Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.

Santos, Luara Isabela dos; Galvão Filho, Bruno; Faria, Paula Cristina de; Junqueira, Caroline; Dutra, Miriam Santos; Teixeira, Santuza Maria Ribeiro; Rodrigues, Maurício Martins; Ritter, Gerd; Bannard, Oliver; Fearon, Douglas Thomas; Antonelli, Lis Ribeiro do Valle; Gazzinelli, Ricardo Tostes

Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.

Detalhes bibliográficos
Autor(a) principal:	Santos, Luara Isabela dos
Data de Publicação:	2015
Outros Autores:	Galvão Filho, Bruno, Faria, Paula Cristina de, Junqueira, Caroline, Dutra, Miriam Santos, Teixeira, Santuza Maria Ribeiro, Rodrigues, Maurício Martins, Ritter, Gerd, Bannard, Oliver, Fearon, Douglas Thomas, Antonelli, Lis Ribeiro do Valle, Gazzinelli, Ricardo Tostes
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/15739
Resumo:	2017-01-01

Metadados do item

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network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Santos, Luara Isabela dosGalvão Filho, BrunoFaria, Paula Cristina deJunqueira, CarolineDutra, Miriam SantosTeixeira, Santuza Maria RibeiroRodrigues, Maurício MartinsRitter, GerdBannard, OliverFearon, Douglas ThomasAntonelli, Lis Ribeiro do ValleGazzinelli, Ricardo Tostes2016-09-08T19:15:28Z2016-09-08T19:15:28Z2015SANTOS, Luara Isabela dos et al. Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1. Cancer Immunol Immunother., vol. 64, n. 3, p. 311-323, 2015.0340-7004https://www.arca.fiocruz.br/handle/icict/1573910.1007/s00262-014-1634-8engSpringer-VerlagbBlockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2017-01-01Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, BrasilUniversidade Federal de São Paulo. Escola Paulista de Medicina. Centro de Terapia Celular e Molecular. São Paulo, SP, BrasilLudwig Institute for Cancer Research. New York Branch at Memorial Sloan-Kettering Cancer Center. New York, NY, USAFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, BrasilThe development of cancer immunotherapy has long been a challenge. Here, we report that prophylactic vaccination with a highly attenuated Trypanosoma cruzi strain expressing NY-ESO-1 (CL-14-NY-ESO-1) induces both effector memory and effector CD8(+) T lymphocytes that efficiently prevent tumor development. However, the therapeutic effect of such a vaccine is limited. We also demonstrate that blockade of Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) during vaccination enhances the frequency of NY-ESO-1-specific effector CD8(+) T cells producing IFN-γ and promotes lymphocyte migration to the tumor infiltrate. As a result, therapy with CL-14-NY-ESO-1 together with anti-CTLA-4 is highly effective in controlling the development of an established melanoma.Antigens, Neoplasm/geneticsImmunotherapy/methodsMelanoma, Experimental/parasitologyRecombinant Proteins/geneticsCTAG1B protein, humaninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15739/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Luara_Santos_etal_ Blockade_CPqRR_2015.pdfve_Luara_Santos_etal_ Blockade_CPqRR_2015.pdfapplication/pdf6445463https://www.arca.fiocruz.br/bitstream/icict/15739/2/ve_Luara_Santos_etal_%20Blockade_CPqRR_2015.pdffd4b101a2cd6d360db38362fecfa49cfMD52TEXTve_Luara_Santos_etal_ Blockade_CPqRR_2015.pdf.txtve_Luara_Santos_etal_ Blockade_CPqRR_2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.
title	Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.
spellingShingle	Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1. Santos, Luara Isabela dos Antigens, Neoplasm/genetics Immunotherapy/methods Melanoma, Experimental/parasitology Recombinant Proteins/genetics CTAG1B protein, human
title_short	Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.
title_full	Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.
title_fullStr	Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.
title_full_unstemmed	Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.
title_sort	Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.
author	Santos, Luara Isabela dos
author_facet	Santos, Luara Isabela dos Galvão Filho, Bruno Faria, Paula Cristina de Junqueira, Caroline Dutra, Miriam Santos Teixeira, Santuza Maria Ribeiro Rodrigues, Maurício Martins Ritter, Gerd Bannard, Oliver Fearon, Douglas Thomas Antonelli, Lis Ribeiro do Valle Gazzinelli, Ricardo Tostes
author_role	author
author2	Galvão Filho, Bruno Faria, Paula Cristina de Junqueira, Caroline Dutra, Miriam Santos Teixeira, Santuza Maria Ribeiro Rodrigues, Maurício Martins Ritter, Gerd Bannard, Oliver Fearon, Douglas Thomas Antonelli, Lis Ribeiro do Valle Gazzinelli, Ricardo Tostes
author2_role	author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Santos, Luara Isabela dos Galvão Filho, Bruno Faria, Paula Cristina de Junqueira, Caroline Dutra, Miriam Santos Teixeira, Santuza Maria Ribeiro Rodrigues, Maurício Martins Ritter, Gerd Bannard, Oliver Fearon, Douglas Thomas Antonelli, Lis Ribeiro do Valle Gazzinelli, Ricardo Tostes
dc.subject.en.pt_BR.fl_str_mv	Antigens, Neoplasm/genetics Immunotherapy/methods Melanoma, Experimental/parasitology Recombinant Proteins/genetics CTAG1B protein, human
topic	Antigens, Neoplasm/genetics Immunotherapy/methods Melanoma, Experimental/parasitology Recombinant Proteins/genetics CTAG1B protein, human
description	2017-01-01
publishDate	2015
dc.date.issued.fl_str_mv	2015
dc.date.accessioned.fl_str_mv	2016-09-08T19:15:28Z
dc.date.available.fl_str_mv	2016-09-08T19:15:28Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	SANTOS, Luara Isabela dos et al. Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1. Cancer Immunol Immunother., vol. 64, n. 3, p. 311-323, 2015.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/15739
dc.identifier.issn.pt_BR.fl_str_mv	0340-7004
dc.identifier.doi.none.fl_str_mv	10.1007/s00262-014-1634-8
identifier_str_mv	SANTOS, Luara Isabela dos et al. Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1. Cancer Immunol Immunother., vol. 64, n. 3, p. 311-323, 2015. 0340-7004 10.1007/s00262-014-1634-8
url	https://www.arca.fiocruz.br/handle/icict/15739
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Springer-Verlagb
publisher.none.fl_str_mv	Springer-Verlagb
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/15739/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/15739/2/ve_Luara_Santos_etal_%20Blockade_CPqRR_2015.pdf https://www.arca.fiocruz.br/bitstream/icict/15739/3/ve_Luara_Santos_etal_%20Blockade_CPqRR_2015.pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.

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