Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1590/s0074-02762007005000007 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40269 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. |
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Barreto, Débora FerreiraTakiya, Christina MaedaSchatzmayr, Hermann GonçalvesNogueira, Rita Maria RibeiroFarias Filho, José da CostaBarth, Ortrud Monika2020-03-10T12:35:33Z2020-03-10T12:35:33Z2007BARRETO, Débora Ferreira et al. Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 2, p. 175-182, Mar. 2007.0074-0206https://www.arca.fiocruz.br/handle/icict/4026910.1590/s0074-027620070050000071678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzVírus da Dengue tipo 2MacrófagosMastócitosCamundongos BALB / cUltraestruturaDengue-2 virusBALB/c miceC6/36 cell lineMacrophageMast cellUltrastructureHistopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Histological and ultrastructural alterations in lung tissue of BALB/c mice infected with dengue virus serotype 2 (non-neuroadapted), by intraperitoneal and intravenous routes were analyzed. Lung tissues were processed following the standard techniques for photonic and electron transmission microscopies. Histopathological and ultrastructural studies showed interstitial pneumonia, characterized by the presence of mononuclear cells. In the mouse model, the dengue virus serotype 2 seems to led to a transient inflammatory process without extensive damage to the interalveolar septa, but caused focal alterations of the blood-exchange barrier. Endothelial cells of blood capillaries exhibited phyllopodia suggesting activation by presence of dengue virus. Morphometrical analysis of mast cells showed an expressive increase of the number of these cells in peribronchiolar spaces and adjacent areas to the interalveolar septa. Alveolar macrophages showed particles dengue virus-like inside rough endoplasmic reticulum and Golgi complex, suggesting viral replication. The tissue alterations observed in our experimental model were similar to the observed in human cases of dengue fever and dengue hemorrhagic fever. Our results show that BALB/c mice are permissive host for dengue virus serotype 2 replication and therefore provides an useful model to study of morphological aspects of dengue virus infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40269/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOrtrudBarth_DebraBarreto_etal_IOC_2007.pdfOrtrudBarth_DebraBarreto_etal_IOC_2007.pdfapplication/pdf6204757https://www.arca.fiocruz.br/bitstream/icict/40269/2/OrtrudBarth_DebraBarreto_etal_IOC_2007.pdf46827ce79812b88ea66bc558554d3d3aMD52TEXTOrtrudBarth_DebraBarreto_etal_IOC_2007.pdf.txtOrtrudBarth_DebraBarreto_etal_IOC_2007.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2 |
| title |
Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2 |
| spellingShingle |
Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2 Barreto, Débora Ferreira Vírus da Dengue tipo 2 Macrófagos Mastócitos Camundongos BALB / c Ultraestrutura Dengue-2 virus BALB/c mice C6/36 cell line Macrophage Mast cell Ultrastructure |
| title_short |
Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2 |
| title_full |
Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2 |
| title_fullStr |
Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2 |
| title_full_unstemmed |
Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2 |
| title_sort |
Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2 |
| author |
Barreto, Débora Ferreira |
| author_facet |
Barreto, Débora Ferreira Takiya, Christina Maeda Schatzmayr, Hermann Gonçalves Nogueira, Rita Maria Ribeiro Farias Filho, José da Costa Barth, Ortrud Monika |
| author_role |
author |
| author2 |
Takiya, Christina Maeda Schatzmayr, Hermann Gonçalves Nogueira, Rita Maria Ribeiro Farias Filho, José da Costa Barth, Ortrud Monika |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Barreto, Débora Ferreira Takiya, Christina Maeda Schatzmayr, Hermann Gonçalves Nogueira, Rita Maria Ribeiro Farias Filho, José da Costa Barth, Ortrud Monika |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus da Dengue tipo 2 Macrófagos Mastócitos Camundongos BALB / c Ultraestrutura |
| topic |
Vírus da Dengue tipo 2 Macrófagos Mastócitos Camundongos BALB / c Ultraestrutura Dengue-2 virus BALB/c mice C6/36 cell line Macrophage Mast cell Ultrastructure |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue-2 virus BALB/c mice C6/36 cell line Macrophage Mast cell Ultrastructure |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. |
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2007 |
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2007 |
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2020-03-10T12:35:33Z |
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2020-03-10T12:35:33Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BARRETO, Débora Ferreira et al. Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 2, p. 175-182, Mar. 2007. |
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https://www.arca.fiocruz.br/handle/icict/40269 |
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0074-0206 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/s0074-02762007005000007 |
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1678-8060 |
| identifier_str_mv |
BARRETO, Débora Ferreira et al. Histopathological and ultrastructural aspects of mice lungs experimentally infected with dengue virus serotype 2. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 2, p. 175-182, Mar. 2007. 0074-0206 10.1590/s0074-02762007005000007 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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