Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions

Detalhes bibliográficos
Autor(a) principal: Antonio, Liliane de Fátima
Data de Publicação: 2017
Outros Autores: Lyra, Marcelo Rosandiski, Saheki, Maurício Naoto, Schubach, Armando de Oliveira, Miranda, Luciana de Freitas Campos, Madeira, Maria de Fátima, Lourenço, Maria Cristina da Silva, Fagundes, Aline, Ribeiro, Érica Aparecida dos Santos, Barreto, Leonardo, Pimentel, Maria Inês Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31204
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.
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spelling Antonio, Liliane de FátimaLyra, Marcelo RosandiskiSaheki, Maurício NaotoSchubach, Armando de OliveiraMiranda, Luciana de Freitas CamposMadeira, Maria de FátimaLourenço, Maria Cristina da SilvaFagundes, AlineRibeiro, Érica Aparecida dos SantosBarreto, LeonardoPimentel, Maria Inês Fernandes2019-01-22T10:51:45Z2019-01-22T10:51:45Z2017ANTONIO, Liliane de Fátima et al. Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 9, p. 640-646, Sep. 2017.0074-0276https://www.arca.fiocruz.br/handle/icict/3120410.1590/0074-027601605571678-8060engInstituto Oswaldo CruzEffect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Bacteriologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Bacteriologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Bacteriologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.BACKGROUND Cutaneous leishmaniasis (CL) generally presents with a single or several localised cutaneous ulcers without involvement of mucous membranes. Ulcerated lesions are susceptible to secondary contamination that may slow the healing process. OBJECTIVE This study verified the influence of non-parasitic wound infection on wound closure (epithelialisation) and total healing. METHODS Twenty-five patients with a confirmed diagnosis of CL and ulcerated lesions underwent biopsy of ulcer borders. One direct microbial parameter (germ identification in cultures) and four indirect clinical parameters (secretion, pain, burning sensation, pruritus) were analysed. FINDINGS Biopsies of ten lesions showed secondary infection by one or two microorganisms (Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, Streptococcus pyogenes and Candida parapsilosis). “Secretion” and “burning sensation” influenced epithelialisation time but not total healing time. Positive detection of germs in the ulcer border and “pain” and “pruritus” revealed no influence on wound closure. CONCLUSIONS Our borderline proof of clinical CL ulcer infection inhibiting CL wound healing supports the need to follow antimicrobial stewardship in CL ulcer management, which was recently proposed for all chronic wounds.Cutaneous leishmaniasisWound infectionOpportunistic infectioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31204/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Antonio_Liliane_etal_INI_2017.pdfve_Antonio_Liliane_etal_INI_2017.pdfapplication/pdf281618https://www.arca.fiocruz.br/bitstream/icict/31204/2/ve_Antonio_Liliane_etal_INI_2017.pdf7b347534080ab44f5472c17e51b9494fMD52TEXTve_Antonio_Liliane_etal_INI_2017.pdf.txtve_Antonio_Liliane_etal_INI_2017.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions
title Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions
spellingShingle Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions
Antonio, Liliane de Fátima
Cutaneous leishmaniasis
Wound infection
Opportunistic infection
title_short Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions
title_full Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions
title_fullStr Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions
title_full_unstemmed Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions
title_sort Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions
author Antonio, Liliane de Fátima
author_facet Antonio, Liliane de Fátima
Lyra, Marcelo Rosandiski
Saheki, Maurício Naoto
Schubach, Armando de Oliveira
Miranda, Luciana de Freitas Campos
Madeira, Maria de Fátima
Lourenço, Maria Cristina da Silva
Fagundes, Aline
Ribeiro, Érica Aparecida dos Santos
Barreto, Leonardo
Pimentel, Maria Inês Fernandes
author_role author
author2 Lyra, Marcelo Rosandiski
Saheki, Maurício Naoto
Schubach, Armando de Oliveira
Miranda, Luciana de Freitas Campos
Madeira, Maria de Fátima
Lourenço, Maria Cristina da Silva
Fagundes, Aline
Ribeiro, Érica Aparecida dos Santos
Barreto, Leonardo
Pimentel, Maria Inês Fernandes
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Antonio, Liliane de Fátima
Lyra, Marcelo Rosandiski
Saheki, Maurício Naoto
Schubach, Armando de Oliveira
Miranda, Luciana de Freitas Campos
Madeira, Maria de Fátima
Lourenço, Maria Cristina da Silva
Fagundes, Aline
Ribeiro, Érica Aparecida dos Santos
Barreto, Leonardo
Pimentel, Maria Inês Fernandes
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
Wound infection
Opportunistic infection
topic Cutaneous leishmaniasis
Wound infection
Opportunistic infection
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-01-22T10:51:45Z
dc.date.available.fl_str_mv 2019-01-22T10:51:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ANTONIO, Liliane de Fátima et al. Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 9, p. 640-646, Sep. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31204
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760160557
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv ANTONIO, Liliane de Fátima et al. Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 9, p. 640-646, Sep. 2017.
0074-0276
10.1590/0074-02760160557
1678-8060
url https://www.arca.fiocruz.br/handle/icict/31204
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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