Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.

Pereira, Valéria Rêgo Alves; Lorena, Virginia Maria Barros de; Nakazawa, Mineo; Luna, Carlos Feitosa; Silva, Edimilson Domingos da; Ferreira, Antonio Gomes Pinto; Krieger, Marco Aurélio; Goldenberg, Samuel; Soares, Milena Botelho Pereira; Coutinho, Eridan de Medeiros; Oliveira, Rodrigo Corrêa; Gomes, Yara de Miranda

Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.

Detalhes bibliográficos
Autor(a) principal:	Pereira, Valéria Rêgo Alves
Data de Publicação:	2005
Outros Autores:	Lorena, Virginia Maria Barros de, Nakazawa, Mineo, Luna, Carlos Feitosa, Silva, Edimilson Domingos da, Ferreira, Antonio Gomes Pinto, Krieger, Marco Aurélio, Goldenberg, Samuel, Soares, Milena Botelho Pereira, Coutinho, Eridan de Medeiros, Oliveira, Rodrigo Corrêa, Gomes, Yara de Miranda
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/9993
Resumo:	Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil

Metadados do item

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spelling	Pereira, Valéria Rêgo AlvesLorena, Virginia Maria Barros deNakazawa, MineoLuna, Carlos FeitosaSilva, Edimilson Domingos daFerreira, Antonio Gomes PintoKrieger, Marco AurélioGoldenberg, SamuelSoares, Milena Botelho PereiraCoutinho, Eridan de MedeirosOliveira, Rodrigo CorrêaGomes, Yara de Miranda2015-04-14T17:25:18Z2015-04-14T17:25:18Z2005PEREIRA, V. R. A. et al. Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection. Parasitology Research, v. 96, n. 3, p. 154-161, 2005.0932-0113https://www.arca.fiocruz.br/handle/icict/999310.1007/s00436-005-1336-4engSpringer VerlagHumoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilFundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilIn previous studies, cytoplasmic repetitive antigen (CRA) and flagellar repetitive antigen (FRA) proteins induced specific humoral and cellular immune responses in susceptible and resistant mice in the absence of Trypanosoma cruzi infection with a significant induction of the Interferon-gamma (IFN-gamma) production in those animals. In this follow-up paper, the immunostimulatory and protective effects of these proteins were evaluated by immunizing with CRA or FRA antigens, BALB/c and C57BL/6 mice and challenging with a T. cruzi (Y strain). Both proteins induced humoral response with high levels of IgG isotypes as well as cellular immunity with high levels of IFN-gamma when compared to controls. However, the lymphocyte proliferative response was minimal. The survival rate at 30 days post-infection was significant in CRA (60%) or FRA (50%)--immunized BALB/c mice and CRA (83.3%)--immunized C57BL/6 mice. Taken as a whole these findings indicate that CRA and FRA are immunogenic and potentially important for protective immunity.Anticorpos Antiprotozoários/sangueAntígenos de Protozoários/imunologiaDoença de Chagas/imunologiaProteínas Recombinantes/imunologiaTrypanosoma cruzi/imunologiaAnimaisAntígenos de Protozoários/administração & dosagemModelos Animais de DoençasEnsaio de Imunoadsorção EnzimáticaImunidade CelularImunoglobulina G/sangueInterferon gama/análiseLinfócitos/imunologiaMasculinoCamundongosCamundongos Endogâmicos BALB Cinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9993/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALPereira VRA Humoral and cellular immune.........pdfPereira VRA Humoral and cellular immune.........pdfapplication/pdf283731https://www.arca.fiocruz.br/bitstream/icict/9993/2/Pereira%20VRA%20Humoral%20and%20cellular%20immune.........pdfd693fb5d4ffab78266f737a194ac7a59MD52TEXTPereira VRA Humoral and cellular immune.........pdf.txtPereira VRA Humoral and cellular immune.........pdf.txtExtracted texttext/plain34518https://www.arca.fiocruz.br/bitstream/icict/9993/3/Pereira%20VRA%20Humoral%20and%20cellular%20immune.........pdf.txt11cd0a474b2aea38cb6690f8a284f947MD53icict/99932023-03-15 14:33:10.228oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.
title	Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.
spellingShingle	Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection. Pereira, Valéria Rêgo Alves Anticorpos Antiprotozoários/sangue Antígenos de Protozoários/imunologia Doença de Chagas/imunologia Proteínas Recombinantes/imunologia Trypanosoma cruzi/imunologia Animais Antígenos de Protozoários/administração & dosagem Modelos Animais de Doenças Ensaio de Imunoadsorção Enzimática Imunidade Celular Imunoglobulina G/sangue Interferon gama/análise Linfócitos/imunologia Masculino Camundongos Camundongos Endogâmicos BALB C
title_short	Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.
title_full	Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.
title_fullStr	Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.
title_full_unstemmed	Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.
title_sort	Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.
author	Pereira, Valéria Rêgo Alves
author_facet	Pereira, Valéria Rêgo Alves Lorena, Virginia Maria Barros de Nakazawa, Mineo Luna, Carlos Feitosa Silva, Edimilson Domingos da Ferreira, Antonio Gomes Pinto Krieger, Marco Aurélio Goldenberg, Samuel Soares, Milena Botelho Pereira Coutinho, Eridan de Medeiros Oliveira, Rodrigo Corrêa Gomes, Yara de Miranda
author_role	author
author2	Lorena, Virginia Maria Barros de Nakazawa, Mineo Luna, Carlos Feitosa Silva, Edimilson Domingos da Ferreira, Antonio Gomes Pinto Krieger, Marco Aurélio Goldenberg, Samuel Soares, Milena Botelho Pereira Coutinho, Eridan de Medeiros Oliveira, Rodrigo Corrêa Gomes, Yara de Miranda
author2_role	author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Pereira, Valéria Rêgo Alves Lorena, Virginia Maria Barros de Nakazawa, Mineo Luna, Carlos Feitosa Silva, Edimilson Domingos da Ferreira, Antonio Gomes Pinto Krieger, Marco Aurélio Goldenberg, Samuel Soares, Milena Botelho Pereira Coutinho, Eridan de Medeiros Oliveira, Rodrigo Corrêa Gomes, Yara de Miranda
dc.subject.decs.pt_BR.fl_str_mv	Anticorpos Antiprotozoários/sangue Antígenos de Protozoários/imunologia Doença de Chagas/imunologia Proteínas Recombinantes/imunologia Trypanosoma cruzi/imunologia Animais Antígenos de Protozoários/administração & dosagem Modelos Animais de Doenças Ensaio de Imunoadsorção Enzimática Imunidade Celular Imunoglobulina G/sangue Interferon gama/análise Linfócitos/imunologia Masculino Camundongos Camundongos Endogâmicos BALB C
topic	Anticorpos Antiprotozoários/sangue Antígenos de Protozoários/imunologia Doença de Chagas/imunologia Proteínas Recombinantes/imunologia Trypanosoma cruzi/imunologia Animais Antígenos de Protozoários/administração & dosagem Modelos Animais de Doenças Ensaio de Imunoadsorção Enzimática Imunidade Celular Imunoglobulina G/sangue Interferon gama/análise Linfócitos/imunologia Masculino Camundongos Camundongos Endogâmicos BALB C
description	Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil
publishDate	2005
dc.date.issued.fl_str_mv	2005
dc.date.accessioned.fl_str_mv	2015-04-14T17:25:18Z
dc.date.available.fl_str_mv	2015-04-14T17:25:18Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	PEREIRA, V. R. A. et al. Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection. Parasitology Research, v. 96, n. 3, p. 154-161, 2005.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/9993
dc.identifier.issn.none.fl_str_mv	0932-0113
dc.identifier.doi.none.fl_str_mv	10.1007/s00436-005-1336-4
identifier_str_mv	PEREIRA, V. R. A. et al. Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection. Parasitology Research, v. 96, n. 3, p. 154-161, 2005. 0932-0113 10.1007/s00436-005-1336-4
url	https://www.arca.fiocruz.br/handle/icict/9993
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Springer Verlag
publisher.none.fl_str_mv	Springer Verlag
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.

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