Tumor Necrosis Factor-α in Human American Tegumentary Leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Cruz, Alda Maria da
Data de Publicação: 1996
Outros Autores: Oliveira, Márcia Pereira de, De Luca, Paula Mello, Mendonça, Sergio C. F., Coutinho, Sergio G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33636
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunidade Celular e Hormonal. Rio de Janeiro, RJ, Brasil.
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spelling Cruz, Alda Maria daOliveira, Márcia Pereira deDe Luca, Paula MelloMendonça, Sergio C. F.Coutinho, Sergio G.2019-06-24T16:36:47Z2019-06-24T16:36:47Z1996CRUZ, Alda Maria da et al. Tumor Necrosis Factor-α in Human American Tegumentary Leishmaniasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 97, n. 2, p. 225-229, Mar./Apr. 1996.0074-0276https://www.arca.fiocruz.br/handle/icict/3363610.1590/S0074-027619960002000191678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.TNF-αCitocinasLeishmania braziliensisLeishmaniose tegumentarTNF-αCytokineTegumentary leishmaniasisLeishmania braziliensisTumor Necrosis Factor-α in Human American Tegumentary Leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunidade Celular e Hormonal. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunidade Celular e Hormonal. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunidade Celular e Hormonal. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunidade Celular e Hormonal. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunidade Celular e Hormonal. Rio de Janeiro, RJ, Brasil.Tumor necrosis factor-alpha (TNFα ) is a cytokine produced by activated macrophages and other cells. In order to verify whether the serum levels of TNFα in American tegumentary leishmaniasis patients are associated with the process of cure or aggravation of the disease, 41 patients were studied: 26 cases of cutaneous leishmaniasis (CL) and 15 of mucocutaneous leishmaniasis (MCL). During active disease the serum levels of TNFα of MCL patients were significantly higher than those of CL patients and control subjects (healthy individuals and cutaneous lesions from other etiologies). The MCL patients had serum titers of TNFα significantly lower at the end of antimonial therapy than before therapy. After a six-month follow-up, the MCL patients had serum levels of TNFα similar to those observed at the end of the therapy as well as to those of CL patients and control subjects. No significant variation in the serum levels of TNFα was observed in CL patients throughout the study period (before, at the end of therapy and after a six-month follow-up). The possible relationship between the high TNFα serum levels and severity of the disease is discussed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33636/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAldaCruz_PaulaLuca_etal_IOC_1996.pdfAldaCruz_PaulaLuca_etal_IOC_1996.pdfapplication/pdf121548https://www.arca.fiocruz.br/bitstream/icict/33636/2/AldaCruz_PaulaLuca_etal_IOC_1996.pdf8331138a51ba13c966948161fbdbd2c8MD52TEXTAldaCruz_PaulaLuca_etal_IOC_1996.pdf.txtAldaCruz_PaulaLuca_etal_IOC_1996.pdf.txtExtracted texttext/plain22788https://www.arca.fiocruz.br/bitstream/icict/33636/3/AldaCruz_PaulaLuca_etal_IOC_1996.pdf.txt8bd56a886cde45d7fda461539dac6532MD53icict/336362019-06-25 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dc.title.pt_BR.fl_str_mv Tumor Necrosis Factor-α in Human American Tegumentary Leishmaniasis
title Tumor Necrosis Factor-α in Human American Tegumentary Leishmaniasis
spellingShingle Tumor Necrosis Factor-α in Human American Tegumentary Leishmaniasis
Cruz, Alda Maria da
TNF-α
Citocinas
Leishmania braziliensis
Leishmaniose tegumentar
TNF-α
Cytokine
Tegumentary leishmaniasis
Leishmania braziliensis
title_short Tumor Necrosis Factor-α in Human American Tegumentary Leishmaniasis
title_full Tumor Necrosis Factor-α in Human American Tegumentary Leishmaniasis
title_fullStr Tumor Necrosis Factor-α in Human American Tegumentary Leishmaniasis
title_full_unstemmed Tumor Necrosis Factor-α in Human American Tegumentary Leishmaniasis
title_sort Tumor Necrosis Factor-α in Human American Tegumentary Leishmaniasis
author Cruz, Alda Maria da
author_facet Cruz, Alda Maria da
Oliveira, Márcia Pereira de
De Luca, Paula Mello
Mendonça, Sergio C. F.
Coutinho, Sergio G.
author_role author
author2 Oliveira, Márcia Pereira de
De Luca, Paula Mello
Mendonça, Sergio C. F.
Coutinho, Sergio G.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cruz, Alda Maria da
Oliveira, Márcia Pereira de
De Luca, Paula Mello
Mendonça, Sergio C. F.
Coutinho, Sergio G.
dc.subject.other.pt_BR.fl_str_mv TNF-α
Citocinas
Leishmania braziliensis
Leishmaniose tegumentar
topic TNF-α
Citocinas
Leishmania braziliensis
Leishmaniose tegumentar
TNF-α
Cytokine
Tegumentary leishmaniasis
Leishmania braziliensis
dc.subject.en.pt_BR.fl_str_mv TNF-α
Cytokine
Tegumentary leishmaniasis
Leishmania braziliensis
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunidade Celular e Hormonal. Rio de Janeiro, RJ, Brasil.
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2019-06-24T16:36:47Z
dc.date.available.fl_str_mv 2019-06-24T16:36:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CRUZ, Alda Maria da et al. Tumor Necrosis Factor-α in Human American Tegumentary Leishmaniasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 97, n. 2, p. 225-229, Mar./Apr. 1996.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33636
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02761996000200019
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv CRUZ, Alda Maria da et al. Tumor Necrosis Factor-α in Human American Tegumentary Leishmaniasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 97, n. 2, p. 225-229, Mar./Apr. 1996.
0074-0276
10.1590/S0074-02761996000200019
1678-8060
url https://www.arca.fiocruz.br/handle/icict/33636
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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