Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.

Alcantara, Luiz Carlos Júnior; Van Dooren, Sonia; Gonçalves, Marilda de Souza; Kashima, Simone G; Costa, Maria Cristina Ramos; Santos, Fred Luciano Neves; Bittencourt, Achilea Candida Lisboa; Dourado, Inês; Andrade Filho, Antonio de Souza; Covas, Dimas Tadeu; Vandamme, Anne-Mieke; Castro Filho, Bernardo Galvão

Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.

Detalhes bibliográficos
Autor(a) principal:	Alcantara, Luiz Carlos Júnior
Data de Publicação:	2003
Outros Autores:	Van Dooren, Sonia, Gonçalves, Marilda de Souza, Kashima, Simone G, Costa, Maria Cristina Ramos, Santos, Fred Luciano Neves, Bittencourt, Achilea Candida Lisboa, Dourado, Inês, Andrade Filho, Antonio de Souza, Covas, Dimas Tadeu, Vandamme, Anne-Mieke, Castro Filho, Bernardo Galvão
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/7994
Resumo:	Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Foundation for Scientific Development. Salvador, BA, Brasil

Metadados do item

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Alcantara, Luiz Carlos JúniorVan Dooren, SoniaGonçalves, Marilda de SouzaKashima, Simone GCosta, Maria Cristina RamosSantos, Fred Luciano NevesBittencourt, Achilea Candida LisboaDourado, InêsAndrade Filho, Antonio de SouzaCovas, Dimas TadeuVandamme, Anne-MiekeCastro Filho, Bernardo Galvão2014-07-17T19:33:23Z2014-07-17T19:33:23Z2003ALCANTARA JUNIOR, L. C. et al. Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus. Journal of Acquired Immune Deficiency Syndromes, v. 33, n. 4, p. 536-542, 2003.1525-4135https://www.arca.fiocruz.br/handle/icict/7994engMary Ann Liebert, IncGlobin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Foundation for Scientific Development. Salvador, BA, BrasilRega Institute. Katholieke Universiteit Leuven. BelgiumFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilBrazil Blood Scientific Development. Salvador, BA, BrasilBrazil Blood Scientific Development. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Foundation for Scientific Development. Salvador, BA, BrasilFederal University of Bahia. Salvador, BA, BrasilFederal University of Bahia. Salvador, BA, BrasilBahia School of Medicine and Public Health. Foundation for Scientific Development. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, BrasilBrazil Blood Scientific Development. Salvador, BA, BrasilRega Institute. Katholieke Universiteit Leuven. BelgiumFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Foundation for Scientific Development. Salvador, BA, BrasilThe city of Salvador, Bahia, Brazil, has sociodemographic characteristics similar to some African cities. Up to now, it has had the highest prevalence of human T-cell lymphotropic virus type I (HTLV-I) infection (1.74%) in the country. To investigate which strains of HTLV-I are circulating in Salvador, we studied isolates from 82 patients infected with HTLV-I: 19 from the general population, 21 from pregnant women, 16 from intravenous drug users, and 26 from patients and their family attending a neurologic clinic. Phylogenetic analysis from part of the LTR fragments showed that most of these isolates belonged to the Transcontinental subgroup of the Cosmopolitan subtype (HTLV-Ia). Only one sample from a pregnant woman was closely related to the Japanese subgroup, suggesting recent introduction of a Japanese HTLV-I lineage into Salvador. A-Globin haplotypes were examined in 34 infected individuals and found to be atypical, confirming the racial heterogeneity of this population. A total of 20 chromosomes were characterized as Central African Republic (CAR) haplotype (29.4%), 31 (45.6%) were characterized as Benin (BEN) haplotype, and 17 (25%) were characterized as Senegal (SEN) haplotype. Five patients’ genotypes (14.7%) were CAR/CAR; 10 (29,4%), BEN/BEN; 9 (26.5%), CAR/BEN; 2 (5.9%), BEN/SEN; and 7 (20.6%), SEN/SEN. One patient’s genotype (2.9%) was CAR/SEN. The A-globin haplotype distribution in Salvador is unusual compared with other Brazilian states. Our data support the hypothesis of multiple post-Columbian introductions of African HTLV-Ia strains in Salvador, Bahia, BrazilHTLV-1LTRB globin haplotypesBantuSalvador-BrazilSouthern AfricaGlobinas/genéticaInfecções por HTLV-I/virologiaHaplotiposVírus 1 Linfotrópico T Humano/classificaçãoBrasilHumanosFilogeniaSequências Repetidas Terminaisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAlcantara LC Globin haplotypes of human T-cell....pdfAlcantara LC Globin haplotypes of human T-cell....pdfapplication/pdf365766https://www.arca.fiocruz.br/bitstream/icict/7994/1/Alcantara%20LC%20Globin%20haplotypes%20of%20human%20T-cell....pdf185a88da3dbde9d7630368055aeb4c17MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7994/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTAlcantara LC Globin haplotypes of human T-cell....pdf.txtAlcantara LC Globin haplotypes of human T-cell....pdf.txtExtracted texttext/plain30408https://www.arca.fiocruz.br/bitstream/icict/7994/3/Alcantara%20LC%20Globin%20haplotypes%20of%20human%20T-cell....pdf.txtac8c75f33b3b362145183893f5503d40MD53icict/79942023-03-15 14:33:05.971oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.
title	Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.
spellingShingle	Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus. Alcantara, Luiz Carlos Júnior HTLV-1 LTR B globin haplotypes Bantu Salvador-Brazil Southern Africa Globinas/genética Infecções por HTLV-I/virologia Haplotipos Vírus 1 Linfotrópico T Humano/classificação Brasil Humanos Filogenia Sequências Repetidas Terminais
title_short	Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.
title_full	Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.
title_fullStr	Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.
title_full_unstemmed	Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.
title_sort	Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.
author	Alcantara, Luiz Carlos Júnior
author_facet	Alcantara, Luiz Carlos Júnior Van Dooren, Sonia Gonçalves, Marilda de Souza Kashima, Simone G Costa, Maria Cristina Ramos Santos, Fred Luciano Neves Bittencourt, Achilea Candida Lisboa Dourado, Inês Andrade Filho, Antonio de Souza Covas, Dimas Tadeu Vandamme, Anne-Mieke Castro Filho, Bernardo Galvão
author_role	author
author2	Van Dooren, Sonia Gonçalves, Marilda de Souza Kashima, Simone G Costa, Maria Cristina Ramos Santos, Fred Luciano Neves Bittencourt, Achilea Candida Lisboa Dourado, Inês Andrade Filho, Antonio de Souza Covas, Dimas Tadeu Vandamme, Anne-Mieke Castro Filho, Bernardo Galvão
author2_role	author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Alcantara, Luiz Carlos Júnior Van Dooren, Sonia Gonçalves, Marilda de Souza Kashima, Simone G Costa, Maria Cristina Ramos Santos, Fred Luciano Neves Bittencourt, Achilea Candida Lisboa Dourado, Inês Andrade Filho, Antonio de Souza Covas, Dimas Tadeu Vandamme, Anne-Mieke Castro Filho, Bernardo Galvão
dc.subject.en.pt_BR.fl_str_mv	HTLV-1 LTR B globin haplotypes Bantu Salvador-Brazil Southern Africa
topic	HTLV-1 LTR B globin haplotypes Bantu Salvador-Brazil Southern Africa Globinas/genética Infecções por HTLV-I/virologia Haplotipos Vírus 1 Linfotrópico T Humano/classificação Brasil Humanos Filogenia Sequências Repetidas Terminais
dc.subject.decs.pt_BR.fl_str_mv	Globinas/genética Infecções por HTLV-I/virologia Haplotipos Vírus 1 Linfotrópico T Humano/classificação Brasil Humanos Filogenia Sequências Repetidas Terminais
description	Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Foundation for Scientific Development. Salvador, BA, Brasil
publishDate	2003
dc.date.issued.fl_str_mv	2003
dc.date.accessioned.fl_str_mv	2014-07-17T19:33:23Z
dc.date.available.fl_str_mv	2014-07-17T19:33:23Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ALCANTARA JUNIOR, L. C. et al. Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus. Journal of Acquired Immune Deficiency Syndromes, v. 33, n. 4, p. 536-542, 2003.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/7994
dc.identifier.issn.none.fl_str_mv	1525-4135
identifier_str_mv	ALCANTARA JUNIOR, L. C. et al. Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus. Journal of Acquired Immune Deficiency Syndromes, v. 33, n. 4, p. 536-542, 2003. 1525-4135
url	https://www.arca.fiocruz.br/handle/icict/7994
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Mary Ann Liebert, Inc
publisher.none.fl_str_mv	Mary Ann Liebert, Inc
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/7994/1/Alcantara%20LC%20Globin%20haplotypes%20of%20human%20T-cell....pdf https://www.arca.fiocruz.br/bitstream/icict/7994/2/license.txt https://www.arca.fiocruz.br/bitstream/icict/7994/3/Alcantara%20LC%20Globin%20haplotypes%20of%20human%20T-cell....pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.

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