COVID-19, leprosy, and neutrophils

Detalhes bibliográficos
Autor(a) principal: Schmitz, Veronica
Data de Publicação: 2021
Outros Autores: Santos, Jéssica Brandão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46256
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
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spelling Schmitz, VeronicaSantos, Jéssica Brandão dos2021-03-04T13:45:14Z2021-03-04T13:45:14Z2021SCHMITZ, Veronica; SANTOS, Jèssica Brandão dos. COVID-19, leprosy, and neutrophils. PLoS Neglected Tropical Diseases, v, 15, n. 1, e0009019, p. 1-5, Jan. 2021.1935-2727https://www.arca.fiocruz.br/handle/icict/4625610.1371/journal.pntd.0009019engPublic Library of ScienceCOVID-19NeutrófilosHanseniaseCOVID-19NeutrophilsLeprosyCOVID-19, leprosy, and neutrophilsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Coronavirus Disease 2019 (COVID-19), a disease caused by the betacoronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has only recently emerged, while Mycobacterium leprae, the etiological agent of leprosy, has endured for more than 2,000 years. As soon as the initial reports of COVID-19 became public, several entities, including the Brazilian Leprosy Society, warned about the possible impact of COVID-19 on leprosy patients. It has been verified that COVID-19 carriers can be either asymptomatic or present varying degrees of severe respiratory failure in association with cytokine storm and death, among other diseases. Severe COVID-19 patients show increased numbers of neutrophils and serum neutrophil extracellular trap (NET) markers, in addition to alterations in the neutrophil-to-lymphocyte ratio (NLR). The absence of antiviral drugs and the speed of COVID-19 transmission have had a major impact on public health systems worldwide, leading to the almost total collapse of many national and local healthcare services. Leprosy, an infectious neurological and dermatological illness, is widely considered to be the most frequent cause of physical disabilities globally. The chronic clinical course of the disease may be interrupted by acute inflammatory episodes, named leprosy reactions. These serious immunological complications, characterized by cytokine storms, are responsible for amplifying peripheral nerve damage. From 30% to 40% of all multibacillary leprosy (MB) patients experience erythema nodosum leprosum (ENL), a neutrophilic immune-mediated condition. ENL patients often present these same COVID-19-like symptoms, including high levels of serum NET markers, altered NLR, and neutrophilia. Moreover, the consequences of a M. leprae–SARS-CoV-2 coinfection have yet to be fully investigated. The goal of the present viewpoint is to describe some of the similarities that may be found between COVID-19 and leprosy disease in the context of neutrophilic biology.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46256/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSchmitz_Veronica_etal_IOC_2021_COVID-19.pdfSchmitz_Veronica_etal_IOC_2021_COVID-19.pdfapplication/pdf302972https://www.arca.fiocruz.br/bitstream/icict/46256/2/Schmitz_Veronica_etal_IOC_2021_COVID-19.pdf2b9ae10ba0b27929f46b20891915e194MD52TEXTSchmitz_Veronica_etal_IOC_2021_COVID-19.pdf.txtSchmitz_Veronica_etal_IOC_2021_COVID-19.pdf.txtExtracted texttext/plain19169https://www.arca.fiocruz.br/bitstream/icict/46256/3/Schmitz_Veronica_etal_IOC_2021_COVID-19.pdf.txt7b40f45d3540aeae549fcb601df8c6abMD53icict/462562021-03-05 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dc.title.pt_BR.fl_str_mv COVID-19, leprosy, and neutrophils
title COVID-19, leprosy, and neutrophils
spellingShingle COVID-19, leprosy, and neutrophils
Schmitz, Veronica
COVID-19
Neutrófilos
Hanseniase
COVID-19
Neutrophils
Leprosy
title_short COVID-19, leprosy, and neutrophils
title_full COVID-19, leprosy, and neutrophils
title_fullStr COVID-19, leprosy, and neutrophils
title_full_unstemmed COVID-19, leprosy, and neutrophils
title_sort COVID-19, leprosy, and neutrophils
author Schmitz, Veronica
author_facet Schmitz, Veronica
Santos, Jéssica Brandão dos
author_role author
author2 Santos, Jéssica Brandão dos
author2_role author
dc.contributor.author.fl_str_mv Schmitz, Veronica
Santos, Jéssica Brandão dos
dc.subject.other.pt_BR.fl_str_mv COVID-19
Neutrófilos
Hanseniase
topic COVID-19
Neutrófilos
Hanseniase
COVID-19
Neutrophils
Leprosy
dc.subject.en.pt_BR.fl_str_mv COVID-19
Neutrophils
Leprosy
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-03-04T13:45:14Z
dc.date.available.fl_str_mv 2021-03-04T13:45:14Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCHMITZ, Veronica; SANTOS, Jèssica Brandão dos. COVID-19, leprosy, and neutrophils. PLoS Neglected Tropical Diseases, v, 15, n. 1, e0009019, p. 1-5, Jan. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46256
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0009019
identifier_str_mv SCHMITZ, Veronica; SANTOS, Jèssica Brandão dos. COVID-19, leprosy, and neutrophils. PLoS Neglected Tropical Diseases, v, 15, n. 1, e0009019, p. 1-5, Jan. 2021.
1935-2727
10.1371/journal.pntd.0009019
url https://www.arca.fiocruz.br/handle/icict/46256
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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