Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studies
| Autor(a) principal: | |
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| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/33840 |
Resumo: | CIC INSERM 1424. Cayenne, French Guiana / Centre Hospitalier Andrée Rosemon. Cayenne, French Guiana. |
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Nacher, MathieuBlanchet, DenisBongomin, FelixChakrabarti, ArunalokeCouppié, PierreDemar, MagalieDenning, David W.Djossou, FélixEpelboin, LoïcGovender, NeleshLeitão, TerezinhaMac Donald, SigridMandengue, ChristineSilva, Silvia Helena Marques daOladele, RitaPanizo, Maria MercedesPasqualotto, AlessandroRamos, RuthSwaminathan, SubramanianRodriguez-Tudela, Juan LuisVreden, StephenZancopé-Oliveira, RoselyAdenis, Antoine2019-07-04T15:11:22Z2019-07-04T15:11:22Z2018NACHER, Mathieu et al. Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studies. Plos Neglected Tropical Diseases, p. 1-12, Oct. 2018.1935-2727https://www.arca.fiocruz.br/handle/icict/3384010.1371/journal.pntd.00068021935-2735engPublic Library of ScienceHistoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCIC INSERM 1424. Cayenne, French Guiana / Centre Hospitalier Andrée Rosemon. Cayenne, French Guiana.Centre Hospitalier Andrée Rosemon. Laboratoire de Parasitologie Mycologie. Cayenne, French Guiana.Global Fund for Fungal Infections. Geneva, Switzerland.Postgraduate Institute of Medical Education & Research. Chandigarh, India.Centre Hospitalier Andrée Rosemon. Service de Dermatologie Vénéréologie. Cayenne, French Guiana.Centre Hospitalier Andrée Rosemon. Laboratoire de Parasitologie Mycologie. Cayenne, French Guiana.Global Fund for Fungal Infections. Geneva, Switzerland.Centre Hospitalier Andrée Rosemon. Service des maladies infectieuses et tropicales. Cayenne, French Guiana.Centre Hospitalier Andrée Rosemon. Service des maladies infectieuses et tropicales. Cayenne, French Guiana.Centre for Opportunistic, Tropical and Hospital Infections. Johannesburg, South Africa / National Institute for Communicable Diseases. Johannesburg, South Africa.Universidade Federal do Ceará. Fortaleza, CE, Brasil.Scientific Research Center Suriname. Academic hospital Paramaribo. Paramaribo, Suriname.Université des Montagnes. Bangangté, Cameroon.Evandro Chagas Institute. Belém, PA, Brazil.University of Lagos. College of Medicine. Lagos, Nigeria.Instituto Nacional de Higiene "Rafael Rangel". Caracas, Venezuela.Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre, RS, Brasil.National Care and Treatment Center. Georgetown, Guyana.Global Hospitals. Chennai, India.Global Fund for Fungal Infections. Geneva, Switzerland.Scientific Research Center Suriname. Academic hospital Paramaribo. Paramaribo, Suriname.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Centre Hospitalier Andrée Rosemon. Service des maladies infectieuses et tropicales. Cayenne, French Guiana.Introduction: Disseminated histoplasmosis, a disease that often resembles and is mistaken for tuberculosis, is a major cause of death in patients with advanced HIV disease. Histoplasma antigen detection tests are an important addition to the diagnostic arsenal for patients with advanced HIV disease and should be considered for inclusion on the World Health Organization Essential Diagnostics List. Objective: Our objective was to systematically review the literature to evaluate the diagnostic accuracy of Histoplasma antigen tests in the context of advanced HIV disease, with a focus on lowand middle-income countries. Methods: A systematic review of the published literature extracted data on comparator groups, type of histoplasmosis, HIV status, performance results, patient numbers, whether patients were consecutively enrolled or if the study used biobank samples. PubMed, Scopus, Lilacs and Scielo databases were searched for published articles between 1981 and 2018. There was no language restriction. Results: Of 1327 screened abstracts we included a total of 16 studies in humans for further analysis. Most studies included used a heterogeneousgroup of patients, often without HIV or mixing HIV and non HIV patients, with disseminated or non-disseminated forms of histoplasmosis. Six studies did not systematically use mycologically confirmed cases as a gold standard but compared antigen detection tests against another antigen detection test. Patient numbers were generally small (19–65) in individual studies and, in most (7/10), no confidence intervals were given. The post test probability of a positive or negative test were good suggesting that this non invasive diagnostic tool would be very useful for HIV care givers at the level of reference hospitals or hospitals with the infrastructure to perform ELISA tests. The first results evaluating point of care antigen detection tests using a lateral flow assay were promising with high sensitivity and specificity. Conclusions: Antigen detection tests are promising tools to improve detection of and ultimately reduce the burden of histoplasmosis mortality in patients with advanced HIV disease.Histoplasma capsulatumHIV diseaseHistoplasma antigen testsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/33840/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Nacher_Mathieu_etal_INI_2018.pdfve_Nacher_Mathieu_etal_INI_2018.pdfapplication/pdf910075https://www.arca.fiocruz.br/bitstream/icict/33840/2/ve_Nacher_Mathieu_etal_INI_2018.pdf824d0b6cb27eb74e9bfea7367b22c2feMD52TEXTve_Nacher_Mathieu_etal_INI_2018.pdf.txtve_Nacher_Mathieu_etal_INI_2018.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studies |
| title |
Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studies |
| spellingShingle |
Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studies Nacher, Mathieu Histoplasma capsulatum HIV disease Histoplasma antigen tests |
| title_short |
Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studies |
| title_full |
Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studies |
| title_fullStr |
Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studies |
| title_full_unstemmed |
Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studies |
| title_sort |
Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studies |
| author |
Nacher, Mathieu |
| author_facet |
Nacher, Mathieu Blanchet, Denis Bongomin, Felix Chakrabarti, Arunaloke Couppié, Pierre Demar, Magalie Denning, David W. Djossou, Félix Epelboin, Loïc Govender, Nelesh Leitão, Terezinha Mac Donald, Sigrid Mandengue, Christine Silva, Silvia Helena Marques da Oladele, Rita Panizo, Maria Mercedes Pasqualotto, Alessandro Ramos, Ruth Swaminathan, Subramanian Rodriguez-Tudela, Juan Luis Vreden, Stephen Zancopé-Oliveira, Rosely Adenis, Antoine |
| author_role |
author |
| author2 |
Blanchet, Denis Bongomin, Felix Chakrabarti, Arunaloke Couppié, Pierre Demar, Magalie Denning, David W. Djossou, Félix Epelboin, Loïc Govender, Nelesh Leitão, Terezinha Mac Donald, Sigrid Mandengue, Christine Silva, Silvia Helena Marques da Oladele, Rita Panizo, Maria Mercedes Pasqualotto, Alessandro Ramos, Ruth Swaminathan, Subramanian Rodriguez-Tudela, Juan Luis Vreden, Stephen Zancopé-Oliveira, Rosely Adenis, Antoine |
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author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Nacher, Mathieu Blanchet, Denis Bongomin, Felix Chakrabarti, Arunaloke Couppié, Pierre Demar, Magalie Denning, David W. Djossou, Félix Epelboin, Loïc Govender, Nelesh Leitão, Terezinha Mac Donald, Sigrid Mandengue, Christine Silva, Silvia Helena Marques da Oladele, Rita Panizo, Maria Mercedes Pasqualotto, Alessandro Ramos, Ruth Swaminathan, Subramanian Rodriguez-Tudela, Juan Luis Vreden, Stephen Zancopé-Oliveira, Rosely Adenis, Antoine |
| dc.subject.en.pt_BR.fl_str_mv |
Histoplasma capsulatum HIV disease Histoplasma antigen tests |
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Histoplasma capsulatum HIV disease Histoplasma antigen tests |
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CIC INSERM 1424. Cayenne, French Guiana / Centre Hospitalier Andrée Rosemon. Cayenne, French Guiana. |
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2018 |
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2018 |
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2019-07-04T15:11:22Z |
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2019-07-04T15:11:22Z |
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NACHER, Mathieu et al. Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studies. Plos Neglected Tropical Diseases, p. 1-12, Oct. 2018. |
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https://www.arca.fiocruz.br/handle/icict/33840 |
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1935-2727 |
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10.1371/journal.pntd.0006802 |
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1935-2735 |
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NACHER, Mathieu et al. Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: a systematic review of diagnostic accuracy studies. Plos Neglected Tropical Diseases, p. 1-12, Oct. 2018. 1935-2727 10.1371/journal.pntd.0006802 1935-2735 |
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Public Library of Science |
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