Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57161 |
Resumo: | Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Torres, Thiago S.Harrison, Linda J.La Rosa, Alberto M.Cardoso, Sandra W.Zheng, LuNgongondo, McNeilSome, Fatma F.Lalloo, Umesh G.Mwelase, ThandoCollier, Ann C.Hughes, Michael D.2023-03-01T02:39:28Z2023-03-01T02:39:28Z2018TORRES, Thiago S. et al. Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women. AIDS, v. 32, n. 5, p. 583-593, 2018.0269-9370https://www.arca.fiocruz.br/handle/icict/5716110.1097/QAD.0000000000001738engWolters Kluwer Healthhttps://www.arca.fiocruz.br/handle/icict/28806Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCenter for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA.Asociación Civil Impacta Salud y Educación, Lima, Peru.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA.Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA / UNC Project Lilongwe, Malawi.AMPATH at Moi University Teaching Hospital, Eldoret, Kenya.Durban Adult HIV CRS, South Africa.Wits Health Consortium Department of Medicine, University of Witwatersrand, Johannesburg, South Africa.Department of Medicine, University of Washington, Seattle, WA, USA.Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA.Objective: We evaluated improvement of quality of life (QoL) after 1 year of second-line antiretroviral therapy (ART) use in resource-limited settings (RLS) among adult men and women, comparing two randomized treatment arms. Design: The AIDS Clinical Trial Group A5273 was a randomized clinical trial of second-line ART comparing lopinavir/ritonavir (LPV/r) + raltegravir with LPV/r + nucleos(t)ide reverse transcriptase inhibitors (NRTIs) in participants failing a non-NRTI-containing regimen at 15 sites in nine RLS. Participants completed the AIDS Clinical Trial Group short-form-21 which has eight QoL domains with a standard score ranging from 0 (worst) to 100 (best). Methods: Differences in QoL by randomized arm, as well as by demographic and clinical variables, were evaluated by regression models for baseline and week 48 QoL scores fitted using the generalized estimating equations method. Results: A total of 512 individuals (49% men, median age 39 years) were included. A total of 512 and 492 participants had QoL assessments at baseline and week 48, respectively. QoL improved significantly from baseline to week 48 (P < 0.001 for all domains). There was no significant difference between treatment arms for any domain. Individuals with higher viral load and lower CD4 cell count at baseline had lower mean QoL at baseline but larger improvements such that mean QoL was similar at week 48. Conclusion: Improvements in QoL were similar after starting second-line ART of LPV/r combined with either raltegravir or NRTIs in RLS. QoL scores at baseline were lower among participants with worse disease status prior to starting second-line, but after 1 year similar QoL scores were achieved.Quality of lifeRaltegravirHIVSecond-line therapyAntiretroviral TherapyResource-limited settingsRandomized clinical trialinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Torres_Thiago_etal_INI_2018_ARTIGO FINAL.pdfve_Torres_Thiago_etal_INI_2018_ARTIGO FINAL.pdfapplication/pdf467382https://www.arca.fiocruz.br/bitstream/icict/57161/2/ve_Torres_Thiago_etal_INI_2018_ARTIGO%20FINAL.pdfb2e25459fdc195a8d3ce45704cdbc097MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57161/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/571612023-02-28 23:39:29.311oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-01T02:39:29Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| title |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| spellingShingle |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women Torres, Thiago S. Quality of life Raltegravir HIV Second-line therapy Antiretroviral Therapy Resource-limited settings Randomized clinical trial |
| title_short |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| title_full |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| title_fullStr |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| title_full_unstemmed |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| title_sort |
Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women |
| author |
Torres, Thiago S. |
| author_facet |
Torres, Thiago S. Harrison, Linda J. La Rosa, Alberto M. Cardoso, Sandra W. Zheng, Lu Ngongondo, McNeil Some, Fatma F. Lalloo, Umesh G. Mwelase, Thando Collier, Ann C. Hughes, Michael D. |
| author_role |
author |
| author2 |
Harrison, Linda J. La Rosa, Alberto M. Cardoso, Sandra W. Zheng, Lu Ngongondo, McNeil Some, Fatma F. Lalloo, Umesh G. Mwelase, Thando Collier, Ann C. Hughes, Michael D. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Torres, Thiago S. Harrison, Linda J. La Rosa, Alberto M. Cardoso, Sandra W. Zheng, Lu Ngongondo, McNeil Some, Fatma F. Lalloo, Umesh G. Mwelase, Thando Collier, Ann C. Hughes, Michael D. |
| dc.subject.en.en_US.fl_str_mv |
Quality of life Raltegravir HIV Second-line therapy Antiretroviral Therapy Resource-limited settings Randomized clinical trial |
| topic |
Quality of life Raltegravir HIV Second-line therapy Antiretroviral Therapy Resource-limited settings Randomized clinical trial |
| description |
Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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2018 |
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2018 |
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2023-03-01T02:39:28Z |
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2023-03-01T02:39:28Z |
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TORRES, Thiago S. et al. Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women. AIDS, v. 32, n. 5, p. 583-593, 2018. |
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https://www.arca.fiocruz.br/handle/icict/57161 |
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0269-9370 |
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10.1097/QAD.0000000000001738 |
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TORRES, Thiago S. et al. Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women. AIDS, v. 32, n. 5, p. 583-593, 2018. 0269-9370 10.1097/QAD.0000000000001738 |
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Wolters Kluwer Health |
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