Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/24957 |
Resumo: | Gonçalo Moniz Institute at the Oswaldo Cruz Foundation (IGM-FIOCRUZ – Bahia - Brazil) (CAAE 08452913.9.0000.0040). |
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Aleluia, Milena MagalhãesGuarda, Caroline Conceição daSantiago, Rayra PereiraFonseca, Teresa Cristina CardosoNeves, Fábia IdalinaSouza, Regiana Quinto deFarias, Larissa AlvesPimenta, Felipe AraújoFiuza, Luciana MagalhãesPitanga, Thassila NogueiraFerreira, Júnia Raquel DutraAdorno, Elisângela VitóriaCerqueira, Bruno Antonio VelosoGonçalves, Marilda de Souza2018-02-27T12:31:07Z2018-02-27T12:31:07Z2017ALELUIA, Milena Magalhães et al. Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia. Lipids in Health and Disease, v. 16, p. 1-9, 2017.1476-511Xhttps://www.arca.fiocruz.br/handle/icict/2495710.1186/s12944-017-0454-1Gonçalo Moniz Institute at the Oswaldo Cruz Foundation (IGM-FIOCRUZ – Bahia - Brazil) (CAAE 08452913.9.0000.0040).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Centro de Referência a Doença Falciforme de Itabuna. Itabuna, BA, Brasil / Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil.Centro de Referência a Doença Falciforme de Itabuna. Itabuna, BA, Brasil.Centro de Referência a Doença Falciforme de Itabuna. Itabuna, BA, Brasil / Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil.Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil.Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Estadual da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has been also associated to alterations in the lipid profile. This study aims to analyze hematological and biochemical parameters to provide knowledge about the SCA sub-phenotypes previously described and suggest a dyslipidemic sub-phenotype. Methods: A cross-sectional study was conducted from 2013 to 2014, and 99 SCA patients in steady state were enrolled. We assessed correlations and associations with hematological and biochemical data and investigated the co-inheritance of -α3.7Kb-thalassemia (-α3.7Kb-thal). Correlation analyses were performed using Spearman and Pearson coefficient. The median of quantitative variables between two groups was compared using t-test and Mann-Whitney. P-values <0.05 were considered statistically significant. Results: We found significant association of high lactate dehydrogenase levels with decreased red blood cell count and hematocrit as well as high levels of total and indirect bilirubin. SCA patients with low nitric oxide metabolites had high total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol and reduced very low-density cholesterol, triglycerides, direct bilirubin level and reticulocyte counts. In SCA patients with high-density lipoprotein cholesterol greater than 40 mg/dL, we observed increased red blood cell count, hemoglobin, hematocrit, and fetal hemoglobin and decreased nitric oxide metabolites levels. The presence of -α3.7Kb-thal was associated with high red blood cell count and low mean corpuscular volume, mean corpuscular hemoglobin, platelet count and total and indirect bilirubin levels. Conclusions: Our results provide additional information about the association between biomarkers and co-inheritance of -α3.7Kb-thal in SCA, and suggest the role of dyslipidemia and nitric oxide metabolites in the characterization of this sub-phenotype.engBioMed CentralSub-fenótipoAnemia falciformeSislipidemiaα-talassemiaSub-phenotypeSickle cell anemiaDyslipidemiaα-thalassemiaAssociation of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24957/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAleluia MM Association of classical markers .....pdfAleluia MM Association of classical markers 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| dc.title.pt_BR.fl_str_mv |
Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia |
| title |
Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia |
| spellingShingle |
Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia Aleluia, Milena Magalhães Sub-fenótipo Anemia falciforme Sislipidemia α-talassemia Sub-phenotype Sickle cell anemia Dyslipidemia α-thalassemia |
| title_short |
Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia |
| title_full |
Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia |
| title_fullStr |
Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia |
| title_full_unstemmed |
Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia |
| title_sort |
Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia |
| author |
Aleluia, Milena Magalhães |
| author_facet |
Aleluia, Milena Magalhães Guarda, Caroline Conceição da Santiago, Rayra Pereira Fonseca, Teresa Cristina Cardoso Neves, Fábia Idalina Souza, Regiana Quinto de Farias, Larissa Alves Pimenta, Felipe Araújo Fiuza, Luciana Magalhães Pitanga, Thassila Nogueira Ferreira, Júnia Raquel Dutra Adorno, Elisângela Vitória Cerqueira, Bruno Antonio Veloso Gonçalves, Marilda de Souza |
| author_role |
author |
| author2 |
Guarda, Caroline Conceição da Santiago, Rayra Pereira Fonseca, Teresa Cristina Cardoso Neves, Fábia Idalina Souza, Regiana Quinto de Farias, Larissa Alves Pimenta, Felipe Araújo Fiuza, Luciana Magalhães Pitanga, Thassila Nogueira Ferreira, Júnia Raquel Dutra Adorno, Elisângela Vitória Cerqueira, Bruno Antonio Veloso Gonçalves, Marilda de Souza |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Aleluia, Milena Magalhães Guarda, Caroline Conceição da Santiago, Rayra Pereira Fonseca, Teresa Cristina Cardoso Neves, Fábia Idalina Souza, Regiana Quinto de Farias, Larissa Alves Pimenta, Felipe Araújo Fiuza, Luciana Magalhães Pitanga, Thassila Nogueira Ferreira, Júnia Raquel Dutra Adorno, Elisângela Vitória Cerqueira, Bruno Antonio Veloso Gonçalves, Marilda de Souza |
| dc.subject.other.pt_BR.fl_str_mv |
Sub-fenótipo Anemia falciforme Sislipidemia α-talassemia |
| topic |
Sub-fenótipo Anemia falciforme Sislipidemia α-talassemia Sub-phenotype Sickle cell anemia Dyslipidemia α-thalassemia |
| dc.subject.en.pt_BR.fl_str_mv |
Sub-phenotype Sickle cell anemia Dyslipidemia α-thalassemia |
| description |
Gonçalo Moniz Institute at the Oswaldo Cruz Foundation (IGM-FIOCRUZ – Bahia - Brazil) (CAAE 08452913.9.0000.0040). |
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2017 |
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2017 |
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2018-02-27T12:31:07Z |
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2018-02-27T12:31:07Z |
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info:eu-repo/semantics/article |
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ALELUIA, Milena Magalhães et al. Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia. Lipids in Health and Disease, v. 16, p. 1-9, 2017. |
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https://www.arca.fiocruz.br/handle/icict/24957 |
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1476-511X |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s12944-017-0454-1 |
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ALELUIA, Milena Magalhães et al. Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia. Lipids in Health and Disease, v. 16, p. 1-9, 2017. 1476-511X 10.1186/s12944-017-0454-1 |
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BioMed Central |
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BioMed Central |
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