The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis

Oliveira, Walker Nonato; Ribeiro, Luís Eduardo; Schrieffer, Albert; Machado, Paulo; Carvalho Filho, Edgar Marcelino; Bacellar, Olívia

The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis

Detalhes bibliográficos
Autor(a) principal:	Oliveira, Walker Nonato
Data de Publicação:	2014
Outros Autores:	Ribeiro, Luís Eduardo, Schrieffer, Albert, Machado, Paulo, Carvalho Filho, Edgar Marcelino, Bacellar, Olívia
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/25498
Resumo:	Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.

Metadados do item

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spelling	Oliveira, Walker NonatoRibeiro, Luís EduardoSchrieffer, AlbertMachado, PauloCarvalho Filho, Edgar MarcelinoBacellar, Olívia2018-03-26T18:16:54Z2018-03-26T18:16:54Z2014OLIVEIRA, W. N. et al. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis. Cytokine, v. 66, n. 2, p. 127–132, 2014.1043-4666https://www.arca.fiocruz.br/handle/icict/2549810.1016/j.cyto.2013.12.016Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.National Institute of Health (NIH) grant AI30639–20.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / bInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / bInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / bInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / bInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / bInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilIn tegumentary leishmaniasis caused by Leishmania braziliensis, there is evidence that increased production of IFN-γ, TNF-α and absence of IL-10 is associated with strong inflammatory reaction and with tissue destruction and development of the lesions observed in cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML). We evaluate the role of regulatory cytokines and cytokine antagonists in the downregulation of immune response in L. braziliensis infection. Peripheral blood mononuclear cells from CL and ML were stimulated with soluble Leishmania antigen in the presence or absence of regulatory cytokines (IL-10, IL-27 and TGF-β) or antagonists of cytokines (α-TNF-α and α-IFN-γ). Cytokines production (IL-10, IL-17, TNF-α and IFN-γ) was measured by ELISA. IL-10 and TGF-β downmodulate TNF-α and IL-17 production, whereas IL-27 had no effect in the production of TNF-α, IFN-γ and IL-17 in these patients. Neutralization of TNF-α decreased IFN-γ level and the neutralization of IFN-γ decreased TNF-α level and increased IL-10 production. This study demonstrate that IL-10 and TGF-β are cytokines that appear to be more involved in modulation of immune response in CL and ML patients. IL-10 might have a protective role, since the neutralization of IFN-γ decreases the production of TNF-α in an IL-10-dependent manner.engElsevierLeishmanioseLeishmania braziliensisImunopatogêneseCitocinas reguladorasHuman american tegumentaryLeishmaniasisLeishmania braziliensisImmunopathogenesisRegulatory cytokinesThe role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25498/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOliveira WN The role of inflammatory and anti-inflammatory....pdfOliveira WN The role of inflammatory and 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dc.title.pt_BR.fl_str_mv	The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis
title	The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis
spellingShingle	The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis Oliveira, Walker Nonato Leishmaniose Leishmania braziliensis Imunopatogênese Citocinas reguladoras Human american tegumentary Leishmaniasis Leishmania braziliensis Immunopathogenesis Regulatory cytokines
title_short	The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis
title_full	The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis
title_fullStr	The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis
title_full_unstemmed	The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis
title_sort	The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis
author	Oliveira, Walker Nonato
author_facet	Oliveira, Walker Nonato Ribeiro, Luís Eduardo Schrieffer, Albert Machado, Paulo Carvalho Filho, Edgar Marcelino Bacellar, Olívia
author_role	author
author2	Ribeiro, Luís Eduardo Schrieffer, Albert Machado, Paulo Carvalho Filho, Edgar Marcelino Bacellar, Olívia
author2_role	author author author author author
dc.contributor.author.fl_str_mv	Oliveira, Walker Nonato Ribeiro, Luís Eduardo Schrieffer, Albert Machado, Paulo Carvalho Filho, Edgar Marcelino Bacellar, Olívia
dc.subject.other.pt_BR.fl_str_mv	Leishmaniose Leishmania braziliensis Imunopatogênese Citocinas reguladoras
topic	Leishmaniose Leishmania braziliensis Imunopatogênese Citocinas reguladoras Human american tegumentary Leishmaniasis Leishmania braziliensis Immunopathogenesis Regulatory cytokines
dc.subject.en.pt_BR.fl_str_mv	Human american tegumentary Leishmaniasis Leishmania braziliensis Immunopathogenesis Regulatory cytokines
description	Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate	2014
dc.date.issued.fl_str_mv	2014
dc.date.accessioned.fl_str_mv	2018-03-26T18:16:54Z
dc.date.available.fl_str_mv	2018-03-26T18:16:54Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	OLIVEIRA, W. N. et al. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis. Cytokine, v. 66, n. 2, p. 127–132, 2014.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/25498
dc.identifier.issn.pt_BR.fl_str_mv	1043-4666
dc.identifier.doi.none.fl_str_mv	10.1016/j.cyto.2013.12.016
identifier_str_mv	OLIVEIRA, W. N. et al. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis. Cytokine, v. 66, n. 2, p. 127–132, 2014. 1043-4666 10.1016/j.cyto.2013.12.016
url	https://www.arca.fiocruz.br/handle/icict/25498
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/25498/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/25498/2/Oliveira%20WN%20The%20role%20of%20inflammatory%20and%20anti-inflammatory....pdf https://www.arca.fiocruz.br/bitstream/icict/25498/3/Oliveira%20WN%20The%20role%20of%20inflammatory%20and%20anti-inflammatory....pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis

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