Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.

Alcantara, Luiz Carlos Júnior; Shindo, Nice; Van Dooren, Sonia; Salemi, Marco; Costa, Maria Cristina Ramos; Kashima, Simone G; Covas, Dimas Tadeu; Vandamme, Anne-Mieke

Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.

Detalhes bibliográficos
Autor(a) principal:	Alcantara, Luiz Carlos Júnior
Data de Publicação:	2003
Outros Autores:	Shindo, Nice, Van Dooren, Sonia, Salemi, Marco, Costa, Maria Cristina Ramos, Kashima, Simone G, Covas, Dimas Tadeu, Vandamme, Anne-Mieke
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/3883
Resumo:	Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil

Metadados do item

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spelling	Alcantara, Luiz Carlos JúniorShindo, NiceVan Dooren, SoniaSalemi, MarcoCosta, Maria Cristina RamosKashima, Simone GCovas, Dimas TadeuVandamme, Anne-Mieke2012-05-04T19:42:09Z2012-05-04T19:42:09Z2003ALCANTARA, L.C. et al. Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs. AIDS Research and Human Retroviruses, v. 19, n. 6, p. 519-523, jun. 2003.0889-2229https://www.arca.fiocruz.br/handle/icict/3883engBrazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilKatholieke Universiteit Leuven. Rega Institute for Medical Research. Leuven, BelgiumKatholieke Universiteit Leuven. Rega Institute for Medical Research. Leuven, BelgiumBlood Center of Ribeirão Preto. São Paulo, SP, BrasilBlood Center of Ribeirão Preto. São Paulo, SP, BrasilBlood Center of Ribeirão Preto. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilIn Brazil, HTLV-2 has been detected in blood donors, in intravenous drug users (IDUs) from urban areas, and in Amerindians living in the Amazon basin. Of the three main HTLV-2 subtypes (2a, 2b, and 2d) only subtype 2a has been detected in Brazil. However, a molecular variant of subtype 2a (also called HTLV-2c) characterized by an extended Tax protein has been isolated from Brazilian blood donors, IDUs, and Indians. Here, we analyzed HTLV-2 isolates from 10 IDUs and a Chilean woman living in Salvador, Bahia, Brazil. Sequencing of env, pX, and long terminal repeat (LTR) genes demonstrated that 10 of the isolates are related to the Brazilian subtype 2a molecular variant described previously. We show that most HTLV-2a Brazilian strains comprise a phylogenetic group harboring a considerable degree of diversity within the env region but not within the LTR region. Interestingly, we demonstrated for the first time in Brazil the presence of a subtype 2a in IDUs that is closely related to the prototype Mo but distinct from the Brazilian 2a molecular variant.Infecções por HTLV-II/epidemiologiaVírus 2 Linfotrópico T Humano/classificaçãoÍndios Sul-AmericanosAbuso de Substâncias por ViaIntravenosa/complicaçõesEuropa (Continente)/epidemiologiaProdutos do Gene env/químicaDados de Sequência MolecularFilogeniaProteínas Oncogênicas de Retroviridae/químicaAnálise de Sequência de DNASequências Repetidas Terminais/genéticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAlcantara LC Brazilian HTLV type 2a....pdfAlcantara LC Brazilian HTLV type 2a....pdfapplication/pdf168876https://www.arca.fiocruz.br/bitstream/icict/3883/1/Alcantara%20LC%20Brazilian%20HTLV%20type%202a....pdf8115dc10b8ede35a481fcc50c6fb6251MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3883/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTAlcantara LC Brazilian HTLV type 2a....pdf.txtAlcantara LC Brazilian HTLV type 2a....pdf.txtExtracted texttext/plain17319https://www.arca.fiocruz.br/bitstream/icict/3883/5/Alcantara%20LC%20Brazilian%20HTLV%20type%202a....pdf.txt147d45a9749b5f6f7671e534c31ac1d5MD55THUMBNAILAlcantara LC Brazilian HTLV type 2a....pdf.jpgAlcantara LC Brazilian HTLV type 2a....pdf.jpgGenerated Thumbnailimage/jpeg2410https://www.arca.fiocruz.br/bitstream/icict/3883/4/Alcantara%20LC%20Brazilian%20HTLV%20type%202a....pdf.jpgf00b10cc357eb9b64997bc548b5fe0bcMD54icict/38832023-03-15 14:34:02.851oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.
title	Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.
spellingShingle	Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs. Alcantara, Luiz Carlos Júnior Infecções por HTLV-II/epidemiologia Vírus 2 Linfotrópico T Humano/classificação Índios Sul-Americanos Abuso de Substâncias por Via Intravenosa/complicações Europa (Continente)/epidemiologia Produtos do Gene env/química Dados de Sequência Molecular Filogenia Proteínas Oncogênicas de Retroviridae/química Análise de Sequência de DNA Sequências Repetidas Terminais/genética
title_short	Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.
title_full	Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.
title_fullStr	Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.
title_full_unstemmed	Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.
title_sort	Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.
author	Alcantara, Luiz Carlos Júnior
author_facet	Alcantara, Luiz Carlos Júnior Shindo, Nice Van Dooren, Sonia Salemi, Marco Costa, Maria Cristina Ramos Kashima, Simone G Covas, Dimas Tadeu Vandamme, Anne-Mieke
author_role	author
author2	Shindo, Nice Van Dooren, Sonia Salemi, Marco Costa, Maria Cristina Ramos Kashima, Simone G Covas, Dimas Tadeu Vandamme, Anne-Mieke
author2_role	author author author author author author author
dc.contributor.author.fl_str_mv	Alcantara, Luiz Carlos Júnior Shindo, Nice Van Dooren, Sonia Salemi, Marco Costa, Maria Cristina Ramos Kashima, Simone G Covas, Dimas Tadeu Vandamme, Anne-Mieke
dc.subject.decs.pt_BR.fl_str_mv	Infecções por HTLV-II/epidemiologia Vírus 2 Linfotrópico T Humano/classificação Índios Sul-Americanos Abuso de Substâncias por Via Intravenosa/complicações Europa (Continente)/epidemiologia Produtos do Gene env/química Dados de Sequência Molecular Filogenia Proteínas Oncogênicas de Retroviridae/química Análise de Sequência de DNA Sequências Repetidas Terminais/genética
topic	Infecções por HTLV-II/epidemiologia Vírus 2 Linfotrópico T Humano/classificação Índios Sul-Americanos Abuso de Substâncias por Via Intravenosa/complicações Europa (Continente)/epidemiologia Produtos do Gene env/química Dados de Sequência Molecular Filogenia Proteínas Oncogênicas de Retroviridae/química Análise de Sequência de DNA Sequências Repetidas Terminais/genética
description	Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
publishDate	2003
dc.date.issued.fl_str_mv	2003
dc.date.accessioned.fl_str_mv	2012-05-04T19:42:09Z
dc.date.available.fl_str_mv	2012-05-04T19:42:09Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv	ALCANTARA, L.C. et al. Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs. AIDS Research and Human Retroviruses, v. 19, n. 6, p. 519-523, jun. 2003.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/3883
dc.identifier.issn.none.fl_str_mv	0889-2229
identifier_str_mv	ALCANTARA, L.C. et al. Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs. AIDS Research and Human Retroviruses, v. 19, n. 6, p. 519-523, jun. 2003. 0889-2229
url	https://www.arca.fiocruz.br/handle/icict/3883
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
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Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.

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