Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28806 |
Resumo: | Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Torres, Thiago S.Harrison, Linda J.La Rosa, Alberto M.Cardoso, Sandra W.Zheng, LuNgongondo, McNeilSome, Fatma F.Lalloo, Umesh G.Mwelase, ThandoCollier, Ann C.Hughes, Michael D.2018-09-14T18:17:13Z2018-09-14T18:17:13Z2018TORRES, Thiago S. et al. Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women. AIDS, p. 1-32, 2018.0269-9370https://www.arca.fiocruz.br/handle/icict/2880610.1097/QAD.0000000000001738enghttps://www.arca.fiocruz.br/handle/icict/57161Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCenter for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA.Asociación Civil Impacta Salud y Educación, Lima, Peru.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA.Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA / UNC Project Lilongwe, Malawi.AMPATH at Moi University Teaching Hospital, Eldoret, Kenya.Durban Adult HIV CRS, South Africa.Wits Health Consortium Department of Medicine, University of Witwatersrand, Johannesburg, South Africa.Department of Medicine, University of Washington, Seattle, WA, USA.Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA.OBJECTIVE: We evaluated improvement of quality of life (QoL) after one year of secondline antiretroviral therapy (ART) use in resource-limited settings (RLS) among adult men and women, comparing two randomized treatment arms. DESIGN: ACTG A5273 was a randomized clinical trial of second-line ART comparing lopinavir/ritonavir (LPV/r) + raltegravir (RAL) with LPV/r + nucleos(t)ide reverse transcriptase inhibitors (NRTIs) in participants failing a non-nucleoside reverse transcriptase inhibitor (NNRTI)-containing regimen at 15 sites in 9 RLS. Participants completed the ACTG SF-21 which has 8 QoL domains with a standard score ranging from 0 (worst) to 100 (best). METHODS: Differences in QoL by randomized arm, as well as by demographic and clinical variables, were evaluated by regression models for baseline and week 48 QoL scores fitted using the generalized estimating equations method (GEE). RESULTS: 512 individuals (49% male, median age 39 years) were included. 512 and 492 participants had QoL assessments at baseline and week 48, respectively. QoL improved significantly from week 0 to 48 (p<0.001 for all domains). There was no significant difference between treatment arms for any domain. Individuals with higher VL and lower CD4 at baseline had lower mean QoL at baseline but larger improvements such that mean QoL was similar at week 48. CONCLUSIONS: Improvements in QoL were similar after starting second-line ART of LPV/r combined with either RAL or NRTIs in RLS. QoL scores at baseline were lower among participants with worse disease status prior to starting second-line, but after one year similar QoL scores were achieved.Quality of lifeRaltegravirHIVSecond-line therapyAntiretroviral TherapyResource-limited settingsRandomized clinical trialinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/28806/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALQuality of life improvement in resource-limited settings_Thiago_Torres_INI_Lapclin-AIDS_2018.pdfQuality of life improvement in resource-limited 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| dc.title.pt_BR.fl_str_mv |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| title |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| spellingShingle |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women Torres, Thiago S. Quality of life Raltegravir HIV Second-line therapy Antiretroviral Therapy Resource-limited settings Randomized clinical trial |
| title_short |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| title_full |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| title_fullStr |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| title_full_unstemmed |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| title_sort |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| author |
Torres, Thiago S. |
| author_facet |
Torres, Thiago S. Harrison, Linda J. La Rosa, Alberto M. Cardoso, Sandra W. Zheng, Lu Ngongondo, McNeil Some, Fatma F. Lalloo, Umesh G. Mwelase, Thando Collier, Ann C. Hughes, Michael D. |
| author_role |
author |
| author2 |
Harrison, Linda J. La Rosa, Alberto M. Cardoso, Sandra W. Zheng, Lu Ngongondo, McNeil Some, Fatma F. Lalloo, Umesh G. Mwelase, Thando Collier, Ann C. Hughes, Michael D. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Torres, Thiago S. Harrison, Linda J. La Rosa, Alberto M. Cardoso, Sandra W. Zheng, Lu Ngongondo, McNeil Some, Fatma F. Lalloo, Umesh G. Mwelase, Thando Collier, Ann C. Hughes, Michael D. |
| dc.subject.en.pt_BR.fl_str_mv |
Quality of life Raltegravir HIV Second-line therapy Antiretroviral Therapy Resource-limited settings Randomized clinical trial |
| topic |
Quality of life Raltegravir HIV Second-line therapy Antiretroviral Therapy Resource-limited settings Randomized clinical trial |
| description |
Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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2018 |
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2018-09-14T18:17:13Z |
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2018-09-14T18:17:13Z |
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2018 |
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TORRES, Thiago S. et al. Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women. AIDS, p. 1-32, 2018. |
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https://www.arca.fiocruz.br/handle/icict/28806 |
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0269-9370 |
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10.1097/QAD.0000000000001738 |
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TORRES, Thiago S. et al. Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women. AIDS, p. 1-32, 2018. 0269-9370 10.1097/QAD.0000000000001738 |
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