Risk of Zika microcephaly correlates with features of maternal antibodies

• Autor(a) principal: Robbiani, Davide F
• Data de Publicação: 2019
• Outros Autores: Olsen, Priscilla C, Costa, Federico, Wang, Qiao, Oliveira, Thiago Y, Nery Jr, Nivison, Aromolaran, Adeolu, Rosário, Mateus S. do, Sacramento, Gielson A, Cruz, Jaqueline S, Khouri, Ricardo, Wunder Jr, Elsio A, Mattos, Adriana, Freitas, Bruno de Paula, Sarno, Manoel, Archanjo, Gracinda, Daltro, Dina, Carvalho, Gustavo B. S, Pimentel, Kleber, Siqueira, Isadora C. de, Almeida, João Ricardo Maltez de, Henriques, Daniele Freitas, Lima, Juliana A, Vasconcelos, Pedro Fernando da Costa, Schaefer-Babajew, Dennis, Azzopardi, Stephanie A, Bozzacco, Leonia, Gazumyan, Anna, Belfort Jr, Rubens, Alcântara, Ana P, Carvalho, Gustavo, Moreira, Licia, Araujo, Katiaci, Reis, Mitermayer G, Keesler, Rebekah I, Coffey, Lark L, Tisoncik-Go, Jennifer, Gale Jr, Michael, Rajagopal, Laksmi, Waldorf, Kristina M. Adams, Dudley, Dawn M, Simmons, Heather A, Mejia, Andres, O'Connor, David H, Steinbach, Rosemary J, Haese, Nicole, Smith, Jessica, Lewis, Anne, Colgin, Lois, Roberts, Victoria, Frias, Antonio, Kelleher, Meredith, Hirsch, Alec, Streblow, Daniel N, Rice, Charles M, MacDonald, Margaret R, Almeida, Antonio R. P. de, Rompay, Koen K. A. Van, Ko, Albert I, Nussenzweig, Michel
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/3971
• topic: Virus zika / patogenicidade; Fatores de risco; Gravidez; Anomalias Congênitas; Microcefalia / genética

Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.