Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of (Zapote) Pouteria mammosa (L.) Cronquist

Detalhes bibliográficos
Autor(a) principal: Dutok, Carlos M. S.
Data de Publicação: 2015
Outros Autores: Berenguer-Rivas, Clara Azalea, Rodríguez-Leblanch, Elizabeth, Pérez-Jackson, Liliana, Chil-Nuñez, Idelsy, Escalona-Arranz, Julio César, Reyes-Tur, Bernardo, Queiroz, Margareth M. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12779
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Entomologia Médica e Forense. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biodiversidade e Saúde. Rio de Janeiro, RJ, Brasil / Universidad de Oriente. Facultad de Ciencias Naturales. Departamento de Farmácia. Santiago de Cuba, Cuba.
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spelling Dutok, Carlos M. S.Berenguer-Rivas, Clara AzaleaRodríguez-Leblanch, ElizabethPérez-Jackson, LilianaChil-Nuñez, IdelsyEscalona-Arranz, Julio CésarReyes-Tur, BernardoQueiroz, Margareth M. C.2016-02-22T15:39:38Z2016-02-22T15:39:38Z2015DUTOK, Carlos M. S. et al. Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote” Pouteria mammosa (L.) Cronquist. The Scientific World Journal, v.2015, Article ID642906, 7p, 2015.2356-6140https://www.arca.fiocruz.br/handle/icict/1277910.1155/2015/6429061537-744XengHindawi Publishing CorporationAcute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of (Zapote) Pouteria mammosa (L.) Cronquistinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Entomologia Médica e Forense. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biodiversidade e Saúde. Rio de Janeiro, RJ, Brasil / Universidad de Oriente. Facultad de Ciencias Naturales. Departamento de Farmácia. Santiago de Cuba, Cuba.Universidad de Ciencias Médicas de Santiago de Cuba. Centro de Toxicología y Biomedicina. Santiago de Cuba, Cuba.Universidad de Ciencias Médicas de Santiago de Cuba. Centro de Toxicología y Biomedicina. Santiago de Cuba, Cuba.Universidad de Ciencias Médicas de Santiago de Cuba. Centro de Toxicología y Biomedicina. Santiago de Cuba, Cuba.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Entomologia Médica e Forense. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biodiversidade e Saúde. Rio de Janeiro, RJ, Brasil / Universidad de Oriente. Facultad de Ciencias Naturales. Departamento de Farmácia. Santiago de Cuba, Cuba.Universidad de Oriente. Facultad de Ciencias Naturales. Departamento de Farmácia. Santiago de Cuba, Cuba.Universidad de Oriente. Facultad de Ciencias Naturales. Departamento de Biologia. Santiago de Cuba, Cuba.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Entomologia Médica e Forense. Rio de Janeiro, RJ, BrasilThe common use of Pouteria mammosa (L.) Cronquist, “Mamey or Zapote,” in food and ethnobotanic medicine shows its low or absent toxicity as fruit extracts prepared from seeds. However, it is essential to conduct security trials to scientifically support their use in drug therapy. This study evaluated the aqueous and hydroalcoholic extract (25%) Acute Oral Toxicity, obtained from the seeds of P. mammosa, in Sprague Dawley rats and dermal and eye irritability in New Zealand rabbits. The 404 and 405 acute dermal and eye irritation/corrosion guidelines were used, as well as the 423 Acute Oral Toxicity guideline, Acute Toxic Class Method of the Organization for Economic Cooperation and Development (OECD). The aqueous extract was located in the following category: not classified as toxic (CTA 5), while hydroalcoholic extract at 25% was classified as dangerous (CTA 4). Both extracts can be used without side reaction that irritates the skin which permitted classification as potentially not irritant. P. mammosa in the two extracts caused mild and reversible eye irritation, and it was classified as slightly irritating.Acute toxicityHydroalcoholic ExtractsEye IrritationSeedsPouteria mammosa (L.) CronquistToxicidade AgudaHidroalcoólicaSementesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12779/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcarlos_dutok_etal_IOC_2015.pdfcarlos_dutok_etal_IOC_2015.pdfapplication/pdf1308275https://www.arca.fiocruz.br/bitstream/icict/12779/2/carlos_dutok_etal_IOC_2015.pdfb8d80050a440b8b907569f67b2d3f5fdMD52TEXTcarlos_dutok_etal_IOC_2015.pdf.txtcarlos_dutok_etal_IOC_2015.pdf.txtExtracted texttext/plain32884https://www.arca.fiocruz.br/bitstream/icict/12779/3/carlos_dutok_etal_IOC_2015.pdf.txt9b7a26ff690352539953b66d6eb40274MD53icict/127792018-04-02 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dc.title.pt_BR.fl_str_mv Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of (Zapote) Pouteria mammosa (L.) Cronquist
title Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of (Zapote) Pouteria mammosa (L.) Cronquist
spellingShingle Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of (Zapote) Pouteria mammosa (L.) Cronquist
Dutok, Carlos M. S.
Acute toxicity
Hydroalcoholic Extracts
Eye Irritation
Seeds
Pouteria mammosa (L.) Cronquist
Toxicidade Aguda
Hidroalcoólica
Sementes
title_short Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of (Zapote) Pouteria mammosa (L.) Cronquist
title_full Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of (Zapote) Pouteria mammosa (L.) Cronquist
title_fullStr Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of (Zapote) Pouteria mammosa (L.) Cronquist
title_full_unstemmed Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of (Zapote) Pouteria mammosa (L.) Cronquist
title_sort Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of (Zapote) Pouteria mammosa (L.) Cronquist
author Dutok, Carlos M. S.
author_facet Dutok, Carlos M. S.
Berenguer-Rivas, Clara Azalea
Rodríguez-Leblanch, Elizabeth
Pérez-Jackson, Liliana
Chil-Nuñez, Idelsy
Escalona-Arranz, Julio César
Reyes-Tur, Bernardo
Queiroz, Margareth M. C.
author_role author
author2 Berenguer-Rivas, Clara Azalea
Rodríguez-Leblanch, Elizabeth
Pérez-Jackson, Liliana
Chil-Nuñez, Idelsy
Escalona-Arranz, Julio César
Reyes-Tur, Bernardo
Queiroz, Margareth M. C.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dutok, Carlos M. S.
Berenguer-Rivas, Clara Azalea
Rodríguez-Leblanch, Elizabeth
Pérez-Jackson, Liliana
Chil-Nuñez, Idelsy
Escalona-Arranz, Julio César
Reyes-Tur, Bernardo
Queiroz, Margareth M. C.
dc.subject.en.pt_BR.fl_str_mv Acute toxicity
Hydroalcoholic Extracts
Eye Irritation
Seeds
Pouteria mammosa (L.) Cronquist
topic Acute toxicity
Hydroalcoholic Extracts
Eye Irritation
Seeds
Pouteria mammosa (L.) Cronquist
Toxicidade Aguda
Hidroalcoólica
Sementes
dc.subject.decs.pt_BR.fl_str_mv Toxicidade Aguda
Hidroalcoólica
Sementes
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Entomologia Médica e Forense. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biodiversidade e Saúde. Rio de Janeiro, RJ, Brasil / Universidad de Oriente. Facultad de Ciencias Naturales. Departamento de Farmácia. Santiago de Cuba, Cuba.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-02-22T15:39:38Z
dc.date.available.fl_str_mv 2016-02-22T15:39:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv DUTOK, Carlos M. S. et al. Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote” Pouteria mammosa (L.) Cronquist. The Scientific World Journal, v.2015, Article ID642906, 7p, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12779
dc.identifier.issn.none.fl_str_mv 2356-6140
dc.identifier.doi.none.fl_str_mv 10.1155/2015/642906
dc.identifier.eissn.none.fl_str_mv 1537-744X
identifier_str_mv DUTOK, Carlos M. S. et al. Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote” Pouteria mammosa (L.) Cronquist. The Scientific World Journal, v.2015, Article ID642906, 7p, 2015.
2356-6140
10.1155/2015/642906
1537-744X
url https://www.arca.fiocruz.br/handle/icict/12779
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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