly associated with infections of dengue, West Nile and yellow fever viruses. Of these 110 genes, four genes allowed a highly accurate classification of infected status. More recently, a new study of Ae. aegypti infected with Zika virus (ZIKV) was published, providing new data to investigate whether this "infection" gene set is also altered during a ZIKV infection. Our hypothesis is that the infection-associated signature may also serve as a proxy to classify the ZIKV infection in the vector. Raw data associated with the NCBI/BioProject were downloaded and re-analysed. A total of 18 paired-end replicates corresponding to three ZIKV-infected samples and three controls were included in this study. The nMDS technique with a logistic regression was used to obtain the probabilities of belonging to a given class. Thus, to compare both gene sets, we used the area under the curve and performed a comparison using the bootstrap method. Our meta-signature was able to separate the infected mosquitoes from the controls with good predictive power to classify the Zika-infected mosquitoes.engInstituto Oswaldo CruzRNA-seqAssinaturaTranscriptomaZika virusAedes aegyptiRNA-seqSignatureTranscriptomeZika virusAedes aegyptiFollow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wallinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27086/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFukutani E Follow up of a robust meta-signature to identify......pdfFukutani E Follow up of a robust meta-signature to 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dc.title.pt_BR.fl_str_mv Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall
title Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall
spellingShingle Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall
Fukutani, Eduardo
RNA-seq
Assinatura
Transcriptoma
Zika virus
Aedes aegypti
RNA-seq
Signature
Transcriptome
Zika virus
Aedes aegypti
title_short Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall
title_full Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall
title_fullStr Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall
title_full_unstemmed Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall
title_sort Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall
author Fukutani, Eduardo
author_facet Fukutani, Eduardo
Rodrigues, Moreno
Kasprzykowski, José Irahe
Araujo, Cintia Figueiredo de
Paschoal, Alexandre Rossi
Ramos, Pablo Ivan Pereira
Fukutani, Kiyoshi Ferreira
Queiroz, Artur Trancoso Lopo de
author_role author
author2 Rodrigues, Moreno
Kasprzykowski, José Irahe
Araujo, Cintia Figueiredo de
Paschoal, Alexandre Rossi
Ramos, Pablo Ivan Pereira
Fukutani, Kiyoshi Ferreira
Queiroz, Artur Trancoso Lopo de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fukutani, Eduardo
Rodrigues, Moreno
Kasprzykowski, José Irahe
Araujo, Cintia Figueiredo de
Paschoal, Alexandre Rossi
Ramos, Pablo Ivan Pereira
Fukutani, Kiyoshi Ferreira
Queiroz, Artur Trancoso Lopo de
dc.subject.other.pt_BR.fl_str_mv RNA-seq
Assinatura
Transcriptoma
Zika virus
Aedes aegypti
topic RNA-seq
Assinatura
Transcriptoma
Zika virus
Aedes aegypti
RNA-seq
Signature
Transcriptome
Zika virus
Aedes aegypti
dc.subject.en.pt_BR.fl_str_mv RNA-seq
Signature
Transcriptome
Zika virus
Aedes aegypti
description FAPESB (process no. JCB0004/2013), FAPESP (no.2017/03491-6), CNPq Universal CTI/CNPQ/Universal14/2014 (no. 454505/2014-0).
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-06-25T17:27:09Z
dc.date.available.fl_str_mv 2018-06-25T17:27:09Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FUKUTANI, E. et al. Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall. Memórias do Instituto Oswaldo Cruz, v. 113, n. 6, p. e180053, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27086
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760180053
identifier_str_mv FUKUTANI, E. et al. Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall. Memórias do Instituto Oswaldo Cruz, v. 113, n. 6, p. e180053, 2018.
0074-0276
10.1590/0074-02760180053
url https://www.arca.fiocruz.br/handle/icict/27086
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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