Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5444 |
Resumo: | texto completo: acesso restrito. p.438– 444. |
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Machado, Paulo Roberto LimaRosa, Maria Elisa AlvesCosta, Diego LuisMignac, MoemaSilva, João S.Schriefer, Nicolaus Albert BorgesTeixeira, Mauro M.Bacellar, Maria Olívia Amado RamosCarvalho Filho, Edgar Marcelino deMachado, Paulo Roberto LimaRosa, Maria Elisa AlvesCosta, Diego LuisMignac, MoemaSilva, João S.Schriefer, Nicolaus Albert BorgesTeixeira, Mauro M.Bacellar, Maria Olívia Amado RamosCarvalho Filho, Edgar Marcelino de2012-02-25T12:02:19Z20111878-3503http://www.repositorio.ufba.br/ri/handle/ri/5444v. 105.texto completo: acesso restrito. p.438– 444.Disseminated leishmaniasis (DL) is an emerging form of Leishmania braziliensis infection characterised by multiple cutaneous lesions on different parts of the body and a high rate of mucosal involvement. Systemic production of TNFa and IFNg in DL patients is lower than in cutaneous leishmaniasis (CL) caused by L. braziliensis, which may account for parasite dissemination due to the decreased ability to control parasite growth. In this study, the systemic and in situ immune response of DL and CL patients was characterised through evaluation of chemokine and cytokine production. In situ evaluation showed similar production of IFNg, TNFa, IL10, transforming growth factorbeta (TGFb), chemokine (CC motif) ligand 2 (CCL2), CCL3, CCL11 and chemokine (CXC motif) ligand 10 (CXCL10) in papular and ulcerative lesions from DL as well as in ulcerated lesions from CL. Serum levels of CXCL9, a chemokine that attracts Tcells, was higher in serum from DL than from CL. These data indicate that a decrease in the type 1 immune response in peripheral blood of DL patients is due to attraction of Leishmania antigenactivated Tcells to the multiple cutaneous lesions. This may account for the absence of or few parasites in the lesions and for the development of ulcers similar to those observed in CL.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-02-25T12:02:19Z No. of bitstreams: 1 nps50.tmp.pdf: 382472 bytes, checksum: 827c12bb8903016e709dd6b6dcb06c91 (MD5)Made available in DSpace on 2012-02-25T12:02:19Z (GMT). No. of bitstreams: 1 nps50.tmp.pdf: 382472 bytes, checksum: 827c12bb8903016e709dd6b6dcb06c91 (MD5) Previous issue date: 2011doi:10.1016/j.trstmh.2011.05.002reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACytokinesChemokinesDisseminated leishmaniasisLeishmania braziliensisImmunopathogenesisCutaneous leishmaniasisReappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune responseTransactions of the Royal Society of Tropical Medicine and Hygieneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALnps50.tmp.pdfnps50.tmp.pdfapplication/pdf382472https://repositorio.ufba.br/bitstream/ri/5444/1/nps50.tmp.pdf827c12bb8903016e709dd6b6dcb06c91MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5444/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTnps50.tmp.pdf.txtnps50.tmp.pdf.txtExtracted texttext/plain28522https://repositorio.ufba.br/bitstream/ri/5444/3/nps50.tmp.pdf.txt114b48065caaf9400776f403a334f252MD53ri/54442022-07-05 14:03:44.702oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:44Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response |
| dc.title.alternative.pt_BR.fl_str_mv |
Transactions of the Royal Society of Tropical Medicine and Hygiene |
| title |
Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response |
| spellingShingle |
Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response Machado, Paulo Roberto Lima Cytokines Chemokines Disseminated leishmaniasis Leishmania braziliensis Immunopathogenesis Cutaneous leishmaniasis |
| title_short |
Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response |
| title_full |
Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response |
| title_fullStr |
Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response |
| title_full_unstemmed |
Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response |
| title_sort |
Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response |
| author |
Machado, Paulo Roberto Lima |
| author_facet |
Machado, Paulo Roberto Lima Rosa, Maria Elisa Alves Costa, Diego Luis Mignac, Moema Silva, João S. Schriefer, Nicolaus Albert Borges Teixeira, Mauro M. Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Rosa, Maria Elisa Alves Costa, Diego Luis Mignac, Moema Silva, João S. Schriefer, Nicolaus Albert Borges Teixeira, Mauro M. Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Machado, Paulo Roberto Lima Rosa, Maria Elisa Alves Costa, Diego Luis Mignac, Moema Silva, João S. Schriefer, Nicolaus Albert Borges Teixeira, Mauro M. Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de Machado, Paulo Roberto Lima Rosa, Maria Elisa Alves Costa, Diego Luis Mignac, Moema Silva, João S. Schriefer, Nicolaus Albert Borges Teixeira, Mauro M. Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de |
| dc.subject.por.fl_str_mv |
Cytokines Chemokines Disseminated leishmaniasis Leishmania braziliensis Immunopathogenesis Cutaneous leishmaniasis |
| topic |
Cytokines Chemokines Disseminated leishmaniasis Leishmania braziliensis Immunopathogenesis Cutaneous leishmaniasis |
| description |
texto completo: acesso restrito. p.438– 444. |
| publishDate |
2011 |
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2011 |
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2012-02-25T12:02:19Z |
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info:eu-repo/semantics/publishedVersion |
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1878-3503 |
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v. 105. |
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1878-3503 v. 105. |
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http://www.repositorio.ufba.br/ri/handle/ri/5444 |
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