What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

Fouts, Derrick E; Matthias, Michael A; Adhikarla, Haritha; Adler, Ben; Santos, Luciane Amorim; Berg, Douglas E; Bulach, Dieter; Buschiazzo, Alejandro; Chang, Yung-Fu; Galloway, Renee L; Haake, David A; Haft, Daniel H; Hartskeerl, Rudy; Ko, Albert Icksang; Levett, Paul N; Matsunaga, James; Mechaly, Ariel E; Monk, Jonathan M; Nascimento, Ana Lúcia Tablet Oller do; Nelson, Karen E; Palsson, Bernhard; Peacock, Sharon J; Picardeau, Mathieu; Ricaldi, Jessica N; Thaipandungpanit, Janjira; Wunder Junior, Elsio Augusto; Yang, X Frank; Zhang, Jun-Jie; Vinetz, Joseph M

What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

Detalhes bibliográficos
Autor(a) principal:	Fouts, Derrick E
Data de Publicação:	2016
Outros Autores:	Matthias, Michael A, Adhikarla, Haritha, Adler, Ben, Santos, Luciane Amorim, Berg, Douglas E, Bulach, Dieter, Buschiazzo, Alejandro, Chang, Yung-Fu, Galloway, Renee L, Haake, David A, Haft, Daniel H, Hartskeerl, Rudy, Ko, Albert Icksang, Levett, Paul N, Matsunaga, James, Mechaly, Ariel E, Monk, Jonathan M, Nascimento, Ana Lúcia Tablet Oller do, Nelson, Karen E, Palsson, Bernhard, Peacock, Sharon J, Picardeau, Mathieu, Ricaldi, Jessica N, Thaipandungpanit, Janjira, Wunder Junior, Elsio Augusto, Yang, X Frank, Zhang, Jun-Jie, Vinetz, Joseph M
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/17896
Resumo:	National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services

Metadados do item

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Fouts, Derrick EMatthias, Michael AAdhikarla, HarithaAdler, BenSantos, Luciane AmorimBerg, Douglas EBulach, DieterBuschiazzo, AlejandroChang, Yung-FuGalloway, Renee LHaake, David AHaft, Daniel HHartskeerl, RudyKo, Albert IcksangLevett, Paul NMatsunaga, JamesMechaly, Ariel EMonk, Jonathan MNascimento, Ana Lúcia Tablet Oller doNelson, Karen EPalsson, BernhardPeacock, Sharon JPicardeau, MathieuRicaldi, Jessica NThaipandungpanit, JanjiraWunder Junior, Elsio AugustoYang, X FrankZhang, Jun-JieVinetz, Joseph M2017-02-23T16:47:12Z2017-02-23T16:47:12Z2016FOUTS, D. E. et al. What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. Plos Neglected Tropical Diseases, v. 10, n. 2, e0004403, 2016.1935-2727https://www.arca.fiocruz.br/handle/icict/1789610.1371/journal.pntd.0004403National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human ServicesJ. Craig Venter Institute. Rockville, Maryland, USAUniversity of California San Diego School of Medicine. Division of Infectious Diseases. Department of Medicine. La Jolla, California, USAYale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USAMonash University. Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics. Department of Microbiology. Clayton, AustraliaYale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of California San Diego School of Medicine. Division of Infectious Diseases. Department of Medicine. La Jolla, California, USAMonash University. Victorian Bioinformatics Consortium. Clayton, Victoria, AustraliaInstitut Pasteur de Montevideo. Laboratory of Molecular and Structural Microbiology. Montevideo, Uruguay / Institut Pasteur. Department of Structural Biology and Chemistry. Paris, FranceCornell University. College of Veterinary Medicine. Department of Population Medicine & Diagnostic Sciences. Ithaca, New York, USACenters for Disease Control and Prevention (DHHS, CDC, OID, NCEZID, DHCPP, BSPB). Atlanta, Georgia, USAVA Greater Los Angeles Healthcare System. Los Angeles California, USA / David Geffen School of Medicine at UCLA. Los Angeles, California, USAJ. Craig Venter Institute. Rockville, Maryland, USAWHO/FAO/OIE and National Collaborating Centre for Reference and Research on Leptospirosis. Royal Tropical Institute (KIT). KIT Biomedical Research. Amsterdam, The NetherlandsYale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilGovernment of Saskatchewan. Disease Control Laboratory Regina. CanadaVA Greater Los Angeles Healthcare System. Los Angeles California, USA / David Geffen School of Medicine at UCLA. Los Angeles, California, USAInstitut Pasteur de Montevideo. Laboratory of Molecular and Structural Microbiology. Montevideo, UruguayUniversity of California. Department of Bioengineering. San Diego, La Jolla, California, USAInstituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil / Instituto de Ciências Biomédicas USP. Programa Interunidades em Biotecnologia. São Paulo, SP, BrasilJ. Craig Venter Institute. Rockville, Maryland, USAUniversity of California. Department of Bioengineering. San Diego, La Jolla, California, USAUniversity of Cambridge. Department of Medicine. Cambridge, United KingdomInstitut Pasteur. Biology of Spirochetes Unit. National Reference Centre and WHO Collaborating Center for Leptospirosis. Paris, FranceUniversidd Peruana Cayetano Heredia. Facultad de Medicina Alberto Hurtado. Instituto de Medicina Tropical Alexander von Humboldt. Lima, PeruMahidol University. Faculty of Tropical Medicine. Bangkok, ThailandYale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilIndiana University School of Medicine. Department of Microbiology and Immunology. Indianapolis, Indiana, USAIndiana University School of Medicine. Department of Microbiology and Immunology. Indianapolis, Indiana, USAUniversity of California San Diego School of Medicine. Division of Infectious Diseases. Department of Medicine. La Jolla, California, USA / Universidd Peruana Cayetano Heredia. Facultad de Medicina Alberto Hurtado. Instituto de Medicina Tropical Alexander von Humboldt. Lima, Peru / Universidad Peruana Cayetano Heredia. Instituto de Medicina “Alexander von Humboldt,”. Lima, PeruLeptospirosis, caused by spirochetes of the genus Leptospira, is a globally widespread, neglected and emerging zoonotic disease. While whole genome analysis of individual pathogenic, intermediately pathogenic and saprophytic Leptospira species has been reported, comprehensive cross-species genomic comparison of all known species of infectious and non-infectious Leptospira, with the goal of identifying genes related to pathogenesis and mammalian host adaptation, remains a key gap in the field. Infectious Leptospira, comprised of pathogenic and intermediately pathogenic Leptospira, evolutionarily diverged from non-infectious, saprophytic Leptospira, as demonstrated by the following computational biology analyses: 1) the definitive taxonomy and evolutionary relatedness among all known Leptospira species; 2) genomically-predicted metabolic reconstructions that indicate novel adaptation of infectious Leptospira to mammals, including sialic acid biosynthesis, pathogen-specific porphyrin metabolism and the first-time demonstration of cobalamin (B12) autotrophy as a bacterial virulence factor; 3) CRISPR/Cas systems demonstrated only to be present in pathogenic Leptospira, suggesting a potential mechanism for this clade's refractoriness to gene targeting; 4) finding Leptospira pathogen-specific specialized protein secretion systems; 5) novel virulence-related genes/gene families such as the Virulence Modifying (VM) (PF07598 paralogs) proteins and pathogen-specific adhesins; 6) discovery of novel, pathogen-specific protein modification and secretion mechanisms including unique lipoprotein signal peptide motifs, Sec-independent twin arginine protein secretion motifs, and the absence of certain canonical signal recognition particle proteins from all Leptospira; and 7) and demonstration of infectious Leptospira-specific signal-responsive gene expression, motility and chemotaxis systems. By identifying large scale changes in infectious (pathogenic and intermediately pathogenic) vs. non-infectious Leptospira, this work provides new insights into the evolution of a genus of bacterial pathogens. This work will be a comprehensive roadmap for understanding leptospirosis pathogenesis. More generally, it provides new insights into mechanisms by which bacterial pathogens adapt to mammalian hosts.engPublic Library of ScienceLeptospiraLeptospiroseEvolução molecularFilogeniaAnimaisVirulênciaGenoma bacterianoLeptospiraLeptospirosisEvolution, molecularPhylogenyAnimalsVirulenceGenome, bacterialWhat Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospirainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17896/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFouts DE What makes a bacterial....pdfFouts DE What makes a 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dc.title.pt_BR.fl_str_mv	What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
title	What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
spellingShingle	What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira Fouts, Derrick E Leptospira Leptospirose Evolução molecular Filogenia Animais Virulência Genoma bacteriano Leptospira Leptospirosis Evolution, molecular Phylogeny Animals Virulence Genome, bacterial
title_short	What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
title_full	What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
title_fullStr	What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
title_full_unstemmed	What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
title_sort	What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
author	Fouts, Derrick E
author_facet	Fouts, Derrick E Matthias, Michael A Adhikarla, Haritha Adler, Ben Santos, Luciane Amorim Berg, Douglas E Bulach, Dieter Buschiazzo, Alejandro Chang, Yung-Fu Galloway, Renee L Haake, David A Haft, Daniel H Hartskeerl, Rudy Ko, Albert Icksang Levett, Paul N Matsunaga, James Mechaly, Ariel E Monk, Jonathan M Nascimento, Ana Lúcia Tablet Oller do Nelson, Karen E Palsson, Bernhard Peacock, Sharon J Picardeau, Mathieu Ricaldi, Jessica N Thaipandungpanit, Janjira Wunder Junior, Elsio Augusto Yang, X Frank Zhang, Jun-Jie Vinetz, Joseph M
author_role	author
author2	Matthias, Michael A Adhikarla, Haritha Adler, Ben Santos, Luciane Amorim Berg, Douglas E Bulach, Dieter Buschiazzo, Alejandro Chang, Yung-Fu Galloway, Renee L Haake, David A Haft, Daniel H Hartskeerl, Rudy Ko, Albert Icksang Levett, Paul N Matsunaga, James Mechaly, Ariel E Monk, Jonathan M Nascimento, Ana Lúcia Tablet Oller do Nelson, Karen E Palsson, Bernhard Peacock, Sharon J Picardeau, Mathieu Ricaldi, Jessica N Thaipandungpanit, Janjira Wunder Junior, Elsio Augusto Yang, X Frank Zhang, Jun-Jie Vinetz, Joseph M
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Fouts, Derrick E Matthias, Michael A Adhikarla, Haritha Adler, Ben Santos, Luciane Amorim Berg, Douglas E Bulach, Dieter Buschiazzo, Alejandro Chang, Yung-Fu Galloway, Renee L Haake, David A Haft, Daniel H Hartskeerl, Rudy Ko, Albert Icksang Levett, Paul N Matsunaga, James Mechaly, Ariel E Monk, Jonathan M Nascimento, Ana Lúcia Tablet Oller do Nelson, Karen E Palsson, Bernhard Peacock, Sharon J Picardeau, Mathieu Ricaldi, Jessica N Thaipandungpanit, Janjira Wunder Junior, Elsio Augusto Yang, X Frank Zhang, Jun-Jie Vinetz, Joseph M
dc.subject.other.pt_BR.fl_str_mv	Leptospira Leptospirose Evolução molecular Filogenia Animais Virulência Genoma bacteriano
topic	Leptospira Leptospirose Evolução molecular Filogenia Animais Virulência Genoma bacteriano Leptospira Leptospirosis Evolution, molecular Phylogeny Animals Virulence Genome, bacterial
dc.subject.en.pt_BR.fl_str_mv	Leptospira Leptospirosis Evolution, molecular Phylogeny Animals Virulence Genome, bacterial
description	National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services
publishDate	2016
dc.date.issued.fl_str_mv	2016
dc.date.accessioned.fl_str_mv	2017-02-23T16:47:12Z
dc.date.available.fl_str_mv	2017-02-23T16:47:12Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	FOUTS, D. E. et al. What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. Plos Neglected Tropical Diseases, v. 10, n. 2, e0004403, 2016.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/17896
dc.identifier.issn.pt_BR.fl_str_mv	1935-2727
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pntd.0004403
identifier_str_mv	FOUTS, D. E. et al. What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. Plos Neglected Tropical Diseases, v. 10, n. 2, e0004403, 2016. 1935-2727 10.1371/journal.pntd.0004403
url	https://www.arca.fiocruz.br/handle/icict/17896
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

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