Development and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samples

Detalhes bibliográficos
Autor(a) principal: Koishi, Andrea Cristine
Data de Publicação: 2016
Outros Autores: Aoki, Mateus Nóbrega, Jorge, Taissa Ricciardi, Suzukawa, Andréia Akemi, Zanluca, Camila, Levis, Silvana, Santos, Claudia Nunes Duarte dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16154
Resumo: CNPq, Fundação Araucária, CAPES, PROBIO
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spelling Koishi, Andrea CristineAoki, Mateus NóbregaJorge, Taissa RicciardiSuzukawa, Andréia AkemiZanluca, CamilaLevis, SilvanaSantos, Claudia Nunes Duarte dos2016-10-07T18:45:18Z2016-10-07T18:45:18Z2016KOISHI, A., C., et al. Development and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samples. Diagn Microbiol Infect Dis., v. 85, n. 3, p. 323-327, July 2016.0732-8893https://www.arca.fiocruz.br/handle/icict/1615410.1016/j.diagmicrobio.2016.04.010CNPq, Fundação Araucária, CAPES, PROBIOFundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.Instituto Nacional de Enfermedades Virales Humanas Dr. J. I. Maiztegui, Pergamino, Argentina.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.Hantaviruses are etiologic agents of a zoonotic disease transmitted mainly from wild rodents to humans, causing Hemorrhagic Fever with Renal Syndrome in Eurasia and the Hantavirus Cardiopulmonary Syndrome in the Americas (HCPS), reaching a lethality rate of 40% in Brazil. Hantavirus diagnostic and seroprevalence are often based on the presence of IgM and IgG antibodies against the virus. Here we propose a rapid test assay able to identify hantavirus antibodies with sensibility and specificity similar to ELISA assays. We analyzed five groups of samples, including healthy human population and small mammals of endemic areas, suspected cases of HCPS, patients with non-related infections and a serum panel from a different geographical region. The test presented good rates of sensibility (87-100%) and specificity (97-100%) for all groups, being a promising tool suitable for both rodent and human hantavirus epidemiological surveys.engMark HolodniyDevelopment and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samplesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHantavirusHantavirus cardiopulmonary syndrome (HCPS)Rapid testRodentsHuman seroprevalenceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83074https://www.arca.fiocruz.br/bitstream/icict/16154/1/license.txt0271fb68963c017aa933c7aff60379f4MD51ORIGINALDevelopment and validation of a point-of-care test.pdfDevelopment and validation of a point-of-care 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dc.title.pt_BR.fl_str_mv Development and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samples
title Development and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samples
spellingShingle Development and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samples
Koishi, Andrea Cristine
Hantavirus
Hantavirus cardiopulmonary syndrome (HCPS)
Rapid test
Rodents
Human seroprevalence
title_short Development and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samples
title_full Development and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samples
title_fullStr Development and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samples
title_full_unstemmed Development and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samples
title_sort Development and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samples
author Koishi, Andrea Cristine
author_facet Koishi, Andrea Cristine
Aoki, Mateus Nóbrega
Jorge, Taissa Ricciardi
Suzukawa, Andréia Akemi
Zanluca, Camila
Levis, Silvana
Santos, Claudia Nunes Duarte dos
author_role author
author2 Aoki, Mateus Nóbrega
Jorge, Taissa Ricciardi
Suzukawa, Andréia Akemi
Zanluca, Camila
Levis, Silvana
Santos, Claudia Nunes Duarte dos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Koishi, Andrea Cristine
Aoki, Mateus Nóbrega
Jorge, Taissa Ricciardi
Suzukawa, Andréia Akemi
Zanluca, Camila
Levis, Silvana
Santos, Claudia Nunes Duarte dos
dc.subject.en.pt_BR.fl_str_mv Hantavirus
Hantavirus cardiopulmonary syndrome (HCPS)
Rapid test
Rodents
Human seroprevalence
topic Hantavirus
Hantavirus cardiopulmonary syndrome (HCPS)
Rapid test
Rodents
Human seroprevalence
description CNPq, Fundação Araucária, CAPES, PROBIO
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-10-07T18:45:18Z
dc.date.available.fl_str_mv 2016-10-07T18:45:18Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KOISHI, A., C., et al. Development and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samples. Diagn Microbiol Infect Dis., v. 85, n. 3, p. 323-327, July 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16154
dc.identifier.issn.pt_BR.fl_str_mv 0732-8893
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.diagmicrobio.2016.04.010
identifier_str_mv KOISHI, A., C., et al. Development and validation of a point-of-care test for detecting hantavirus antibodies in human and rodent samples. Diagn Microbiol Infect Dis., v. 85, n. 3, p. 323-327, July 2016.
0732-8893
10.1016/j.diagmicrobio.2016.04.010
url https://www.arca.fiocruz.br/handle/icict/16154
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mark Holodniy
publisher.none.fl_str_mv Mark Holodniy
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/16154/1/license.txt
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