Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis

Detalhes bibliográficos
Autor(a) principal: Ferreras,Ana
Data de Publicação: 2002
Outros Autores: Triana,Ledia, Sánchez,Erlinda, Herrera,Flor
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000300018
Resumo: A cell-free system from Plasmodium falciparum able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. The antimalarial drugs did not inhibit the incorporation of [³H] methionine into parasite proteins even at concentrations higher than the ones found to strongly inhibit the parasite growth. Results clearly indicate that these compounds do not have a direct effect on protein synthesis activity of P. falciparum coded by endogenous mRNA.
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spelling Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein SynthesisPlasmodium falciparumprotein synthesiscell free translationantimalarial drugsA cell-free system from Plasmodium falciparum able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. The antimalarial drugs did not inhibit the incorporation of [³H] methionine into parasite proteins even at concentrations higher than the ones found to strongly inhibit the parasite growth. Results clearly indicate that these compounds do not have a direct effect on protein synthesis activity of P. falciparum coded by endogenous mRNA.Instituto Oswaldo Cruz, Ministério da Saúde2002-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000300018Memórias do Instituto Oswaldo Cruz v.97 n.3 2002reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762002000300018info:eu-repo/semantics/openAccessFerreras,AnaTriana,LediaSánchez,ErlindaHerrera,Floreng2020-04-25T17:48:46Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:11:03.042Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis
title Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis
spellingShingle Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis
Ferreras,Ana
Plasmodium falciparum
protein synthesis
cell free translation
antimalarial drugs
title_short Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis
title_full Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis
title_fullStr Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis
title_full_unstemmed Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis
title_sort Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis
author Ferreras,Ana
author_facet Ferreras,Ana
Triana,Ledia
Sánchez,Erlinda
Herrera,Flor
author_role author
author2 Triana,Ledia
Sánchez,Erlinda
Herrera,Flor
author2_role author
author
author
dc.contributor.author.fl_str_mv Ferreras,Ana
Triana,Ledia
Sánchez,Erlinda
Herrera,Flor
dc.subject.por.fl_str_mv Plasmodium falciparum
protein synthesis
cell free translation
antimalarial drugs
topic Plasmodium falciparum
protein synthesis
cell free translation
antimalarial drugs
dc.description.none.fl_txt_mv A cell-free system from Plasmodium falciparum able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. The antimalarial drugs did not inhibit the incorporation of [³H] methionine into parasite proteins even at concentrations higher than the ones found to strongly inhibit the parasite growth. Results clearly indicate that these compounds do not have a direct effect on protein synthesis activity of P. falciparum coded by endogenous mRNA.
description A cell-free system from Plasmodium falciparum able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. The antimalarial drugs did not inhibit the incorporation of [³H] methionine into parasite proteins even at concentrations higher than the ones found to strongly inhibit the parasite growth. Results clearly indicate that these compounds do not have a direct effect on protein synthesis activity of P. falciparum coded by endogenous mRNA.
publishDate 2002
dc.date.none.fl_str_mv 2002-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000300018
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000300018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762002000300018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.97 n.3 2002
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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