Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26115 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil. |
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Vieira, Debora Ferreira BarretoSchatzmayr, Hermann GonçalvesTakiya, Christina MaedaJácome, Fernanda CunhaSilva, Manoel Enderson VieiraFaria, Nieli Rodrigues da CostaNogueira, Rita Maria RibeiroBarth, Ortrud Monika2018-04-26T10:59:30Z2018-04-26T10:59:30Z2010VIEIRA, Debora Ferreira Barreto; et al. Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2. Virus Review and Research, v.15, n.2, 27p, 2010.1519-2563https://www.arca.fiocruz.br/handle/icict/261152357-9323engSociedade Brasileira de VirologiaDengue Virus-Tipo 2Dengue Virus Tipo1FígadoUltraestruturaHistopatololgiaCamundongos Endogâmicos BALB Cdengue-2 virusdengue-1 virusBALB/c miceliverultrastructurehistopathologyMorphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biológicas. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil.Histopathological and ultrastructural aspects of liver of non-neuroadapted BALB/c mice reinfected by the intravenous route with dengue virus serotypes 1 and 2 were presented. The hepatic tissue was processed following the standard techniques for photonic and transmission electron microscopy. Morphological studies showed vacuolization of hepatocytes, inflammatory cells inside sinusoidal capillaries, enlargement of sinusoidal capillaries, foci of hemorrhage inside the interstitium, increase of surface density of reticular fibres, increase of numerical density of sinusoidal cells, decrease of surface density of hepatocytes, edema in the peri centrolobular vein space and presence of phyllopods and pseudopod-like extensions in endothelial cells. DENV particles, virus antigens and DENV RNA were observed in mosquito cells (C6/36) inoculated with sera of the animals 72 hours post-reinfection. The hepatic alterations observed in our experimental model were similar to those observed in human cases of dengue hemorrhagic fever. The present study shows that BALB/c mice reinfected with a heterologous serotype of DENV develop more severe lesions than those observed in mice in primary infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26115/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALdebora_vieira_etal_IOC_2011.pdfdebora_vieira_etal_IOC_2011.pdfapplication/pdf1565061https://www.arca.fiocruz.br/bitstream/icict/26115/2/debora_vieira_etal_IOC_2011.pdf0712963f06509eec67a0a67bacaa8696MD52TEXTdebora_vieira_etal_IOC_2011.pdf.txtdebora_vieira_etal_IOC_2011.pdf.txtExtracted texttext/plain45723https://www.arca.fiocruz.br/bitstream/icict/26115/3/debora_vieira_etal_IOC_2011.pdf.txt2ed28e894123905a3a5da9c10f7e32cdMD53icict/261152018-08-15 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| dc.title.pt_BR.fl_str_mv |
Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2 |
| title |
Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2 |
| spellingShingle |
Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2 Vieira, Debora Ferreira Barreto Dengue Virus-Tipo 2 Dengue Virus Tipo1 Fígado Ultraestrutura Histopatololgia Camundongos Endogâmicos BALB C dengue-2 virus dengue-1 virus BALB/c mice liver ultrastructure histopathology |
| title_short |
Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2 |
| title_full |
Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2 |
| title_fullStr |
Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2 |
| title_full_unstemmed |
Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2 |
| title_sort |
Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2 |
| author |
Vieira, Debora Ferreira Barreto |
| author_facet |
Vieira, Debora Ferreira Barreto Schatzmayr, Hermann Gonçalves Takiya, Christina Maeda Jácome, Fernanda Cunha Silva, Manoel Enderson Vieira Faria, Nieli Rodrigues da Costa Nogueira, Rita Maria Ribeiro Barth, Ortrud Monika |
| author_role |
author |
| author2 |
Schatzmayr, Hermann Gonçalves Takiya, Christina Maeda Jácome, Fernanda Cunha Silva, Manoel Enderson Vieira Faria, Nieli Rodrigues da Costa Nogueira, Rita Maria Ribeiro Barth, Ortrud Monika |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vieira, Debora Ferreira Barreto Schatzmayr, Hermann Gonçalves Takiya, Christina Maeda Jácome, Fernanda Cunha Silva, Manoel Enderson Vieira Faria, Nieli Rodrigues da Costa Nogueira, Rita Maria Ribeiro Barth, Ortrud Monika |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Virus-Tipo 2 Dengue Virus Tipo1 Fígado Ultraestrutura Histopatololgia Camundongos Endogâmicos BALB C |
| topic |
Dengue Virus-Tipo 2 Dengue Virus Tipo1 Fígado Ultraestrutura Histopatololgia Camundongos Endogâmicos BALB C dengue-2 virus dengue-1 virus BALB/c mice liver ultrastructure histopathology |
| dc.subject.en.pt_BR.fl_str_mv |
dengue-2 virus dengue-1 virus BALB/c mice liver ultrastructure histopathology |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil. |
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2010 |
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2010 |
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2018-04-26T10:59:30Z |
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2018-04-26T10:59:30Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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VIEIRA, Debora Ferreira Barreto; et al. Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2. Virus Review and Research, v.15, n.2, 27p, 2010. |
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https://www.arca.fiocruz.br/handle/icict/26115 |
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1519-2563 |
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2357-9323 |
| identifier_str_mv |
VIEIRA, Debora Ferreira Barreto; et al. Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2. Virus Review and Research, v.15, n.2, 27p, 2010. 1519-2563 2357-9323 |
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Sociedade Brasileira de Virologia |
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Sociedade Brasileira de Virologia |
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