Alternative complement pathway deregulation is correlated with dengue severity

Detalhes bibliográficos
Autor(a) principal: Nascimento, Eduardo J. M.
Data de Publicação: 2009
Outros Autores: Silva, Ana M., Cordeiro, Marli T., Brito, Carlos A., Gil, Laura H. V. G., Braga-Neto, Ulisses, Marques, Ernesto T. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/journal.pone.0006782
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27827
Resumo: Instituto Nacional de Alergia e Doenças Infecciosas (NIAID / NIH) através do Grant U19 AI56541 e do PDTIS RVR09-FIOCRUZ.
id CRUZ_51b37128ffe153df2db5f76b499bb00a
oai_identifier_str oai:www.arca.fiocruz.br:icict/27827
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Nascimento, Eduardo J. M.Silva, Ana M.Cordeiro, Marli T.Brito, Carlos A.Gil, Laura H. V. G.Braga-Neto, UlissesMarques, Ernesto T. A.2018-08-03T11:55:04Z2018-08-03T11:55:04Z2009NASCIMENTO, Eduardo J. M. et al. Alternative Complement Pathway Deregulation Is Correlated with Dengue Severity. PloS One, v. 4, n. 8, p. e6782, 26 ago. 2009.1932-6203https://www.arca.fiocruz.br/handle/icict/2782710.1371/journal.pone.0006782Instituto Nacional de Alergia e Doenças Infecciosas (NIAID / NIH) através do Grant U19 AI56541 e do PDTIS RVR09-FIOCRUZ.The Johns Hopkins School of Medicine. Division of Infectious Diseases. Department of Medicine. Baltimore, Maryland, United States of America.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.Texas A&M University. Department of Electrical and Computer Engineering. College Station, Texas, United States of America.The Johns Hopkins School of Medicine. Division of Infectious Diseases. Department of Medicine. Baltimore, Maryland, United States of America / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / The Johns Hopkins School of Medicine. Department of Pharmacology and Molecular Sciences. Baltimore, Maryland, United States of America.The complement system, a key component that links the innate and adaptive immune responses, has three pathways: the classical, lectin, and alternative pathways. In the present study, we have analyzed the levels of various complement components in blood samples from dengue fever (DF) and dengue hemorrhagic fever (DHF) patients and found that the level of complement activation is associated with disease severity.engAlternative complement pathway deregulation is correlated with dengue severityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAdolescenteAdultoAtivação ComplementarProteínas do Sistema Complementar / metabolismoDengue / metabolismoDengue / fisiopatologiaEnsaio de Imunoadsorção EnzimáticaFêmeaHumanosMasculinoMeia idadeÍndice de gravidade da doençaAdulto joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAlternative Complement Pathway Deregulation Is.PDFAlternative Complement Pathway Deregulation Is.PDFapplication/pdf429199https://www.arca.fiocruz.br/bitstream/icict/27827/2/Alternative%20Complement%20Pathway%20Deregulation%20Is.PDF2b86d3f8dd8b299228d6a14d8f8808f2MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27827/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTAlternative Complement Pathway Deregulation Is.PDF.txtAlternative Complement Pathway Deregulation Is.PDF.txtExtracted texttext/plain56913https://www.arca.fiocruz.br/bitstream/icict/27827/4/Alternative%20Complement%20Pathway%20Deregulation%20Is.PDF.txtd1f7f5ffa3e93161e16fd729a3811cd9MD54icict/278272018-08-15 03:26:29.136oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-08-15T06:26:29Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Alternative complement pathway deregulation is correlated with dengue severity
title Alternative complement pathway deregulation is correlated with dengue severity
spellingShingle Alternative complement pathway deregulation is correlated with dengue severity
Nascimento, Eduardo J. M.
Adolescente
Adulto
Ativação Complementar
Proteínas do Sistema Complementar / metabolismo
Dengue / metabolismo
Dengue / fisiopatologia
Ensaio de Imunoadsorção Enzimática
Fêmea
Humanos
Masculino
Meia idade
Índice de gravidade da doença
Adulto jovem
title_short Alternative complement pathway deregulation is correlated with dengue severity
title_full Alternative complement pathway deregulation is correlated with dengue severity
title_fullStr Alternative complement pathway deregulation is correlated with dengue severity
title_full_unstemmed Alternative complement pathway deregulation is correlated with dengue severity
title_sort Alternative complement pathway deregulation is correlated with dengue severity
author Nascimento, Eduardo J. M.
author_facet Nascimento, Eduardo J. M.
Silva, Ana M.
Cordeiro, Marli T.
Brito, Carlos A.
Gil, Laura H. V. G.
Braga-Neto, Ulisses
Marques, Ernesto T. A.
author_role author
author2 Silva, Ana M.
Cordeiro, Marli T.
Brito, Carlos A.
Gil, Laura H. V. G.
Braga-Neto, Ulisses
Marques, Ernesto T. A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nascimento, Eduardo J. M.
Silva, Ana M.
Cordeiro, Marli T.
Brito, Carlos A.
Gil, Laura H. V. G.
Braga-Neto, Ulisses
Marques, Ernesto T. A.
dc.subject.decs.pt_BR.fl_str_mv Adolescente
Adulto
Ativação Complementar
Proteínas do Sistema Complementar / metabolismo
Dengue / metabolismo
Dengue / fisiopatologia
Ensaio de Imunoadsorção Enzimática
Fêmea
Humanos
Masculino
Meia idade
Índice de gravidade da doença
Adulto jovem
topic Adolescente
Adulto
Ativação Complementar
Proteínas do Sistema Complementar / metabolismo
Dengue / metabolismo
Dengue / fisiopatologia
Ensaio de Imunoadsorção Enzimática
Fêmea
Humanos
Masculino
Meia idade
Índice de gravidade da doença
Adulto jovem
description Instituto Nacional de Alergia e Doenças Infecciosas (NIAID / NIH) através do Grant U19 AI56541 e do PDTIS RVR09-FIOCRUZ.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2018-08-03T11:55:04Z
dc.date.available.fl_str_mv 2018-08-03T11:55:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NASCIMENTO, Eduardo J. M. et al. Alternative Complement Pathway Deregulation Is Correlated with Dengue Severity. PloS One, v. 4, n. 8, p. e6782, 26 ago. 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27827
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0006782
identifier_str_mv NASCIMENTO, Eduardo J. M. et al. Alternative Complement Pathway Deregulation Is Correlated with Dengue Severity. PloS One, v. 4, n. 8, p. e6782, 26 ago. 2009.
1932-6203
10.1371/journal.pone.0006782
url https://www.arca.fiocruz.br/handle/icict/27827
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/27827/2/Alternative%20Complement%20Pathway%20Deregulation%20Is.PDF
https://www.arca.fiocruz.br/bitstream/icict/27827/3/license.txt
https://www.arca.fiocruz.br/bitstream/icict/27827/4/Alternative%20Complement%20Pathway%20Deregulation%20Is.PDF.txt
bitstream.checksum.fl_str_mv 2b86d3f8dd8b299228d6a14d8f8808f2
5a560609d32a3863062d77ff32785d58
d1f7f5ffa3e93161e16fd729a3811cd9
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1822791895976247296

Registros relacionados