Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1371/journal.pone.0203916 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31740 |
Resumo: | Gorgas Memorial Institute for Health Studies. Panama City, Panama / University of Panama. Department of Genetics and Molecular Biology. Panama City, Panama. |
| id |
CRUZ_49c5cb7c2673082a0c777411a27e725a |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/31740 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Mendoza, YaxelisGarcía-Morales, ClaudiaBello, GonzaloGarrido-Rodríguez, DanielaTapia-Trejo, DanielaPascale, Juan MiguelGirón-Callejas, Amalia CarolinaMendizábal-Burastero, RicardoEscobar-Urias, Ingrid YesseniaGarcía-González, Blanca LeticiaNavas-Castillo, Jessenia SabrinaQuintana-Galindo, María CristinaPinzón-Meza, RodolfoMejía-Villatoro, Carlos RodolfoAvila-Ríos, SantiagoReyes-Terán, Gustavo2019-02-19T12:53:21Z2019-02-19T12:53:21Z2018MENDOZA, Yaxelis et al. Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala. PLoS ONE, v. 13, n. 9, p.1-21, Sept. 2018.1932-6203https://www.arca.fiocruz.br/handle/icict/3174010.1371/journal.pone.0203916engPublic Library of ScienceHistória evolutivaDinâmica espaço-temporalSubtipo B do HIV-1EpidemiaGuatemalaHIV-1 subtype BEvolutionary historySpatiotemporal dynamicsGuatemalaEpidemicEvolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemalainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGorgas Memorial Institute for Health Studies. Panama City, Panama / University of Panama. Department of Genetics and Molecular Biology. Panama City, Panama.Centre for Research in Infectious Diseases. National Institute of Respiratory Diseases. Mexico City, Mexico.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Centre for Research in Infectious Diseases. National Institute of Respiratory Diseases. Mexico City, Mexico.Centre for Research in Infectious Diseases. National Institute of Respiratory Diseases. Mexico City, Mexico.Gorgas Memorial Institute for Health Studies. Panama City, Panama.Universidad del Valle de Guatemala. Guatemala City, Guatemala.Universidad del Valle de Guatemala. Guatemala City, Guatemala.Infectious Diseases Clinic, Roosevelt Hospital, Guatemala City, Guatemala.Infectious Diseases Clinic, Roosevelt Hospital, Guatemala City, GuatemalaInfectious Diseases Clinic, Roosevelt Hospital, Guatemala City, GuatemalaInfectious Diseases Clinic, Roosevelt Hospital, Guatemala City, GuatemalaInfectious Diseases Clinic, Roosevelt Hospital, Guatemala City, GuatemalaInfectious Diseases Clinic, Roosevelt Hospital, Guatemala City, GuatemalaCentre for Research in Infectious Diseases. National Institute of Respiratory Diseases. Mexico City, Mexico.Centre for Research in Infectious Diseases. National Institute of Respiratory Diseases. Mexico City, Mexico.Different explanations exist on how HIV-1 subtype B spread in Central America, but the role of Guatemala, the Central American country with the highest number of people living with the virus, in this scenario is unknown. We investigated the evolutionary history and spatiotemporal dynamics of HIV-1 subtype B in Guatemala. A total of 1,047 HIV-1 subtype B pol sequences, from newly diagnosed ART-naïve, HIV-infected Guatemalan subjects enrolled between 2011 and 2013 were combined with published subtype B sequences from other Central American countries (n = 2,101) and with reference sequences representative of the BPANDEMIC and BCAR lineages from the United States (n = 465), France (n = 344) and the Caribbean (n = 238). Estimates of evolutionary, demographic, and phylogeographic parameters were obtained from sequence data using maximum likelihood and Bayesian coalescent-based methods. The majority of Guatemalan sequences (98.9%) belonged to the BPANDEMIC clade, and 75.2% of these sequences branched within 10 monophyletic clades: four also included sequences from other Central American countries (BCAM-I to BCAM-IV) and six were mostly (>99%) composed by Guatemalan sequences (BGU clades). Most clades mainly comprised sequences from heterosexual individuals. Bayesian coalescent-based analyses suggested that BGU clades originated during the 1990s and 2000s, whereas BCAM clades originated between the late 1970s and mid 1980s. The major hub of dissemination of all BGU, and of BCAM-II, and BCAM-IV clades was traced to the Department of Guatemala, while the root location of BCAM-I and BCAM-III was traced to Honduras. Most Guatemalan clades experienced initial phases of exponential growth (0.23 and 3.6 year-1), followed by recent growth declines. Our observations suggest that the Guatemalan HIV-1 subtype B epidemic is driven by dissemination of multiple BPANDEMIC founder viral strains, some restricted to Guatemala and others widely disseminated in the Central American region, with Guatemala City identified as a major hub of viral dissemination. Our results also suggest the existence of different sub-epidemics within Guatemala for which different targeted prevention efforts might be needed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31740/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALgonzalo_bello_labAIDS_etal_IOC_2018.pdfgonzalo_bello_labAIDS_etal_IOC_2018.pdfapplication/pdf12310786https://www.arca.fiocruz.br/bitstream/icict/31740/2/gonzalo_bello_labAIDS_etal_IOC_2018.pdf52c962253e59ab3dd5d8ef08e21e4727MD52TEXTgonzalo_bello_labAIDS_etal_IOC_2018.pdf.txtgonzalo_bello_labAIDS_etal_IOC_2018.pdf.txtExtracted texttext/plain61949https://www.arca.fiocruz.br/bitstream/icict/31740/3/gonzalo_bello_labAIDS_etal_IOC_2018.pdf.txt6adaf6f726dc0415f30d8028e26bbc04MD53icict/317402019-02-22 23:29:57.361oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-02-23T02:29:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala |
| title |
Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala |
| spellingShingle |
Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala Mendoza, Yaxelis História evolutiva Dinâmica espaço-temporal Subtipo B do HIV-1 Epidemia Guatemala HIV-1 subtype B Evolutionary history Spatiotemporal dynamics Guatemala Epidemic |
| title_short |
Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala |
| title_full |
Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala |
| title_fullStr |
Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala |
| title_full_unstemmed |
Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala |
| title_sort |
Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala |
| author |
Mendoza, Yaxelis |
| author_facet |
Mendoza, Yaxelis García-Morales, Claudia Bello, Gonzalo Garrido-Rodríguez, Daniela Tapia-Trejo, Daniela Pascale, Juan Miguel Girón-Callejas, Amalia Carolina Mendizábal-Burastero, Ricardo Escobar-Urias, Ingrid Yessenia García-González, Blanca Leticia Navas-Castillo, Jessenia Sabrina Quintana-Galindo, María Cristina Pinzón-Meza, Rodolfo Mejía-Villatoro, Carlos Rodolfo Avila-Ríos, Santiago Reyes-Terán, Gustavo |
| author_role |
author |
| author2 |
García-Morales, Claudia Bello, Gonzalo Garrido-Rodríguez, Daniela Tapia-Trejo, Daniela Pascale, Juan Miguel Girón-Callejas, Amalia Carolina Mendizábal-Burastero, Ricardo Escobar-Urias, Ingrid Yessenia García-González, Blanca Leticia Navas-Castillo, Jessenia Sabrina Quintana-Galindo, María Cristina Pinzón-Meza, Rodolfo Mejía-Villatoro, Carlos Rodolfo Avila-Ríos, Santiago Reyes-Terán, Gustavo |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mendoza, Yaxelis García-Morales, Claudia Bello, Gonzalo Garrido-Rodríguez, Daniela Tapia-Trejo, Daniela Pascale, Juan Miguel Girón-Callejas, Amalia Carolina Mendizábal-Burastero, Ricardo Escobar-Urias, Ingrid Yessenia García-González, Blanca Leticia Navas-Castillo, Jessenia Sabrina Quintana-Galindo, María Cristina Pinzón-Meza, Rodolfo Mejía-Villatoro, Carlos Rodolfo Avila-Ríos, Santiago Reyes-Terán, Gustavo |
| dc.subject.other.pt_BR.fl_str_mv |
História evolutiva Dinâmica espaço-temporal Subtipo B do HIV-1 Epidemia Guatemala |
| topic |
História evolutiva Dinâmica espaço-temporal Subtipo B do HIV-1 Epidemia Guatemala HIV-1 subtype B Evolutionary history Spatiotemporal dynamics Guatemala Epidemic |
| dc.subject.en.pt_BR.fl_str_mv |
HIV-1 subtype B Evolutionary history Spatiotemporal dynamics Guatemala Epidemic |
| description |
Gorgas Memorial Institute for Health Studies. Panama City, Panama / University of Panama. Department of Genetics and Molecular Biology. Panama City, Panama. |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018 |
| dc.date.accessioned.fl_str_mv |
2019-02-19T12:53:21Z |
| dc.date.available.fl_str_mv |
2019-02-19T12:53:21Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
MENDOZA, Yaxelis et al. Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala. PLoS ONE, v. 13, n. 9, p.1-21, Sept. 2018. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31740 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0203916 |
| identifier_str_mv |
MENDOZA, Yaxelis et al. Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala. PLoS ONE, v. 13, n. 9, p.1-21, Sept. 2018. 1932-6203 10.1371/journal.pone.0203916 |
| url |
https://www.arca.fiocruz.br/handle/icict/31740 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Public Library of Science |
| publisher.none.fl_str_mv |
Public Library of Science |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/31740/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/31740/2/gonzalo_bello_labAIDS_etal_IOC_2018.pdf https://www.arca.fiocruz.br/bitstream/icict/31740/3/gonzalo_bello_labAIDS_etal_IOC_2018.pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 52c962253e59ab3dd5d8ef08e21e4727 6adaf6f726dc0415f30d8028e26bbc04 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1822791916772655104 |