Placental histopatology and clinical presentation of severe congenital Zika Syndrome in a human immunodeficiency virus-exposed uninfected infant
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.3389/fimmu.2017.01704 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23924 |
Resumo: | Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil. |
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Rabelo, KissilaFernandes, Regina Célia de Souza CamposSouza, Luiz JoséSouza, Thais Louvain deSantos, Flávia Barreto dosNunes, Priscila Conrado GuerraAzeredo, Elzinandes Leal deSalomão, Natália GedeãoTrindade, Gisela FreitasOliveira, Carlos A. Basílio deCarvalho, Jorge José deMedina-Acosta, EnriquePaes, Marciano Viana2018-01-16T13:59:35Z2018-01-16T13:59:35Z2017RABELO, Kissila; et al. Placental Histopathology and Clinical Presentation of Severe Congenital Zika Syndrome in a Human Immunodeficiency Virus-Exposed Uninfected Infant. Frontiers in Immunology, v.8:1704, 8p, Dec. 2017.1664-3224https://www.arca.fiocruz.br/handle/icict/2392410.3389/fimmu.2017.01704engFrontiers MediaZika virusPlacentaHistopatologiaMicrocefaliaSíndrome congénita de Zikavírus da imunodeficiência humanaCriançasZika virusplacentacongenital Zika syndromehistopathologymicrocephalyhuman immunodeficiency virusinfantPlacental histopatology and clinical presentation of severe congenital Zika Syndrome in a human immunodeficiency virus-exposed uninfected infantinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil / Universidade Estadual do Norte Fluminense. Laboratório de Biotecnologia. Campos dos Goytacazes, RJ, Brasil.Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil.Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil / Universidade Estadual do Norte Fluminense. Laboratório de Biotecnologia. Campos dos Goytacazes, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Biomanguinhos. Laboratório de Tecnologia Virológica. Rio de Janeiro, RJ. Brasil.Universidade Federal do Estado do Rio de Janeiro. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Universidade Estadual do Norte Fluminense. Laboratório de Biotecnologia. Campos dos Goytacazes, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.In the large Zika virus (ZIKV) epidemic that occurred in Brazil in 2015, the intrauterine fetal exposure to ZIKV was associated with a significant risk of developing microcephaly and neurological disorders in the infected infants. ZIKV-associated disease has since been reported in 24 countries in the Americas. At present, definitive evidence is lacking regarding the intrauterine co-exposure to ZIKV and other viral infections and whether the coinfection impacts the risk of acquiring either infection or disease severity. Here, we provide evidence of intrauterine exposure to both ZIKV and human immunodeficiency virus (HIV) infections, causing congenital Zika syndrome in an HIV-exposed uninfected infant. Clinical, imaging and laboratory examinations of the pregnant woman and the newborn were performed. Histopathology, ZIKV/HIV-specific immunoassays, and ultrastructural evaluation of the placenta were performed. The Zika-asymptomatic, HIV-positive pregnant woman underwent ultrasounds revealing fetal cerebral ventriculomegaly, microcephaly, and brain atrophy. Her baby girl was born small for gestational age and with the neurological sequelae of congenital Zika syndrome. The evaluation of the abnormally large term placenta revealed severe damage to the maternal decidua and chorionic villi, cells positive for ZIKV-specific antigens but not for HIV antigens, and intracellular membranous clusters of virus-like particles approximately 25 nm in diameter. The rapid progression and severity of the congenital Zika syndrome may be related to the uncontrolled HIV disease in the mother. The poor inflammatory response observed in the placenta may have reduced the inherent risk of mother-to-child transmission of HIV.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23924/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALflavia_santos_etal_IOC_2017.pdfflavia_santos_etal_IOC_2017.pdfapplication/pdf3809350https://www.arca.fiocruz.br/bitstream/icict/23924/2/flavia_santos_etal_IOC_2017.pdf4d9ef1ac3e72042bfdc5b1a8428c23d5MD52TEXTflavia_santos_etal_IOC_2017.pdf.txtflavia_santos_etal_IOC_2017.pdf.txtExtracted texttext/plain38875https://www.arca.fiocruz.br/bitstream/icict/23924/3/flavia_santos_etal_IOC_2017.pdf.txt746af51cd353a1cd78e0e88f28673545MD53icict/239242023-09-05 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| dc.title.pt_BR.fl_str_mv |
Placental histopatology and clinical presentation of severe congenital Zika Syndrome in a human immunodeficiency virus-exposed uninfected infant |
| title |
Placental histopatology and clinical presentation of severe congenital Zika Syndrome in a human immunodeficiency virus-exposed uninfected infant |
| spellingShingle |
Placental histopatology and clinical presentation of severe congenital Zika Syndrome in a human immunodeficiency virus-exposed uninfected infant Rabelo, Kissila Zika virus Placenta Histopatologia Microcefalia Síndrome congénita de Zika vírus da imunodeficiência humana Crianças Zika virus placenta congenital Zika syndrome histopathology microcephaly human immunodeficiency virus infant |
| title_short |
Placental histopatology and clinical presentation of severe congenital Zika Syndrome in a human immunodeficiency virus-exposed uninfected infant |
| title_full |
Placental histopatology and clinical presentation of severe congenital Zika Syndrome in a human immunodeficiency virus-exposed uninfected infant |
| title_fullStr |
Placental histopatology and clinical presentation of severe congenital Zika Syndrome in a human immunodeficiency virus-exposed uninfected infant |
| title_full_unstemmed |
Placental histopatology and clinical presentation of severe congenital Zika Syndrome in a human immunodeficiency virus-exposed uninfected infant |
| title_sort |
Placental histopatology and clinical presentation of severe congenital Zika Syndrome in a human immunodeficiency virus-exposed uninfected infant |
| author |
Rabelo, Kissila |
| author_facet |
Rabelo, Kissila Fernandes, Regina Célia de Souza Campos Souza, Luiz José Souza, Thais Louvain de Santos, Flávia Barreto dos Nunes, Priscila Conrado Guerra Azeredo, Elzinandes Leal de Salomão, Natália Gedeão Trindade, Gisela Freitas Oliveira, Carlos A. Basílio de Carvalho, Jorge José de Medina-Acosta, Enrique Paes, Marciano Viana |
| author_role |
author |
| author2 |
Fernandes, Regina Célia de Souza Campos Souza, Luiz José Souza, Thais Louvain de Santos, Flávia Barreto dos Nunes, Priscila Conrado Guerra Azeredo, Elzinandes Leal de Salomão, Natália Gedeão Trindade, Gisela Freitas Oliveira, Carlos A. Basílio de Carvalho, Jorge José de Medina-Acosta, Enrique Paes, Marciano Viana |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rabelo, Kissila Fernandes, Regina Célia de Souza Campos Souza, Luiz José Souza, Thais Louvain de Santos, Flávia Barreto dos Nunes, Priscila Conrado Guerra Azeredo, Elzinandes Leal de Salomão, Natália Gedeão Trindade, Gisela Freitas Oliveira, Carlos A. Basílio de Carvalho, Jorge José de Medina-Acosta, Enrique Paes, Marciano Viana |
| dc.subject.other.pt_BR.fl_str_mv |
Zika virus Placenta Histopatologia Microcefalia Síndrome congénita de Zika vírus da imunodeficiência humana Crianças |
| topic |
Zika virus Placenta Histopatologia Microcefalia Síndrome congénita de Zika vírus da imunodeficiência humana Crianças Zika virus placenta congenital Zika syndrome histopathology microcephaly human immunodeficiency virus infant |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus placenta congenital Zika syndrome histopathology microcephaly human immunodeficiency virus infant |
| description |
Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil. |
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2017 |
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2017 |
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2018-01-16T13:59:35Z |
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2018-01-16T13:59:35Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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RABELO, Kissila; et al. Placental Histopathology and Clinical Presentation of Severe Congenital Zika Syndrome in a Human Immunodeficiency Virus-Exposed Uninfected Infant. Frontiers in Immunology, v.8:1704, 8p, Dec. 2017. |
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https://www.arca.fiocruz.br/handle/icict/23924 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2017.01704 |
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RABELO, Kissila; et al. Placental Histopathology and Clinical Presentation of Severe Congenital Zika Syndrome in a Human Immunodeficiency Virus-Exposed Uninfected Infant. Frontiers in Immunology, v.8:1704, 8p, Dec. 2017. 1664-3224 10.3389/fimmu.2017.01704 |
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Frontiers Media |
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Frontiers Media |
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