Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: a multinational cohort study

Bibliographic Details
Main Author: Pereira, Mariana Araújo
Publication Date: 2022
Other Authors: Sheikh, Virginia, Sereti, Irini, Duarte, Beatriz Barreto, Arriaga, María B., Tibúrcio, Rafael, Vinhaes, Caian L., Almeida, Manuella Pinto de, Wang, Jing, Rupert, Adam, Roby, Gregg, Shaffer, Douglas, Ananworanich, Jintanat, Phanuphak, Nittaya, Sawe, Fred, Andrade, Bruno B.
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/56010
Summary: Pesquisa Interna do Instituto Nacional de Alergia e Doenças Infecciosas/Institutos Nacionais de Saúde (NIAID/NIH). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
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spelling Pereira, Mariana AraújoSheikh, VirginiaSereti, IriniDuarte, Beatriz BarretoArriaga, María B.Tibúrcio, RafaelVinhaes, Caian L.Almeida, Manuella Pinto deWang, JingRupert, AdamRoby, GreggShaffer, DouglasAnanworanich, JintanatPhanuphak, NittayaSawe, FredAndrade, Bruno B.2022-12-16T14:02:00Z2022-12-16T14:02:00Z2022PEREIRA, Mariana Araújo et al. Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: A multinational cohort study. eBioMedicine, v. 85, p. 1-12, 2022.2352-3964https://www.arca.fiocruz.br/handle/icict/5601010.1016/j.ebiom.2022.104309Pesquisa Interna do Instituto Nacional de Alergia e Doenças Infecciosas/Institutos Nacionais de Saúde (NIAID/NIH). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Patologia Humana e Experimental. Salvador, BA, Brasil.National Institutes of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, USA.National Institutes of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Clínica Médica. Rio de Janeiro, RJ, Brasil / Universidade Salvador. Curso de Medicina. Salvador. BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Patologia Humana e Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Patologia Humana e Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Fundação Bahiana para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Salvador. Curso de Medicina. Salvador. BA, Brasil.Clinical Monitoring Research Program Directorate. Frederick National Laboratory for Cancer Research. Frederick, MD, USA.National Institutes of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, USA.National Institutes of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, USA.Kenya Medical Research Institute. Henry Jackson Foundation Medical Research International. Bethesda, MD, USA / Walter Reed Army Institute of Research/US Army Medical Research Directorate-Africa. Nairobi, Kenya.Southeast Asia Research Collaboration with Hawaii. Henry M. Jackson Foundation for the Advancement of Military Medicine. United States Military HIV Research Program. Bethesda, MD, USA.SEARCH. Institute of HIV Research and Innovation. Bangkok, Thailand.Kenya Medical Research Institute. Henry Jackson Foundation Medical Research International. Bethesda, MD, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Patologia Humana e Experimental. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Clínica Médica. Rio de Janeiro, RJ, Brasil / Universidade Salvador. Curso de Medicina. Salvador. BA, Brasil.Background: After initiating antiretroviral therapy (ART), approximately 25% of people with HIV (PWH) may develop Immune Reconstitution Inflammatory Syndrome (IRIS), which is associated with increased morbidity and mortality. Several reports have demonstrated that low haemoglobin (Hb) levels are a risk factor for IRIS. To what extent the severity of anaemia contributes to the risk of IRIS and/or death is still insufficiently explored. Methods: We investigated both the presence and severity of anaemia in PWH in a multinational cohort of ART-naïve patients. A large panel of plasma biomarkers was measured pre-ART and patients were followed up for 6 months. IRIS or deaths during this period were considered as outcomes. We performed multidimensional analyses, logistic regression, and survival curves to delineate associations. Findings: Patients with severe anaemia (SA) presented a distinct systemic inflammatory profile, characterized by higher TNF, IL-6, and IL-27 levels. SA was independently associated with IRIS, with a higher risk of both early IRIS onset and death. Among IRIS patients, those with SA had a higher risk of mycobacterial IRIS. Interpretation: PWH with SA display a more pronounced inflammatory profile, with an elevated risk of developing IRIS earlier and a statistically significant higher risk of death.engElsevierTuberculoseInflamação sistêmicaIRISHIVTuberculosisSystemic inflammationIRISDeathHIVTuberculoseIrisMorteHIVAssociation between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: a multinational cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAraujo-Pereira, M. Association between severe anaemia and....pdfAraujo-Pereira, M. 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dc.title.en_US.fl_str_mv Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: a multinational cohort study
title Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: a multinational cohort study
spellingShingle Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: a multinational cohort study
Pereira, Mariana Araújo
Tuberculose
Inflamação sistêmica
IRIS
HIV
Tuberculosis
Systemic inflammation
IRIS
Death
HIV
Tuberculose
Iris
Morte
HIV
title_short Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: a multinational cohort study
title_full Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: a multinational cohort study
title_fullStr Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: a multinational cohort study
title_full_unstemmed Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: a multinational cohort study
title_sort Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: a multinational cohort study
author Pereira, Mariana Araújo
author_facet Pereira, Mariana Araújo
Sheikh, Virginia
Sereti, Irini
Duarte, Beatriz Barreto
Arriaga, María B.
Tibúrcio, Rafael
Vinhaes, Caian L.
Almeida, Manuella Pinto de
Wang, Jing
Rupert, Adam
Roby, Gregg
Shaffer, Douglas
Ananworanich, Jintanat
Phanuphak, Nittaya
Sawe, Fred
Andrade, Bruno B.
author_role author
author2 Sheikh, Virginia
Sereti, Irini
Duarte, Beatriz Barreto
Arriaga, María B.
Tibúrcio, Rafael
Vinhaes, Caian L.
Almeida, Manuella Pinto de
Wang, Jing
Rupert, Adam
Roby, Gregg
Shaffer, Douglas
Ananworanich, Jintanat
Phanuphak, Nittaya
Sawe, Fred
Andrade, Bruno B.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Mariana Araújo
Sheikh, Virginia
Sereti, Irini
Duarte, Beatriz Barreto
Arriaga, María B.
Tibúrcio, Rafael
Vinhaes, Caian L.
Almeida, Manuella Pinto de
Wang, Jing
Rupert, Adam
Roby, Gregg
Shaffer, Douglas
Ananworanich, Jintanat
Phanuphak, Nittaya
Sawe, Fred
Andrade, Bruno B.
dc.subject.other.en_US.fl_str_mv Tuberculose
Inflamação sistêmica
IRIS
HIV
topic Tuberculose
Inflamação sistêmica
IRIS
HIV
Tuberculosis
Systemic inflammation
IRIS
Death
HIV
Tuberculose
Iris
Morte
HIV
dc.subject.en.en_US.fl_str_mv Tuberculosis
Systemic inflammation
IRIS
Death
HIV
dc.subject.decs.en_US.fl_str_mv Tuberculose
Iris
Morte
HIV
description Pesquisa Interna do Instituto Nacional de Alergia e Doenças Infecciosas/Institutos Nacionais de Saúde (NIAID/NIH). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-12-16T14:02:00Z
dc.date.available.fl_str_mv 2022-12-16T14:02:00Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PEREIRA, Mariana Araújo et al. Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: A multinational cohort study. eBioMedicine, v. 85, p. 1-12, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56010
dc.identifier.issn.en_US.fl_str_mv 2352-3964
dc.identifier.doi.none.fl_str_mv 10.1016/j.ebiom.2022.104309
identifier_str_mv PEREIRA, Mariana Araújo et al. Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: A multinational cohort study. eBioMedicine, v. 85, p. 1-12, 2022.
2352-3964
10.1016/j.ebiom.2022.104309
url https://www.arca.fiocruz.br/handle/icict/56010
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56010/2/Araujo-Pereira%2c%20M.%20Association%20between%20severe%20anaemia%20and....pdf
https://www.arca.fiocruz.br/bitstream/icict/56010/1/license.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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