The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review

Detalhes bibliográficos
Autor(a) principal: Krettli, Antoniana U.
Data de Publicação: 2001
Outros Autores: Andrade-Neto, Valter F., Brandão, Maria das Graças L., Ferrari, Wanêssa M. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57704
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
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spelling Krettli, Antoniana U.Andrade-Neto, Valter F.Brandão, Maria das Graças L.Ferrari, Wanêssa M. S.2023-04-06T18:24:26Z2023-04-06T18:24:26Z2001KRETLI, Antoniana U. et al. The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 8, p. 1033-1042, Nov. 2001.0074-0276https://www.arca.fiocruz.br/handle/icict/5770410.1590/S0074-02762001000800002engFiocruz/IOCThe search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Laboratório de Farmacognosia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.In this review we discuss the ongoing situation of human malaria in the Brazilian Amazon, where it is endemic causing over 610,000 new acute cases yearly, a number which is on the increase. This is partly a result of drug resistant parasites and new antimalarial drugs are urgently needed. The approaches we have used in the search of new drugs during decades are now reviewed and include ethnopharmocology, plants randomly selected, extracts or isolated substances from plants shown to be active against the blood stage parasites in our previous studies. Emphasis is given on the medicinal plant Bidens pilosa, proven to be active against the parasite blood stages in tests using freshly prepared plant extracts. The anti-sporozoite activity of one plant used in the Brazilian endemic area to prevent malaria is also described, the so called "Indian beer" (Ampelozizyphus amazonicus, Rhamnaceae). Freshly prepared extracts from the roots of this plant were totally inactive against blood stage parasites, but active against sporozoites of Plasmodium gallinaceum or the primary exoerythrocytic stages reducing tissue parasitism in inoculated chickens. This result will be of practical importance if confirmed in mammalian malaria. Problems and perspectives in the search for antimalarial drugs are discussed as well as the toxicological and clinical trials to validate some of the active plants for public health use in Brazil.Antimalarial drugsPlant extractsHuman malariaPlasmodium falciparumEthnopharmacologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57704/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALKrettli_Antoniana_etal_IRR_2001.pdfKrettli_Antoniana_etal_IRR_2001.pdfapplication/pdf131382https://www.arca.fiocruz.br/bitstream/icict/57704/2/Krettli_Antoniana_etal_IRR_2001.pdf400ac76c45ab38feed7fdf4bfdf3145dMD52icict/577042023-04-08 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dc.title.en_US.fl_str_mv The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review
title The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review
spellingShingle The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review
Krettli, Antoniana U.
Antimalarial drugs
Plant extracts
Human malaria
Plasmodium falciparum
Ethnopharmacology
title_short The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review
title_full The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review
title_fullStr The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review
title_full_unstemmed The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review
title_sort The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review
author Krettli, Antoniana U.
author_facet Krettli, Antoniana U.
Andrade-Neto, Valter F.
Brandão, Maria das Graças L.
Ferrari, Wanêssa M. S.
author_role author
author2 Andrade-Neto, Valter F.
Brandão, Maria das Graças L.
Ferrari, Wanêssa M. S.
author2_role author
author
author
dc.contributor.author.fl_str_mv Krettli, Antoniana U.
Andrade-Neto, Valter F.
Brandão, Maria das Graças L.
Ferrari, Wanêssa M. S.
dc.subject.en.en_US.fl_str_mv Antimalarial drugs
Plant extracts
Human malaria
Plasmodium falciparum
Ethnopharmacology
topic Antimalarial drugs
Plant extracts
Human malaria
Plasmodium falciparum
Ethnopharmacology
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2023-04-06T18:24:26Z
dc.date.available.fl_str_mv 2023-04-06T18:24:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv KRETLI, Antoniana U. et al. The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 8, p. 1033-1042, Nov. 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57704
dc.identifier.issn.en_US.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762001000800002
identifier_str_mv KRETLI, Antoniana U. et al. The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 8, p. 1033-1042, Nov. 2001.
0074-0276
10.1590/S0074-02762001000800002
url https://www.arca.fiocruz.br/handle/icict/57704
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/IOC
publisher.none.fl_str_mv Fiocruz/IOC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/57704/2/Krettli_Antoniana_etal_IRR_2001.pdf
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