Leishmaniases diagnosis: an update on the use of immunological and molecular tools
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23170 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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Paiva-Cavalcanti, Milena deMorais, Rayana Carla Silva dePessoa-E-Silva, RômuloTrajano-Silva, Lays Adrianne MendonçaGonçalves-de-Albuquerque, Suênia da CunhaTavares, Diego de Hollanda CavalcantiBrelaz-de-Castro, Maria Carolina AcciolySilva, Rafael de Freitas E.Pereira, Valéria Rêgo Alves2017-11-14T13:55:45Z2017-11-14T13:55:45Z2015DE PAIVA-CAVALCANTI, M. et al. Leishmaniases diagnosis: an update on the use of immunological and molecular tools. Cell & Bioscience, v. 5, p. 31, 2015.2045-3701https://www.arca.fiocruz.br/handle/icict/2317010.1186/s13578-015-0021-2porLeishmaniose CutâneaLeishmaniose VisceralTécnicas de Diagnóstico MolecularCutaneous leishmaniasisDiagnosisImmunological toolsMolecular toolsVisceral leishmaniasisLeishmaniose CutâneaDiagnósticoLeishmaniose VisceralTécnicas de Diagnóstico MolecularLeishmaniases diagnosis: an update on the use of immunological and molecular toolsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, BrasilLeishmaniases are caused by obligate intracellular protozoan parasites of the genus Leishmania. They cause a spectrum of diseases, most notably visceral (VL), cutaneous (CL), and mucosal (ML) leishmaniasis, which affect millions of people around the world, each year. Despite scientific advances, leishmaniases cases are expanding, constituting an important public health problem. Immunological and molecular diagnostic tools have been increasingly applied for the early detection of these parasitic infections, since the existence of limitations in clinical and parasitological examinations may provide false results, thus interfering in epidemiological research and diseases control. Although there is a great diversity of available immunological assays, important common deficiencies persist, which explains the current exploration of the molecular biology in research fields, especially the Polymerase Chain Reaction (PCR) and its variants, such as real-time quantitative PCR. However, in the last years, significant results have also been reached inside of immunological context (especially by Flow Cytometry), for humans and dogs, demonstrated by research works of the New and Old worlds. In spite of their potential to clarify and minimize the present global situation of the diseases, the implementation of molecular or immunological innovative reference assays for VL and CL at health services is still a challenge due to several reasons, including lack of standardization among laboratories and structural concerns. In this article we bring classical and current information about technological advances for the immunological and molecular leishmaniases diagnosis, their features, and applications.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23170/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL26097678 2015 cav-lei.oa.pdf26097678 2015 cav-lei.oa.pdfapplication/pdf620283https://www.arca.fiocruz.br/bitstream/icict/23170/2/26097678%202015%20cav-lei.oa.pdfe3fd632b76debad19dcde66fbaaa0ec3MD52TEXT26097678 2015 cav-lei.oa.pdf.txt26097678 2015 cav-lei.oa.pdf.txtExtracted texttext/plain59880https://www.arca.fiocruz.br/bitstream/icict/23170/3/26097678%202015%20cav-lei.oa.pdf.txt06f4a6fec372bb9769b8e120bf07c4f3MD53icict/231702018-08-15 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| dc.title.pt_BR.fl_str_mv |
Leishmaniases diagnosis: an update on the use of immunological and molecular tools |
| title |
Leishmaniases diagnosis: an update on the use of immunological and molecular tools |
| spellingShingle |
Leishmaniases diagnosis: an update on the use of immunological and molecular tools Paiva-Cavalcanti, Milena de Leishmaniose Cutânea Leishmaniose Visceral Técnicas de Diagnóstico Molecular Cutaneous leishmaniasis Diagnosis Immunological tools Molecular tools Visceral leishmaniasis Leishmaniose Cutânea Diagnóstico Leishmaniose Visceral Técnicas de Diagnóstico Molecular |
| title_short |
Leishmaniases diagnosis: an update on the use of immunological and molecular tools |
| title_full |
Leishmaniases diagnosis: an update on the use of immunological and molecular tools |
| title_fullStr |
Leishmaniases diagnosis: an update on the use of immunological and molecular tools |
| title_full_unstemmed |
Leishmaniases diagnosis: an update on the use of immunological and molecular tools |
| title_sort |
Leishmaniases diagnosis: an update on the use of immunological and molecular tools |
| author |
Paiva-Cavalcanti, Milena de |
| author_facet |
Paiva-Cavalcanti, Milena de Morais, Rayana Carla Silva de Pessoa-E-Silva, Rômulo Trajano-Silva, Lays Adrianne Mendonça Gonçalves-de-Albuquerque, Suênia da Cunha Tavares, Diego de Hollanda Cavalcanti Brelaz-de-Castro, Maria Carolina Accioly Silva, Rafael de Freitas E. Pereira, Valéria Rêgo Alves |
| author_role |
author |
| author2 |
Morais, Rayana Carla Silva de Pessoa-E-Silva, Rômulo Trajano-Silva, Lays Adrianne Mendonça Gonçalves-de-Albuquerque, Suênia da Cunha Tavares, Diego de Hollanda Cavalcanti Brelaz-de-Castro, Maria Carolina Accioly Silva, Rafael de Freitas E. Pereira, Valéria Rêgo Alves |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Paiva-Cavalcanti, Milena de Morais, Rayana Carla Silva de Pessoa-E-Silva, Rômulo Trajano-Silva, Lays Adrianne Mendonça Gonçalves-de-Albuquerque, Suênia da Cunha Tavares, Diego de Hollanda Cavalcanti Brelaz-de-Castro, Maria Carolina Accioly Silva, Rafael de Freitas E. Pereira, Valéria Rêgo Alves |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose Cutânea Leishmaniose Visceral Técnicas de Diagnóstico Molecular |
| topic |
Leishmaniose Cutânea Leishmaniose Visceral Técnicas de Diagnóstico Molecular Cutaneous leishmaniasis Diagnosis Immunological tools Molecular tools Visceral leishmaniasis Leishmaniose Cutânea Diagnóstico Leishmaniose Visceral Técnicas de Diagnóstico Molecular |
| dc.subject.en.pt_BR.fl_str_mv |
Cutaneous leishmaniasis Diagnosis Immunological tools Molecular tools Visceral leishmaniasis |
| dc.subject.decs.pt_BR.fl_str_mv |
Leishmaniose Cutânea Diagnóstico Leishmaniose Visceral Técnicas de Diagnóstico Molecular |
| description |
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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2015 |
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2015 |
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2017-11-14T13:55:45Z |
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2017-11-14T13:55:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
DE PAIVA-CAVALCANTI, M. et al. Leishmaniases diagnosis: an update on the use of immunological and molecular tools. Cell & Bioscience, v. 5, p. 31, 2015. |
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https://www.arca.fiocruz.br/handle/icict/23170 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2045-3701 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s13578-015-0021-2 |
| identifier_str_mv |
DE PAIVA-CAVALCANTI, M. et al. Leishmaniases diagnosis: an update on the use of immunological and molecular tools. Cell & Bioscience, v. 5, p. 31, 2015. 2045-3701 10.1186/s13578-015-0021-2 |
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