Risk of Zika microcephaly correlates with features of maternal antibodies

Detalhes bibliográficos
Autor(a) principal: Robbiani, Davide F.
Data de Publicação: 2019
Outros Autores: Olsen, Priscilla C., Costa, Federico, Wang, Qiao, Oliveira, Thiago Yukio, Nery, Nivison, Aromolaran, Adeolu, Rosário, Mateus Santana do, Sacramento, Gielson Almeida do, Cruz, Jaqueline Silva, Cunha, Antonio Ricardo Khouri, Wunder Junior, Elsio Augusto, Mattos, Adriana, Freitas, Bruno de Paula, Sarno, Manoel, Archanjo, Gracinda, Daltro, Dina, Carvalho, Gustavo B. S., Pimentel, Kleber, Siqueira, Isadora Cristina de, Almeida, João R. M. de, Henriques, Daniele Freitas, Lima, Juliana A., Vasconcelos, Pedro F. C., Babajew, Dennis Schaefer, Azzopardi, Stephanie A., Bozzacco, Leonia, Gazumyan, Anna, Belfort, Rubens, Alcântara, Ana P., Carvalho, Gustavo, Moreira, Licia, Araujo, Katiaci, Reis, Mitermayer Galvão dos, Keesler, Rebekah I., Coffey, Lark L., Tisoncik-Go, Jennifer, Gale, Michael, Rajagopal, Lakshmi, Waldorf, Kristina M. Adams, Dudley, Dawn M., Simmons, Heather A., Mejia, Andres, O'Connor, David H., Steinbach, Rosemary J., Haese, Nicole, Smith, Jessica, Lewis, Anne, Colgin, Lois, Roberts, Victoria, Frias, Antonio, Kelleher, Meredith, Hirsch, Alec, Streblow, Daniel N., Rice, Charles M., MacDonald, Margaret R., Almeida, Antonio R. P. de, Van Rompay, Koen K. A., Ko, Albert Icksang, Nussenzweig, Michel C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36325
Resumo: National Institutes of Health grants 5R01AI121207, R01TW009504, and R25TW009338 to A.I. Ko; National Institutes of Health pilot awards U19AI111825 and UL1TR001866 to D.F. Robbiani; National Institutes of Health grants R01AI037526, UM1AI100663, U19AI111825, UL1TR001866, and P01AI138938 to M.C. Nussenzweig; National Institutes of Health grants R01AI124690 and U19AI057229 (Cooperative Center for Human Immunology pilot project); The Rockefeller University Development Office and anonymous donors (to C.M. Rice); Fundação de Amparo `a Pesquisa do Estado da Bahia grant PET0021/2016 (to M.G. Reis); National Institutes of Health grant R21AI129479-Supplement (to K.K.A. Van Rompay) and the National Institutes of Health Office of Research Infrastructure Programs/OD (P51OD011107 to the CNPRC); the United States Food and Drug Administration contract HHSF223201610542P (to L.L. Coffey); National Institutes of Health grants R01AI100989 and R01AI133976 (to L. Rajagopal and K.M. Adams Waldorf); and National Institutes of Health grants AI083019 and AI104002 (to M. Gale Jr.) and grant P51OD010425 to the WaNPRC (to K.M. Adams Waldorf, J. Tisoncik-Go, and M. Gale Jr.). Studies at WNPRC were supported by DHHS/PHS/National Institutes of Health grant R01Al116382-01A1 (to D.H. O’Connor), in part by the National Institutes of Health Office of Research Infrastructure Programs/OD (grant P51OD011106) awarded toWNPRC, at a facility constructed in part with support from Research Facilities Improvement Programgrants RR15459-01 and RR020141-01; and National Institutes of Health core and pilot grant P51 OD011092 and grants R21-HD091032 and R01-HD08633 (to ONPRC). P.F.C. Vasconcelos was supported by Conselho Nacional de Desenvolvimento Cientifico e Tecnológico (projects 303999/2016-0, 439971/20016-0, and 440405/2016-5) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Zika fast-track).
id CRUZ_53ca951d23d1842f1b75f6c169ece94e
oai_identifier_str oai:www.arca.fiocruz.br:icict/36325
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Robbiani, Davide F.Olsen, Priscilla C.Costa, FedericoWang, QiaoOliveira, Thiago YukioNery, NivisonAromolaran, AdeoluRosário, Mateus Santana doSacramento, Gielson Almeida doCruz, Jaqueline SilvaCunha, Antonio Ricardo KhouriWunder Junior, Elsio AugustoMattos, AdrianaFreitas, Bruno de PaulaSarno, ManoelArchanjo, GracindaDaltro, DinaCarvalho, Gustavo B. S.Pimentel, KleberSiqueira, Isadora Cristina deAlmeida, João R. M. deHenriques, Daniele FreitasLima, Juliana A.Vasconcelos, Pedro F. C.Babajew, Dennis SchaeferAzzopardi, Stephanie A.Bozzacco, LeoniaGazumyan, AnnaBelfort, RubensAlcântara, Ana P.Carvalho, GustavoMoreira, LiciaAraujo, KatiaciReis, Mitermayer Galvão dosKeesler, Rebekah I.Coffey, Lark L.Tisoncik-Go, JenniferGale, MichaelRajagopal, LakshmiWaldorf, Kristina M. AdamsDudley, Dawn M.Simmons, Heather A.Mejia, AndresO'Connor, David H.Steinbach, Rosemary J.Haese, NicoleSmith, JessicaLewis, AnneColgin, LoisRoberts, VictoriaFrias, AntonioKelleher, MeredithHirsch, AlecStreblow, Daniel N.Rice, Charles M.MacDonald, Margaret R.Almeida, Antonio R. P. deVan Rompay, Koen K. A.Ko, Albert IcksangNussenzweig, Michel C.2019-10-10T13:32:42Z2019-10-10T13:32:42Z2019ROBBIANI, Davide F. et al. Risk of Zika microcephaly correlates with features of maternal antibodies. Journal of Experimental Medicine, p. 1-14, Sept. 2019.0022-1007https://www.arca.fiocruz.br/handle/icict/3632510.1084/jem.20191061National Institutes of Health grants 5R01AI121207, R01TW009504, and R25TW009338 to A.I. Ko; National Institutes of Health pilot awards U19AI111825 and UL1TR001866 to D.F. Robbiani; National Institutes of Health grants R01AI037526, UM1AI100663, U19AI111825, UL1TR001866, and P01AI138938 to M.C. Nussenzweig; National Institutes of Health grants R01AI124690 and U19AI057229 (Cooperative Center for Human Immunology pilot project); The Rockefeller University Development Office and anonymous donors (to C.M. Rice); Fundação de Amparo `a Pesquisa do Estado da Bahia grant PET0021/2016 (to M.G. Reis); National Institutes of Health grant R21AI129479-Supplement (to K.K.A. Van Rompay) and the National Institutes of Health Office of Research Infrastructure Programs/OD (P51OD011107 to the CNPRC); the United States Food and Drug Administration contract HHSF223201610542P (to L.L. Coffey); National Institutes of Health grants R01AI100989 and R01AI133976 (to L. Rajagopal and K.M. Adams Waldorf); and National Institutes of Health grants AI083019 and AI104002 (to M. Gale Jr.) and grant P51OD010425 to the WaNPRC (to K.M. Adams Waldorf, J. Tisoncik-Go, and M. Gale Jr.). Studies at WNPRC were supported by DHHS/PHS/National Institutes of Health grant R01Al116382-01A1 (to D.H. O’Connor), in part by the National Institutes of Health Office of Research Infrastructure Programs/OD (grant P51OD011106) awarded toWNPRC, at a facility constructed in part with support from Research Facilities Improvement Programgrants RR15459-01 and RR020141-01; and National Institutes of Health core and pilot grant P51 OD011092 and grants R21-HD091032 and R01-HD08633 (to ONPRC). P.F.C. Vasconcelos was supported by Conselho Nacional de Desenvolvimento Cientifico e Tecnológico (projects 303999/2016-0, 439971/20016-0, and 440405/2016-5) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Zika fast-track).The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA / Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven / Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.Fudan University. School of Basic Medical Sciences. Shanghai Medical College. Key Laboratory of Medical Molecular Virology. Shanghai, China.The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven.Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven.Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil / Universidade Federal de São Paulo. São Paulo, SP, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.The Rockefeller University. Laboratory of Molecular Immunology. New York, NY.Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.Universidade Federal de São Paulo. São Paulo, SP, Brasil.Hospital Santo Amaro. Salvador, BA, Brasil.Hospital Santo Amaro. Salvador, BA, Brasil.Hospital Santo Amaro. Salvador, BA, Brasil.Hospital Aliança. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven / Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.University of California. California National Primate Research Center. Davis, Davis, CA, USA.University of California. School of Veterinary Medicine. Department of Pathology, Microbiology, and Immunology. Davis, Davis, CA, USA.Washington National Primate Research Center. Seattle, WA, USA / University of Washington. Center for Innate Immunity and Immune Disease. Seattle, WA, USA / University of Washington. Department of Immunology. Seattle, WA, USA.Washington National Primate Research Center. Seattle, WA / University of Washington. Center for Innate Immunity and Immune Disease. Seattle, WA, USA / University of Washington. Department of Immunology. Seattle, WA, USA / University of Washington. Department of Global Health. Seattle, WA, USA.University of Washington. Department of Global Health. Seattle, WA, USA / University of Washington. Department of Pediatrics. Seattle, WA, USA / Seattle Children’s Research Institute. Center for Global Infectious Disease Research. Seattle, WA, USA.Washington National Primate Research Center. Seattle, WA, USA / University of Washington. Center for Innate Immunity and Immune Disease. Seattle, WA, USA / University of Washington. Department of Global Health. Seattle, WA, USA / University of Washington. Department of Obstetrics and Gynecology. Seattle, WA, USA.University of Wisconsin-Madison. Department of Pathology and Laboratory Medicine. Madison, WI, USA.University of Wisconsin-Madison. Wisconsin National Primate Research Center. Madison, WI, USA.University of Wisconsin-Madison. Wisconsin National Primate Research Center. Madison, WI, USA.University of Wisconsin-Madison. Department of Pathology and Laboratory Medicine. Madison, WI, USA.Oregon National Primate Research Center. Division of Reproductive and Developmental Sciences. Beaverton, OR, USA.Oregon National Primate Research Center. Division of Pathobiology and Immunology. Beaverton, OR, USA / Oregon Health and Science University. Vaccine and Gene Therapy Institute. Portland, OR, USA.Oregon Health and Science University. Vaccine and Gene Therapy Institute. Portland, OR, USA.Oregon National Primate Research Center. Pathology Services Unit, Division of Comparative Medicine. Beaverton, OR, USA.Oregon National Primate Research Center. Division of Pathobiology and Immunology. Beaverton, OR, USA.Oregon National Primate Research Center. Division of Reproductive and Developmental Sciences. Beaverton, OR, USA.Oregon National Primate Research Center. Division of Reproductive and Developmental Sciences. Beaverton, OR, USA / Oregon Health and Science University. Department of Obstetrics and Gynecology. Portland, OR, USA.Oregon National Primate Research Center. Division of Reproductive and Developmental Sciences. Beaverton, OR, USA.Oregon National Primate Research Center. Division of Pathobiology and Immunology. Beaverton, OR, USA / Oregon Health and Science University. Vaccine and Gene Therapy Institute. Portland, OR, USA.Oregon National Primate Research Center. Division of Pathobiology and Immunology. Beaverton, OR, USA / Oregon Health and Science University. Vaccine and Gene Therapy Institute. Portland, OR, USA.Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.University of California. California National Primate Research Center. Davis, Davis, CA, USA / University of California. School of Veterinary Medicine. Department of Pathology, Microbiology, and Immunology. Davis, Davis, CA, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, USA.The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA / The Rockefeller University. Howard Hughes Medical Institute. New York, NY, USA.Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015-2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.engRockefeller University PressVirus zikaMicrocefaliaFatores de riscoGravidezAnomalias CongênitasZika virusMicrocephalyRisk factorsPregnancyCongenital AbnormalitiesRisk of Zika microcephaly correlates with features of maternal antibodiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36325/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRobbiani F D ...Risk.pdfRobbiani F D ...Risk.pdfapplication/pdf2296966https://www.arca.fiocruz.br/bitstream/icict/36325/2/Robbiani%20F%20D%20...Risk.pdf5e47aca9208f3f35c969fd82960279f4MD52TEXTRobbiani F D ...Risk.pdf.txtRobbiani F D ...Risk.pdf.txtExtracted texttext/plain74465https://www.arca.fiocruz.br/bitstream/icict/36325/3/Robbiani%20F%20D%20...Risk.pdf.txt0a4ba35f0ff6c749e66ceec423998ed2MD53icict/363252023-03-15 14:34:22.148oai:www.arca.fiocruz.br:icict/36325Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Risk of Zika microcephaly correlates with features of maternal antibodies
title Risk of Zika microcephaly correlates with features of maternal antibodies
spellingShingle Risk of Zika microcephaly correlates with features of maternal antibodies
Robbiani, Davide F.
Virus zika
Microcefalia
Fatores de risco
Gravidez
Anomalias Congênitas
Zika virus
Microcephaly
Risk factors
Pregnancy
Congenital Abnormalities
title_short Risk of Zika microcephaly correlates with features of maternal antibodies
title_full Risk of Zika microcephaly correlates with features of maternal antibodies
title_fullStr Risk of Zika microcephaly correlates with features of maternal antibodies
title_full_unstemmed Risk of Zika microcephaly correlates with features of maternal antibodies
title_sort Risk of Zika microcephaly correlates with features of maternal antibodies
author Robbiani, Davide F.
author_facet Robbiani, Davide F.
Olsen, Priscilla C.
Costa, Federico
Wang, Qiao
Oliveira, Thiago Yukio
Nery, Nivison
Aromolaran, Adeolu
Rosário, Mateus Santana do
Sacramento, Gielson Almeida do
Cruz, Jaqueline Silva
Cunha, Antonio Ricardo Khouri
Wunder Junior, Elsio Augusto
Mattos, Adriana
Freitas, Bruno de Paula
Sarno, Manoel
Archanjo, Gracinda
Daltro, Dina
Carvalho, Gustavo B. S.
Pimentel, Kleber
Siqueira, Isadora Cristina de
Almeida, João R. M. de
Henriques, Daniele Freitas
Lima, Juliana A.
Vasconcelos, Pedro F. C.
Babajew, Dennis Schaefer
Azzopardi, Stephanie A.
Bozzacco, Leonia
Gazumyan, Anna
Belfort, Rubens
Alcântara, Ana P.
Carvalho, Gustavo
Moreira, Licia
Araujo, Katiaci
Reis, Mitermayer Galvão dos
Keesler, Rebekah I.
Coffey, Lark L.
Tisoncik-Go, Jennifer
Gale, Michael
Rajagopal, Lakshmi
Waldorf, Kristina M. Adams
Dudley, Dawn M.
Simmons, Heather A.
Mejia, Andres
O'Connor, David H.
Steinbach, Rosemary J.
Haese, Nicole
Smith, Jessica
Lewis, Anne
Colgin, Lois
Roberts, Victoria
Frias, Antonio
Kelleher, Meredith
Hirsch, Alec
Streblow, Daniel N.
Rice, Charles M.
MacDonald, Margaret R.
Almeida, Antonio R. P. de
Van Rompay, Koen K. A.
Ko, Albert Icksang
Nussenzweig, Michel C.
author_role author
author2 Olsen, Priscilla C.
Costa, Federico
Wang, Qiao
Oliveira, Thiago Yukio
Nery, Nivison
Aromolaran, Adeolu
Rosário, Mateus Santana do
Sacramento, Gielson Almeida do
Cruz, Jaqueline Silva
Cunha, Antonio Ricardo Khouri
Wunder Junior, Elsio Augusto
Mattos, Adriana
Freitas, Bruno de Paula
Sarno, Manoel
Archanjo, Gracinda
Daltro, Dina
Carvalho, Gustavo B. S.
Pimentel, Kleber
Siqueira, Isadora Cristina de
Almeida, João R. M. de
Henriques, Daniele Freitas
Lima, Juliana A.
Vasconcelos, Pedro F. C.
Babajew, Dennis Schaefer
Azzopardi, Stephanie A.
Bozzacco, Leonia
Gazumyan, Anna
Belfort, Rubens
Alcântara, Ana P.
Carvalho, Gustavo
Moreira, Licia
Araujo, Katiaci
Reis, Mitermayer Galvão dos
Keesler, Rebekah I.
Coffey, Lark L.
Tisoncik-Go, Jennifer
Gale, Michael
Rajagopal, Lakshmi
Waldorf, Kristina M. Adams
Dudley, Dawn M.
Simmons, Heather A.
Mejia, Andres
O'Connor, David H.
Steinbach, Rosemary J.
Haese, Nicole
Smith, Jessica
Lewis, Anne
Colgin, Lois
Roberts, Victoria
Frias, Antonio
Kelleher, Meredith
Hirsch, Alec
Streblow, Daniel N.
Rice, Charles M.
MacDonald, Margaret R.
Almeida, Antonio R. P. de
Van Rompay, Koen K. A.
Ko, Albert Icksang
Nussenzweig, Michel C.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Robbiani, Davide F.
Olsen, Priscilla C.
Costa, Federico
Wang, Qiao
Oliveira, Thiago Yukio
Nery, Nivison
Aromolaran, Adeolu
Rosário, Mateus Santana do
Sacramento, Gielson Almeida do
Cruz, Jaqueline Silva
Cunha, Antonio Ricardo Khouri
Wunder Junior, Elsio Augusto
Mattos, Adriana
Freitas, Bruno de Paula
Sarno, Manoel
Archanjo, Gracinda
Daltro, Dina
Carvalho, Gustavo B. S.
Pimentel, Kleber
Siqueira, Isadora Cristina de
Almeida, João R. M. de
Henriques, Daniele Freitas
Lima, Juliana A.
Vasconcelos, Pedro F. C.
Babajew, Dennis Schaefer
Azzopardi, Stephanie A.
Bozzacco, Leonia
Gazumyan, Anna
Belfort, Rubens
Alcântara, Ana P.
Carvalho, Gustavo
Moreira, Licia
Araujo, Katiaci
Reis, Mitermayer Galvão dos
Keesler, Rebekah I.
Coffey, Lark L.
Tisoncik-Go, Jennifer
Gale, Michael
Rajagopal, Lakshmi
Waldorf, Kristina M. Adams
Dudley, Dawn M.
Simmons, Heather A.
Mejia, Andres
O'Connor, David H.
Steinbach, Rosemary J.
Haese, Nicole
Smith, Jessica
Lewis, Anne
Colgin, Lois
Roberts, Victoria
Frias, Antonio
Kelleher, Meredith
Hirsch, Alec
Streblow, Daniel N.
Rice, Charles M.
MacDonald, Margaret R.
Almeida, Antonio R. P. de
Van Rompay, Koen K. A.
Ko, Albert Icksang
Nussenzweig, Michel C.
dc.subject.other.pt_BR.fl_str_mv Virus zika
Microcefalia
Fatores de risco
Gravidez
Anomalias Congênitas
topic Virus zika
Microcefalia
Fatores de risco
Gravidez
Anomalias Congênitas
Zika virus
Microcephaly
Risk factors
Pregnancy
Congenital Abnormalities
dc.subject.en.pt_BR.fl_str_mv Zika virus
Microcephaly
Risk factors
Pregnancy
Congenital Abnormalities
description National Institutes of Health grants 5R01AI121207, R01TW009504, and R25TW009338 to A.I. Ko; National Institutes of Health pilot awards U19AI111825 and UL1TR001866 to D.F. Robbiani; National Institutes of Health grants R01AI037526, UM1AI100663, U19AI111825, UL1TR001866, and P01AI138938 to M.C. Nussenzweig; National Institutes of Health grants R01AI124690 and U19AI057229 (Cooperative Center for Human Immunology pilot project); The Rockefeller University Development Office and anonymous donors (to C.M. Rice); Fundação de Amparo `a Pesquisa do Estado da Bahia grant PET0021/2016 (to M.G. Reis); National Institutes of Health grant R21AI129479-Supplement (to K.K.A. Van Rompay) and the National Institutes of Health Office of Research Infrastructure Programs/OD (P51OD011107 to the CNPRC); the United States Food and Drug Administration contract HHSF223201610542P (to L.L. Coffey); National Institutes of Health grants R01AI100989 and R01AI133976 (to L. Rajagopal and K.M. Adams Waldorf); and National Institutes of Health grants AI083019 and AI104002 (to M. Gale Jr.) and grant P51OD010425 to the WaNPRC (to K.M. Adams Waldorf, J. Tisoncik-Go, and M. Gale Jr.). Studies at WNPRC were supported by DHHS/PHS/National Institutes of Health grant R01Al116382-01A1 (to D.H. O’Connor), in part by the National Institutes of Health Office of Research Infrastructure Programs/OD (grant P51OD011106) awarded toWNPRC, at a facility constructed in part with support from Research Facilities Improvement Programgrants RR15459-01 and RR020141-01; and National Institutes of Health core and pilot grant P51 OD011092 and grants R21-HD091032 and R01-HD08633 (to ONPRC). P.F.C. Vasconcelos was supported by Conselho Nacional de Desenvolvimento Cientifico e Tecnológico (projects 303999/2016-0, 439971/20016-0, and 440405/2016-5) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Zika fast-track).
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-10-10T13:32:42Z
dc.date.available.fl_str_mv 2019-10-10T13:32:42Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROBBIANI, Davide F. et al. Risk of Zika microcephaly correlates with features of maternal antibodies. Journal of Experimental Medicine, p. 1-14, Sept. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36325
dc.identifier.issn.pt_BR.fl_str_mv 0022-1007
dc.identifier.doi.none.fl_str_mv 10.1084/jem.20191061
identifier_str_mv ROBBIANI, Davide F. et al. Risk of Zika microcephaly correlates with features of maternal antibodies. Journal of Experimental Medicine, p. 1-14, Sept. 2019.
0022-1007
10.1084/jem.20191061
url https://www.arca.fiocruz.br/handle/icict/36325
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Rockefeller University Press
publisher.none.fl_str_mv Rockefeller University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/36325/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/36325/2/Robbiani%20F%20D%20...Risk.pdf
https://www.arca.fiocruz.br/bitstream/icict/36325/3/Robbiani%20F%20D%20...Risk.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
5e47aca9208f3f35c969fd82960279f4
0a4ba35f0ff6c749e66ceec423998ed2
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009269234073600